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Department of Biochemistry

 

PAPERS

BOOKS

PATENT APPLICATIONS

Refereed papers

  1. de Prat-Gay, G., Gaston, K., and Cicero, D. O. (2008) The papillomavirus E2 DNA binding domain: A unique fold with unique properties for multiple regulatory functions in the viral life cycle. Frontiers in Bioscience, In press.

  2. Sánchez IE, Dellarole M, Gaston K, and de Prat Gay G. (2008) Comprehensive comparison of the interaction of the E2 master regulator with its cognate target DNA sites in 73 human papillomavirus types by sequence statistics. Nucleic Acids Research, 36: 756-69.

  3. Brown C, Kowalczyk AM, Taylor ER, Morgan IM, Gaston K. (2008) p53 represses human papillomavirus type 16 DNA replication via the viral E2 protein. Virology Journal, 5: 5. LINK TO PDF FILE

  4. Green, K.L., Brown, C., Roeder, G., Southgate, T., and Gaston K. (2007) A cancer cell-specific inducer of apoptosis. Human Gene Therapy, 18: 547-61. LINK TO PDF FILE

  5. Bacon, A., Kerr, N.C.H. Holmes, F. E. Gaston, K., and Wynick, D. (2007) Characterization of an enhancer region of the Galanin gene that directs expression to the dorsal root ganglion and confers responsiveness to axotomy. Journal of Neuroscience, 27: 6573-6580. LINK TO PDF FILE

  6. Parish, J., Kowalczyk, A., Chen, H.-T., Sessions, R., Buckle, M., and Gaston, K. (2006) The E2 proteins from high- and low-risk HPV types differ in their ability to bind p53 and induce apoptotic cell death. Journal of Virology. 80: 4580-4590. LINK TO PDF FILE

  7. Hooley, E., Fairweather, V., Clarke, A. R., Gaston, K., and Brady R. L. (2006) The recognition of local DNA conformation by the Human Papillomavirus type 6 E2 protein. Nucleic acids Research. 34: 3897-3908. LINK TO PDF FILE

  8. Soufi, A., Smith, C., Clarke, A. R., Gaston, K., and Jayaraman, P-S. (2006) Oligomerisation of the homeodomain protein PRH is mediated by a novel proline-rich dimerisation interface. Journal of Molecular Biology. 358: 943-962. LINK TO PDF FILE

  9. Green, K. L. Southgate, T., Mulryan, K., Fairbairn L. J. Stern P. L., and Gaston, K. (2006) Diffusible VP22-E2 protein kills bystander cells and offers a route for cervical cancer gene therapy. Human Gene Therapy. 17:147-157. LINK TO PDF FILE

  10. Soufi, A., Gaston, K., and Jayaraman, P-S. (2006) Purification and characterisation of the PRH homeodomain: the N-terminal domain of PRH inhibits the homeodomain-DNA interaction. International Journal of Biological Macromolecules. 39: 45-50.

  11. Green K. L., and Gaston, K. (2006) Development of a topical protein therapeutic for HPV and associated cancers. Biodrugs. 20: 209-218. LINK TO PDF FILE

  12. Roeder, G., Parish, J., Stern, P.L., and Gaston, K. (2004) Herpes Simplex Virus VP22-human papillomavirus E2 fusion proteins produced in mammalian or bacterial cells enter mammalian cells and induce apoptotic cell death. Biotechnology and Applied Biochemistry, 40: 157-165. LINK TO PDF FILE

  13. Dell, G., Wilkinson, K.W. Tranter, R., Parish, J., Brady, R.L., and Gaston, K. (2003) Comparison of the structure and DNA binding properties of the E2 proteins from an oncogenic and a non-oncogenic human papillomavirus. Journal of Molecular Biology, 334: 979-991. LINK TO PDF FILE

  14. Davidson, E. J., Sehr, P., Faulkner, R. L., Parish, J. L., Gaston, K., Moore, R. A., Pawlita, M., Kitchener, H. C., and Stern P. L. (2003) Human papillomavirus type 16 E2- and L1-specific serological and T-cell responses in women with vulval intraepithelial neoplasia. Journal of General Virology,  84: 2089-2097. LINK TO PDF FILE

  15. Bess, K. L., Swingler, T. E., Rivett, A. J., Gaston, K., and Jayaraman, P. -S. (2003). The transcriptional repressor protein PRH interacts with the proteasome. Biochemical Journal, 374: 667–675. LINK TO PDF FILE

  16. Gaston, K., and Jayaraman, P. -S. (2003). Transcriptional Repression in Eukaryotes: Repressors and Repression Mechanisms. Cellular and Molecular Life Sciences, 60: 721-741. LINK TO PDF FILE

  17. Butcher, A. J., Gaston, K., and Jayaraman, P. -S. (2003). Purification of the proline-rich homeodomain protein. Journal of Chromatography, 786: 3-6. LINK TO PDF FILE

  18. Rees, L. E. N., Wood, N. A. P., Gillespie, K. M., Lai, K. N., Gaston, K., and Mathieson, P. W. (2002). The interleukin-10 (IL-10) -1082 G/A polymorphism: Allele frequency in different populations and functional significance. Cellular and Molecular Life Sciences, 59: 1-10. LINK TO PDF FILE

  19. Dell, G., and Gaston, K. (2001). Human papillomaviruses and their role in cervical cancer. Cellular and Molecular Life Sciences, 58: 1923-1942. LINK TO PDF FILE

  20. Webster, K., Taylor, A., and Gaston, K. (2001). Estrogen and progesterone increase the levels of apoptosis induced by the HPV 16 E2 and E7 proteins. Journal of General Virology, 82: 149-158. LINK TO PDF FILE

  21. Davidson, E J., Brown, M. D., Burt, D. J., Parish, J. L., Gaston, K., Kitchener, H. C., Stacey, S. N., and Stern, P. L. (2001) Human T cell responses to HPV 16 E2 generated with monocyte-derived dendritic cells. International Journal of Cancer,  94: 807-812. LINK TO PDF FILE

  22. Webster, K., Parish, J., Pandya, M., Stern P. L., Clarke. A. R., and Gaston, K. (2000). The HPV 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway. Journal of Biological Chemistry, 275: 87-94. LINK TO PDF FILE

  23. Vernon E. G. and Gaston, K. (2000). Myc and YY1 mediate activation of the Surf-1 promoter in response to serum growth factors. Biochimica et Biophysica Acta, 1492: 172-179. LINK TO PDF FILE

  24. Lewis, H., and Gaston, K. (1999). Magnesium ions enhance the transfer of human papillomavirus E2 protein from non-specific to specific binding sites. Journal of Molecular Biology, 294: 885-896. LINK TO PDF FILE

  25. Lewis, H., Webster, K., Sanchez-Perez, A. -M., and Gaston, K. (1999). Cellular transcription factors regulate human papillomavirus type 16 gene expression by binding to a subset of the DNA sequences recognised by the viral E2 protein. Journal of General Virology, 80: 2087-2096. LINK TO PDF FILE

  26. Sanchez-Perez, A, -M., Soriano, S., Clarke, A. R., and Gaston, K. (1997). Disruption of the HPV 16 E2 gene protects cervical carcinoma cells from E2F-induced apoptosis. Journal of General Virology, 78: 3009-3018. LINK TO PDF FILE

  27. Cole, E. G., and Gaston, K. (1997). A functional YY1 binding site is necessary and sufficient to activate Surf-1 promoter activity in response to serum growth factors. Nucleic Acids Research, 25: 3705-3711. LINK TO PDF FILE

  28. Thain, A., Webster, K., Emery, D., Clarke, A. R., and Gaston, K. (1997). DNA binding and bending by the human papillomavirus type 16 E2 protein: recognition of an extended binding site. Journal of Biological Chemistry, 272: 8236-8242. LINK TO PDF FILE

  29. Thain, A., Jenkins, O., Clarke, A. R., and Gaston, K. (1996). CpG methylation directly inhibits binding of the HPV 16 E2 protein to specific DNA sequences.  Journal of Virology, 70: 7233-7235. LINK TO PDF FILE

  30. Thain, A., Gaston, K., Jenkins, O., and Clarke, A. R. (1996). A method for the separation of GST fusion proteins from co-purifying GroEL. Trends in Genetics, 12: 209-210.

  31. Gaston, K., and Fried, M. (1995). CpG methylation has differential effects on the binding of YY1 and ETS proteins to the bi-directional promoter of the Surf-1 and Surf-2 genes. Nucleic Acids Research,  23: 901-909. LINK TO PDF FILE

  32. Gaston, K., and Fried, M. (1995). CpG methylation and the binding of YY1 and ETS proteins to the Surf-1/Surf-2 bi-directional promoter. Gene, 157: 257-259.

  33. Gaston, K., and Fried, M. (1994). YY1 is involved in the regulation of the bi-directional promoter of the Surf-1 and Surf-2 genes. FEBS Letters, 347: 289-294.

  34. Lennard, A., Gaston, K., and Fried, M. (1994). Conservation of the Surf-1 and Surf-2 genes and their essential bi-directional promoter elements. DNA and Cell Biology, 13: 1117-1126.

  35. Gaston, K.,Bell, A., Busby, S., and Fried, M. (1992). A comparison of the DNA bending properties of the DNA binding proteins CRP and TFIID. Nucleic Acids Research, 20: 3391-3396. LINK TO PDF FILE

  36. Gaston, K., and Fried, M. (1992). The isolation of transcription factors from lgt11 cDNA expression libraries: human steroid 5a-reductase 1 has sequence-specific DNA binding activity. Nucleic Acids Research, 20: 6297-6301. LINK TO PDF FILE

  37. Gaston, K., Bell, A., Kolb, A., Buc, H., and Busby, S. (1990). Stringent spacing requirements for transcription activation by CRP.  Cell, 62: 733-743.

  38. Spiro, S., Gaston, K., Bell, A., Roberts, R., Guest, J., and Busby, S. (1990). Interconversion of the DNA-binding specificities of two related transcription regulators. Molecular Microbiology,  4: 1831-1838.

  39. Bell, A., Gaston, K., Williams, R., Chapman, K., Kolb, A., Buc, H., Minchin, S., Williams, J., and Busby, S. (1990). Mutations which alter the ability of the Escherichia coli cyclic AMP receptor protein to activate transcription. Nucleic Acids Research,  18: 7243-7250. LINK TO PDF FILE

  40. Bell, A., Gaston, K., Cole, J., and Busby, S. (1989). Cloning of binding sequences for the Escherichia coli transcription activators, FNR and CRP: location of bases involved in discrimination between FNR and CRP. Nucleic Acids Research, 17: 3865-3874. LINK TO PDF FILE

  41. Gaston, K., Kolb, A., and Busby, S. (1989). Binding of the Escherichia coli cyclic AMP receptor protein to DNA fragments containing consensus nucleotide sequences. Biochemical Journal, 261: 649-653.

  42. Gaston, K., Chan, B., Kolb, A., Fox, J., and Busby, S. (1988). Alterations in the binding site of the cyclic AMP receptor protein at the Escherichia coli galactose operon regulatory region.  Biochemical Journal, 253: 809-918.

  43. Jayaraman, P-S., Gaston, K., Cole, J., and Busby, S. (1988). The nirB promoter of  Escherichia coli: location of nucleotide sequences essential for regulation by oxygen, the FNR protein, and nitrite. Molecular Microbiology, 2: 527-530.

  44. Webster, C., Gaston, K., and Busby, S. (1988). Transcription from the Escherichia coli melR promoter is dependent on the cyclic AMP receptor protein. Gene, 68: 297-305.

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Chapters for books

  1. Kowalczyk, A. M, Roeder G. E., Green, K., Stevens, D. J., and Gaston, K. (2004). Measuring the induction or inhibition of apoptosis by HPV proteins. In "Human Papilloma Viruses: Methods and Protocols".  Ed. Doorbar, J. and Davy, C. Humana Press.

  2. Gaston, K. (2002). The Papillomavirus E2 Protein: A Clinical Target and Tool in the Treatment of Tumourigenesis and HPV Infection. In “ Current Topics in Virology, Vol. 2”, 195-198. Research Trends.

  3. Bell, A., Williams, R., Gaston, K., and Busby, S. (1992). Molecular interactions during transcription activation by the cyclic AMP receptor protein. In “Structural tools for the analysis of protein-DNA complexes”, 205-221. Advances in Life Sciences. Ed. Lilley, D. M. J., Heuman, H., and Suck, D.

    4.

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Patent applications
  1. Gaston, K., Stern, P. and Clarke, A.R. (2000) Methods of Inducing cell Death.  WO 01/03717 (PCT/GB00/02693).

  2. Gaston, K. (2001) Combination of Progesterone and Miferpristone for Cancer Therapy.  WO 01/82910 (PCT/GB01/01941).

  3. Gaston, K. (2002) An Inducer of Apoptosis.  WO 03/010192 (PCT/GB02/03360).

    4.
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