Publications

Below is a record of all publications which include data obtained using the Wolfson Bioimaging Facility - LM unit. You may search for an author or title using Ctrl F or follow the links below to a particular year.

Publication Year No. of Publications
2012 4
2011 25
2010 30
2009 33
2008 28
2007 33
2006 37
2005 37
2004 40
2003 42
2002 36
2001 30
2000 35
1999 23
1998 21
1997 9
1996 3

 

1996 Publications

  1. Dobson, S.P., Livingston, C., Gould, G.W. & Tavaré, J.M. (1996) Dynamics of insulin-stimulated translocation of GLUT4 in single living cells visualised using green fluorescent protein. FEBS Lett. 393: 179-184.
  2. Girotti, M. & Banting, G. (1996) TGN38-green fluorescent protein hybrid proteins expressed in stably transfected eukaryotic cells provide a tool for the real-time, in vivo study of membrane traffic pathways and suggest a possible role for rat TGN38. J. Cell Sci. 109: 2915-2926.
  3. Mitcheson, J.S., Hancox, J.C. & Levi, A.J. (1996) Action potentials, ion channel currents and transverse tubule density in adult rabbit ventricular myocytes maintained for 6 days in cell culture. Pflüger.s Arch. Eur. J. Physiol. 431: 814-827.

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    1997 Publications

  4. Banting, G. & Ponnambalam, S. (1997) TGN38 and its orthologues: roles in post-TGN vesicle formation and maintenance of TGN morphology. Biochim. Biophys. Acta 1355: 209-217.
  5. Gunn-Moore, F.J., Williams, A.G., Toms, N.J. & Tavaré, J.M. (1997) Activation of mitogen-activated protein kinase and p70S6 kinase is not correlated with cerebellar granule cell survival. Biochem. J. 324: 365-369.
  6. Soriano, S. & Banting, G. (1997) Possible roles of inositol 1,4,5-triphosphate 3-kinase B in calcium homeostasis. FEBS Lett. 403: 1-4.
  7. Mitcheson, J.S., Hancox, J.C. & Levi, A.J. (1997) Voltage dependence of the Fura-2 transient in rabbit left atrial myocytes at 37°C. Pflüger. s Arch. Eur. J. Physiol. 433: 817-826.
  8. Lockyer, P.J., Bottomley, J.R., Reynolds, J.S., McNulty, T.J., Venkateswarlu, K., Potter, B.V.L., Dempsey, C.E. & Cullen, P.J. (1997) Distinct subcellular localisations of the putative inositol 1,3,4,5-tetrakisphosphate receptors GAP1IP4BP and GAP1m result from the GAP1IP4BP PH domain directing plasma membrane targeting. Current Biology 7: 1007-1010.
  9. Oatey, P., Weering, D., Dobson, S., Gould, G. & Tavaré, J. (1997) GLUT4 vesicle dynamics in living 3T3 L1 adipocytes visualised with GFP. Biochem. J. 327: 637-642.
  10. Cullen, P.J., Loomis-Husselbee, J.W., Dawson, A.P. & Irvine, R.F. (1997) IP4 and calcium homeostasis - the role of GAP1IP4BP. Biochem. Soc. Trans. 25: 991-996.
  11. McLaughlin, E.A., Frayne, J., Barker, H.L., Jury, J.A., Jones, R., Ford, W.C.L. & Hall, L. (1997) Cloning and sequence analysis of rat fertilin alpha and beta - developmental expression, processing and immunolocalisation. Mol. Hum. Reprod. 3: 801-809.
  12. Krook, A., Whitehead, J., Dobson, S.P., Griffiths, M.R., Ouwens, M., Baker, C., Maasen, J.A., Tavaré, J.M. & O'Rahilly, S. (1997) Two naturally-occurring mutants in the insulin receptor tyrosine kinase domain provide evidence that PI3-kinase activation alone is not sufficient for the mediation of insulin's metabolic and mitogenic effects.J. Biol. Chem. 272: 30208-30214.

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    1998 Publications

  13. Pouli, A.E., Kennedy, H.J., Schofield, G.S.& Rutter, G.A. (1998) Insulin targeting to the regulated secretory pathway after fusion with green fluorescent protein and firefly luciferase. Biochem. J. 331: 669-675.
  14. Pouli, A.E., Karagenc, N., Wasmeier, C., Hutton, J.C., Bright, N., Arden, S., Schofield, G.S.& Rutter, G.A. (1998) A phogrin-aequorin chimaera to image free Ca2+ in the vicinity of secretory granules. Biochem. J. 330: 1399-1404.
  15. Venkateswarlu, K., Oatey, P.B., Tavaré, J.M. & Cullen, P.J. (1998) Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires phospatidylinositol 3-kinase. Current Biology 8: 463-466.
  16. Wainwright, S.D., Simpson, K.L. & Holmes, C.H. (1998) Calreticulin associates with non-HLA-A, -B class I proteins in the human choriocarcinoma cll lines JEG-3 and BeWo. Immunology 93: 437-445.
  17. Clark, M.A., Hirst, B.H. & Jepson, M.A.(1998) Inoculum composition and Salmonella pathogenicity island 1 regulate M cell invasion and epithelial destruction by Salmonella typhimurium. Infect. Immun. 66: 724-731.
  18. Heal, R.D. & McGivan, J.D. (1998) Induction of calreticulin expression in response to amino acid deprivation in Chinese Hamster Ovary Cells. Biochem. J. 329: 389-394.
  19. Turner, C.P., Toye, A.M. & Jones, O.T.G. (1998) Keratinocyte superoxide generation. Free Radical Biol. Med. 24: 401-407.
  20. Reed, K.A., Clark, M.A., Booth, T.A., Hueck, C.J., Miller, S.I., Hirst, B.H. & Jepson, M.A. (1998) Cell-contact-stimulated formation of filamentous appendages by Salmonella typhimurium does not depend on the type III secretion system encoded by Salmonella pathogenicity island 1. Infect. Immun. 66: 2007-2017.
  21. Scudamore, C.L., Jepson, M.A., Hirst, B.H. & Miller, H.R.P. (1998) The rat mast cell chymase, RMCP-II, alters epithelial cell monolayer permeability in association with altered distribution of the tight junction proteins ZO-1 and occludin. Eur. J. Cell Biol. 75: 321-330.
  22. Collares-Buzato, C.B., Jepson, M.A., Simmons, N.L. & Hirst, B.H. (1998) Increased tyrosine phosphorylation causes redistribution of adherens junction and tight junction proteins and perturbs paracellular barrier function in MDCK epithelia. Eur. J. Cell Biol. 76: 85-92.
  23. Wilson, M.C., Jackson, V.N., Heddle, C., Price, N.T, Pilegaard, H., Juel, C., Bonen, A., Hutter, O.F. & Halestrap, A.P (1998) Lactic acid efflux from white skeletal muscle is catalysed by the monocarboxylate transporter isoform MCT3. J. Biol. Chem. 273: 15920-15926.
  24. Robb-Gaspers, L. Burnett, P. Rutter, G.A., Rizzuto, R., Denton, R.M. & Thomas,A.P. (1998) Regulation of mitochochondrial metabolism by Ca2+-dependent hormones. EMBO J. 17: 4987-5000.
  25. Roquemore, E.P. and Banting, G. (1998) Efficient trafficking of TGN38 from the endosome to the TGN requires a free hydroxyl group at position 331 in the cytosolic domain. Mol. Biol. Cell 9: 2125-2144.
  26. Banting, G., Maile, R. & Roquemore, E.P. (1998) The steady state distribution of humTGN46 is not significantly altered in cells defective in clathrin-mediated endocytosis. J. Cell Sci. 111: 3451-3458.
  27. Pouli, A.E., Emmanouilidou, E., Wasmeier, C., Hutton J.C. and Rutter, G.A. (1998) Secretory granule dynamics visualised in vivo with a phogrin green fluorescent protein chimaera. Biochem. J. 333: 193-199.
  28. Venkateswarlu, K., Gunn-Moore, F.J., Oatey, P.B., Tavaré, J.M. & Cullen, P.J. (1998) NGF- and EGF-stimulated translocation of the ARF-exchange factor GRP1 to the plasma membrane of PC12 cells requires activation of PI 3-kinase and the GRP1 PH domain. Biochem. J. 335: 139-146.
  29. Reaves, B.J., Roquemore, E.P., Luzio, J.P. & Banting, G. (1998) TGN38 cycles via the basolateral membrane of polarised Caco-2 cells. Mol. Membrane Biol. 15: 133-140.
  30. Williams, K., Frayne, J. & Hall, L. (1998) Expression of extracellular glutathione peroxidase type 5 (GPX5) in the rat male reproductive tract. Mol. Hum. Reprod. 4: 841-848.
  31. Mitcheson, J.S., Hancox, J.C. & Levi, A.J. (1998) Cultured adult cardiac myocytes: Future applications, culture methods, morphological and electrophysiological properties. Cardiovasc. Res. 39: 280-300.
  32. Rafiq, I., Kennedy, H.J. & Rutter, G.A. (1998) Glucose-dependent translocation of insulin promoter factor-1 (IPF-1) between the nuclear periphery and the nucleoplasm of single MIN6 beta-cells.J. Biol. Chem. 273: 23241-23247.
  33. Cullen, P.J. (1998) Bridging the GAP in IP4 signalling. Biochim. Biophys. Acta 1436: 35-47.

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    1999 Publications

  34. Lockyer, P.J., Wennström, S., Kupzig, S., Venkateswarlu, K., Downward, J. & Cullen, P.J. (1999) Identification of the Ras GTPase-activating protein GAP1m as an in vivo PIP3-binding protein. Curr. Biol. 9: 265-268.
  35. Lockyer, P.J., Valingen, S., Reynolds, J.S., McNulty, T.J., Irivine, R., Parys, J.B. & Cullen, P.J. (1999) Tissue-specific expression and endogenous subcellular distribution of the inositol 1,3,4,5-tetrakisphosphate-binding proteins GAP1IP4BP and GAP1m . Biochem. Biophys. Res. Comm. 255:421-426.
  36. Kupzig, S., Lee, S.S. & Banting, G. (1999) Membrane Trafficking. In "Green Fluorescent Protein" ed. M. Conn. Methods Enzymol. 302: 3-11.
  37. Foulstone, E.J., Tavare, J.M. & Gunn-Moore, F.J. (1999) Sustained phosphorylation and activation of protein kinase B correlates with BDNF and insulin stimulated survival of cerebellar granule cells. Neurosci. Lett. 264: 125-128.
  38. Noel, J., Ralph, G.S., Pickard, L., Williams, J., Molnar, E., Uney, J.B., Collingridge, G.L. & Henley, J.M. (1999) Surface expression of AMPA receptors in hippocampal neurons is regulated by an NSF-dependent mechanism. Neuron 23: 365-376.
  39. Venkateswarlu, K., Gunn-Moore, F., Tavaré, J.M. & Cullen, P.J. (1999) EGF- and NGF-stimulated translocation of cytohesin-1 to the plasma membrane of PC12 cells requires PI 3-kinase activation and a functional cytohesin-1 PH domain. J. Cell Sci. 112: 1957-1965.
  40. Venkateswarlu, K., Oatey, P.B., Tavaré, J.M., Jackson, T.R. & Cullen, P.J. (1999) Identification of centaurin-alpha1 as a potential in vivo phosphatidylinositol3,4,5-trisphosphate-binding protein that is functionally homologous to the yeast ADP-ribosylation factor (ARF) GTPase-activating protein, gcs1. Biochem. J. 340: 359-363.
  41. Emmanouilidou, E., Teschemacher, A.G., Pouli, A.E., Nicholls, L.I., Seward, E.P., Rutter, G.A. (1999) Imaging Ca2+ concentration changes at the secretory vesicle surface with a recombinant targeted cameleon. Curr. Biol. 9: 915-918.
  42. Gampel, A., Parker, P.J. & Mellor, H. (1999) Regulation of EGF receptor traffic by the small GTPase rhoB. Curr. Biol. 9: 955-958.
  43. Venkateswarlu, K. & Cullen, P.J. (1999) Molecular cloning and functional characterization of a human homologue of centaurin-. Biochem. Biophys. Res. Commun. 262: 237-244.
  44. Stephens, D.J. & Banting, G. (1999) Direct interaction of the trans Golgi network membrane protein TGN38 with the F-actin binding protein neurabin. J. Biol. Chem. 274: 30080-30086.
  45. Toms, N.J. & Roberts, P.J. (1999) Group 1 mGlu receptors elevate [Ca2+]i in rat cultured cortical type 2 astrocytes: [Ca2+]i synergy with adenosine A1 receptors Neuropharmacology 38: 1511-1517.
  46. Veropoulos, K., Learmonth, G., Campbell, C., Knight, B. & Simpson, J. (1999) Automated identification of tubercle bacilli in sputum. A preliminary investigation. Anal. Quant. Cytol. Histol. 21: 277-282.
  47. Halestrap, A.P. & Price, N.T. (1999) The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Biochem. J. 343: 281-299.
  48. Oatey, P.B., Venkateswarlu, K., Williams, A.G., Fletcher, L.M., Foulstone, E.J., Cullen, P.J. & Tavaré, J.M. (1999) Confocal imaging of the subcellular distribution of phosphatidylinositol 3,4,5-trisphosphate in insulin- and PDGF-stimulated 3T3-L1 adipocytes. Biochem. J. 344: 511-518.
  49. Semenenko, F.M. & Lumb, B.M. (1999) Excitatory projections from the anterior hypothalamus to periaqueductal gray neurons that project to the medulla: a functional anatomical study. Neuroscience 94: 163-174.
  50. Kennedy, H.J., Pouli, A.E., Ainscow, E.K., Jouaville, L.S., Rizzuto, R. & Rutter, G.A. (1999) Glucose generates sub-plasma membrane ATP microdomains in single islet b -cells. Potential role for strategically located mitochondria. J. Biol. Chem. 274: 13281-13291.
  51. Foran, P.G., Fletcher, L.M., Oatey, P.B., Mohammed, N., Dolly, J.O. & Tavaré, J.M. (1999) Protein kinase B stimulates the translocation of GLUT4 but not GLUT1 or transferrin receptors in 3T3-L1 adipocytes by a pathway involving SNAP-23, synaptobrevin-2, and/or cellubrevin. J. Biol. Chem. 274: 28087-28095.
  52. Fletcher, L.M. & Tavaré, J.M. (1999) Divergent signalling mechanisms involved in insulin-stimulated GLUT4 vesicle trafficking in the plasma membrane. Biochem. Soc. Trans. 27: 671-683.
  53. Cullen, P.J. & Venkateswarlu, K. (1999) The potential regulation of ADP-ribosylation factor 6 signalling by phosphatidylinositol 3,4,5-trisphosphate. Biochem. Soc. Trans. 27: 683-689.
  54. Mihai, R., Lai, T., Schofield, G. & Farndon, J.R. (1999) Thimerosal increases the responsiveness of the calcium receptor in human parathyroid and rMTC6-23 cells. Cell Calcium 26: 95-101.
  55. Stewart, C.E., Mihai, R. & Holly, J.M. (1999) Increased tyrosine kinase activity but not calcium mobilization is required for ceramide-induced apoptosis. Exp. Cell Res. 250: 329-338.
  56. Juel, C. & Halestrap, A.P. (1999) Lactate transport in skeletal muscle - role and regulation of the monocarboxylate transporter. J. Physiol. (Lond.), 517: 633-642.

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    2000 Publications

  57. Stephens, D.J. and Banting, G. (2000) In vivo dynamics of the F-actin binding protein neurabin-II. Biochem. J. 345: 185-194.
  58. Fouchet, C., Gane, P., Huet, M., Fellous, M., Rouger, P., Banting, G., Cartron, J-P. & Lopez, C. (2000) A study of the coregulation and tissue specificity of XG and MIC2 gene expression in eukaryotic cells. Blood 95: 1819-1826.
  59. Venkateswarlu, K. & Cullen, P.J. (2000) Signalling via ADP-ribosylation factor 6 lies downstream of phosphatidylinositide 3-kinase. Biochem. J. 345: 719-724.
  60. Brooks, P., Fuertes, G., Murray, R.Z., Bose, S., Knecht, E., Rechsteiner, M.C., Hendil, K.B., Tanaka, K., Dyson, J. & Rivett, J. (2000) Subcellular localization of proteasomes and their regulatory complexes in mammalian cells. Biochem. J. 346: 155-161.
  61. Popovik, E. & Haynes, L.W. (2000) Survival and mitogenesis of neuroepithelial cells are influenced by noradrenergic but not cholinergic innervation in cultured embryonic rat neopallium. Brain Res. 853: 227-235.
  62. Webster, K., Parish, J., Pandya, M., Stern, P.L., Clarke, A.R. & Gaston, K. (2000) The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway. J. Biol. Chem. 275: 87-94.
  63. Ellis, S. & Mellor, H. (2000) Regulation of endocytic traffic by Rho family GTPases. Trends Cell. Biol. 10: 85-88.
  64. Maile, R., Elsegood, K.A., Harding, T.C., Uney, J.B., Stewart, C.E.H., Banting, G. & Dayan, C.M. (2000) Effective formation of MHC Class II-peptide complexes from endogenous antigen by thyroid epithelial cells. Immunology 99: 367-374.
  65. da Silva Xavier, G., Leclerc, I., Salt, I., Doiron, B., Hardie, D.G., Kahn, A. & Rutter, G.A. (2000) Role of AMPK in the regulation by glucose of islet b -cell gene expression. Proc. Natl. Acad. Sci. 97: 4023-4028.
  66. Flynn, P., Mellor, H., Casamassima, A. & Parker, P.J. (2000) Rho-GTPase control of PRK activation by PDK1. J. Biol. Chem. 275: 11064-11070.
  67. Mihai, R., Lai, T., Schofield, G. & Farndon, J.R. (2000) C2-Ceramide increases cytoplasmic calcium concentrations in human parathyroid cells. Biochem. Biophys. Res. Commun. 268: 636-641.
  68. Seaton, G.J., Hall, L. & Jones, R. (2000) Rat sperm 2B1 glycoprotein (PH20) contains a C-terminal sequence motif for attachment of a glycosyl phosphatidylinositol anchor. effects of endoproteolytic cleavage on hyaluronidase activity. Biol. Reprod. 62: 1667-1676.
  69. Rafiq, I., da Silva Xavier, G., Hooper, S. & Rutter, G.A. (2000) Glucose-stimulated preproinsulin gene expression and nuclear translocation of pancreatic duodenum homeobox-1 (PDX-1), require activation of phosphatidyl inositol 3-kinase but not p38 MAPK/SAPK2. J. Biol. Chem. 275: 15977-15984.
  70. Virji, M., Evans, D., Griffith, J., Hill, D., Serino, L., Hadfield, A., Watt, SM. (2000) Carcinoembryonic antigens are targeted by diverse strains of typable and non-typable Haemophilus influenzae. Mol. Microbiol. 36: 784-795.
  71. de Bree, F.M. (2000) Trafficking of the vasopressin and oxytocin prohormone through the regulated secretory pathway. J. Neuroendocrinol. 12: 589-594.
  72. Crew, T.E., Elder, D.J.E. & Paraskeva, C. (2000) A cyclooxygenase-2 (COX-2) selective non-steroidal anti-inflammatory drug enhances the growth inhibitory effect of butyrate in colorectal carcinoma cells expressing COX-2 protein: regulation of COX-2 by butyrate. Carcinogenesis, 21: 69-77.
  73. de Bree, F.M., Knight, D., Howell, L.M.C. & Murphy, D. (2000) Sorting of the vasopressin prohormone into the regulated secretory pathway. FEBS Lett. 475: 175-180.
  74. Si-Hoe, S.-L., de Bree, F.M., Nijenhuis, M., Davies, J.E., Howell, L.M.C., Tinley, H., Waller, S.J., Zeng, Q., Zalm, R., Sonnemans, M., van Leeuwen, F.W., Burbach, J.P.H. & Murphy, D. (2000). Endoplasmic reticulum derangement in hypothalamic neurons of rats expressing a familial neurohypophyseal diabetes insipidus mutant vasopressin transgene. FASEB J. 14: 1680-1684.
  75. Hinton, J.M., Hill, P.B., Jeremy, J.Y. & Garland, C.J. (2000) Characterisation of 5-HT1B/5-HT1D receptors of rabbit renal artery smooth muscle cells in isolated vessels and primary culture. J. Vascular Res., 37: 457-468.
  76. Ainscow, E.K., Zhao, C.& Rutter G.A. (2000) Acute over-expression of LDH-A perturbs glucose stimulated mitochondrial metabolism and insulin secretion. Diabetes, 49: 1149-1155.
  77. Cozier, G.E., Lockyer, P.J., Reynolds, J.S., Kupzig, S., Bottomley, J.R., Millard, T.H., Banting, G. & Cullen, P.J. (2000) GAP1IP4BP contains a novel Group I pleckstrin homology domain that directs constitutive plasma membrane association. J. Biol. Chem., 275: 28261-28268.
  78. da Silva Xavier, G., Varadi, A., Ainscow, E.K. & Rutter, G.A. (2000) Regulation of gene expression by glucose in pancreatic b -cells (MIN6) via insulin secretion and activation of phosphatidylinositol 3'-kinase. J. Biol. Chem. 275: 36269-36277.
  79. Fletcher, L.M., Welsh, G.I., Oatey, P.B. & Tavaré, J.M. (2000) Role for the microtubule cytoskeleton in GLUT4 vesicle trafficking and in the regulation of insulin-stimulated glucose uptake. Biochem. J. 352: 267-276.
  80. Mihai, R., Lai, T., Schofield, G.J. & Farndon, J.R. (2000) Changes in cytoplasmic calcium determine the secretory response to extracellular cations in human parathyroid cells: a confocal microscopy study using FM1-43 dye. Biochem. J. 352: 353-361.
  81. Kirk, P., Wilson, M.C., Heddle, C., Brown, M.H., Barclay, A.N. & Halestrap, A.P. (2000) CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression. EMBO J., 19: 3896-3904.
  82. Kenny, B. & Jepson, M.A. (2000) Targeting of an enteropathogenic E. coli effector protein to host mitochondria. Cellular Microbiol., 2: 579-590.
  83. Tyas, L., Brophy, V.A., Pope, A., Rivett, A.J. & Tavaré, J.M. (2000) Rapid caspase-3 activation during apoptosis revealed using fluorescence- resonance energy transfer. EMBO Reports, 1: 266-270.
  84. Ellis, S. & Mellor, H. (2000) Novel Rho GTPase Rif Regulates Co-ordinated Actin-Based Membrane Rearrangements. Curr. Biol., 10: 1387-1390.
  85. Jepson, M.A., Schlecht, H.B. & Collares-Buzato, C.B. (2000) Localization of dysfunctional tight junctions in Salmonella enterica serovar Typhimurium- infected epithelial layers.Infect. Immun., 68: 7202-7208.
  86. Pickard, L., Noel, J., Henley, J. M., Collingridge, G. L. & Molnar, E. (2000) Developmental changes in synaptic AMPA and NMDA receptor distribution and AMPA receptor subunit composition in living hippocampal neurons. J. Neurosci., 20: 7922-7931.
  87. Popovik, E. & Haynes, L.W. (2000) Noradrenergic but not cholinergic innervation of the embryonic cortical neuroepithelium rescues germinal and postmitotic cells in heterochronic cocultures. Brain Res., 853: 227-235.
  88. Tsuboi, T., Zhao, C., Terakawa, S. & Rutter, G.A. (2000) Simultaneous evanescent wave imaging of insulin vesicle membrane and cargo during a single exocytotic event. Curr. Biol., 10: 1307-1310.
  89. Manning Fox, J.E., Meredith, D. & Halestrap, A.P. (2000) Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle. J. Physiol., 529: 285-293.
  90. Brooks, P., Murray, R.Z., Mason, G.G., Hendil, K.B. & Rivett, A.J. (2000) Association of immunoproteasomes with the endoplasmic reticulum. Biochem. J,, 352: 611-615.
  91. Mundell, S.J., Matharu, A.L., Kelly, E. & Benovic, J.L. (2000) Arrestin isoforms dictate differential kinetics of A2B adenosine receptor trafficking. Biochemistry, 39: 12828-12836.

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    2001 Publications

  92. Webster, K., Taylor, A. & Gaston, K. (2001) Oestrogen and progesterone increase the levels of apoptosis induced by the human papillomavirus type 16 E2 and E7 proteins. J. Gen. Virol., 82: 201-213.
  93. Sampson, L.J., Hinton, J.M. & Garland, C.J. (2001) Evidence for expression and function of phosphodiesterase type 5 (PDE-V) in rat resistance arteries. Br. J. Pharmacol., 132: 13-17.
  94. Ainscow, E.K., & Rutter, G,A. (2001) Mitochondrial priming modifies Ca2+ oscillations and insulin secretion in pancreatic islets. Biochem. J., 353: 175-180.
  95. Jepson, M.A., Kenny, B. & Leard, A.D. (2001) Role of sipA in the early stages of Salmonella typhimurium entry into epithelial cells. Cellular Microbiol., 3: 417-426.
  96. Bobe, R., Wilde, J.I., Maschberger, P., Venkateswarlu, K., Cullen, P.J., Siess, W. & Watson, S.P. (2001) Phosphatidylinositol 3-kinase-dependent translocation of phospholipase Cg 2 in mouse megakaryocytes is independent of Bruton tyrosine kinase translocation. Blood, 97: 678-684.
  97. Paton, J.F., Deuchars, J., Ahmad, Z., Wong, L.F., Murphy, D. & Kasparov, S. (2001) Adenoviral vector demonstrates that angiotensin II-induced depression of the cardiac baroreflex is mediated by endothelial nitric oxide synthase in the nucleus tractus solitarii of the rat. J. Physiol. 531: 445-458.
  98. Yeo, A., Samways, D.S.K., Fowler, C.E., Gunn-Moore, F. & Henderson, G. (2001) Coincident signalling between the Gi/Go-coupled -opioid receptor and the Gq-coupled m3 muscarinic receptor at the level of intracellular free calcium in SH-SY5Y cells. J. Neurochem. 76: 1688-1700.
  99. Zhao, C., Wilson, M.C., Schuit, F., Halestrap, A.P. & Rutter, G.A. (2001) Expression and distribution of lactate/monocarboxylate transporter isoforms in pancreatic islets and the exocrine pancreas. Diabetes, 50: 361-366.
  100. Crewe, J.M. & Armitage, W.J. (2001) Integrity of epithelium and endothelium in organ-cultured human corneas. Invest. Ophth. Vis. Sci., 42: 1757-1761.
  101. Lockyer, P.J., Kupzig, S. & Cullen, P.J. (2001) CAPRI regulates Ca2+-dependent inactivation of the Ras-MAPK pathway. Curr. Biol., 11: 981-986.
  102. Millar, D.G. & Hirst, T.R. (2001) Cholera toxin and Escherichia coli enterotoxin B-subunits inhibit macrophage-mediated antigen processing and presentation: evidence for antigen persistence in non-acidic recycling endosomal compartments. Cellular Microbiol., 3: 311-329.
  103. Vernon, E., Meyer, G., Pickard, L., Dev, K., Molnar, E., Collingridge, G.L. & Henley, J.M. (2001) GABA(B) receptors couple directly to the transcription factor ATF4. Mol Cell Neurosci., 17: 637-645.
  104. Ralph, G.S., Bienemann, A., Ma, J., Tan, H.K., Noel, J., Henley, J.M. & Uney, J.B. (2001) Disruption of the GluR2-NSF interaction protects primary hippocampal neurons from ischemic stress. Mol.Cell. Neurosci., 17: 662-670.
  105. Tavaré, J.M., Fletcher, L.M., Oatey, P.B., Tyas, L., Wakefield, J.G. & Welsh, G.I. (2001) Lighting up insulin action. Diabet. Med., 18: 253-260.
  106. Aman, A.T., Fraser, S., Merritt, E.A., Rodigherio, C., Kenny, M., Ahn, M., Hol, W.G., Williams, N.A., Lencer, W.I. & Hirst, T.R. (2001) A mutant cholera toxin B subunit that binds GM1-ganglioside but lacks immunomodulatory or toxic activity. Proc. Natl. Acad. Sci. U.S.A., 98: 8536-8541.
  107. Matharu, A.L., Mundell, S.J., Benovic, J.L. & Kelly, E. (2001) Rapid agonist-induced desensitization and internalization of the A2B adenosine receptor is mediated by a serine residue close to the C-terminus. J. Biol. Chem., 276: 30199-30207.
  108. Mundell, S.J., Matharu, A-L., Pula, G., Roberts, P.J. & Kelly, E. (2001) Agonist-induced internalization of the metabotropic glutamate receptor 1a is arrestin- and dynamin-dependent. J. Neurochem., 78: 546-551.
  109. Tavaré, J.M., Fletcher, L.M., Welsh, G.I. (2001) Using green fluorescent protein to study intracellular singnalling. J. Endocrinol., 170: 297-306.
  110. Heesom, K.J, Gampel, A., Mellor, H. & Denton, R.M. (2001) Cell cycle-dependent phosphorylation of the translational repressor of eIF-4E binding protein-1 (4E-BP1). Current Biology 11: 1374-1379.
  111. O'Toole, A., Moule, S.K., Lockyer, P.J. & Halestrap, A.P. (2001) Tumour necrosis factor-alpha activation of protein kinase B in WEHI-164 cells is accompanied by increased phosphorylation of Ser473, but not Thr308. Biochem. J. 359: 119-127.
  112. Pattni, K., Jepson, M.A., Stenmark, H. & Banting, G. (2001) A PtdIns(3) P-specific probe cycles on and off host cell membranes during Salmonella invasion of mammalian cells. Current Biology 11: 1636-1642.
  113. Pickard, L., Noel, J., Duckworth, J. K., Fitzjohn, S. M., Henley, J. M., Collingridge, G. L. & Molnar, E. (2001) Transient synaptic activation of NMDA receptors leads to the insertion of native AMPA receptors into hippocampal neuronal plasma membrane. Neuropharmacology 41: 700-713.
  114. Mitchell, K.J., Pinton, P., Varadi, A., Tacchetti, C., Ainscow, E.K., Pozzan, T., Rizzuto, R. & Rutter, G.A. (2001) Dense core secretory vesicles revealed as a dynamic Ca2+ store in neuroendocrine cells with a vesicle-associated membrane protein aequorin chimaera. J. Cell Biol. 155: 41-52.
  115. Clark, M.A., Jepson, M.A. & Hirst, B.H..(2001) Exploiting M cells for drug and vaccine delivery. Adv. Drug Deliv. Rev. 50: 81-106.
  116. Kenny, B. (2001) The enterohaemorrhagic Escherichia coli (serotype O157:H7) Tir molecule is not functionally interchangeable for its enteropathogenic E. coli (serotype O127:H6) homologue. Cell. Microbiol. 3: 499-510.
  117. Coutinho,V., Kavanagh, I., Sugiyama, H., Tones, M.A., Henley, J.M. (2001) Characterization of a metabotropic glutamate receptor type 5-green fluorescent protein chimera (mglur5-gfp): pharmacology, surface expression, and differential effects of homer-1a and homer-1c. Mol. Cell. Neurosci. 8: 296-306.
  118. Warawa, J. & Kenny, B. (2001) Phosphoserine modification of the enteropathogenic Escherichia coli Tir molecule is required to trigger conformational changes in Tir and efficient pedestal elongation. Mol. Microbiol. 42: 1269-1280.
  119. Cullen, P.J., Cozier, G.E., Banting, G. & Mellor, H. (2001) Modular phosphoinositide-binding domains – their role in signalling and membrane trafficking. Current Biology 11: R882-R893.
  120. Bowden, S.E.H., Fletcher, S., Loane, D.J. & Marrion, N.V. (2001) Somatic co-localization of rat SK1 and D class (Cav 1.2) L-type calcium channels in rat CA1 hippocampal pyramidal neurons. J. Neurosci. 21 (RC175): 1-6.
  121. Dev, K.K., Nakanishi, S. & Henley, J.M. (2001) Regulation of mglu(7) receptors by proteins that interact with the intracellular C-terminus. Trends Pharmacol. Sci. 22: 355-361.

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    2002 Publications

  122. Toye, A.M., Bruce, L.J., Unwin, R.J., Wrong, O. & Tanner, M.J. (2002) Band 3 Walton, a C-terminal deletion associated with distal renal tubular acidosis, is expressed in the red cell membrane but retained internally in kidney cells. Blood 99: 342-347.
  123. Molnar, E., Isaac, J.T.R. (2002) Developmental and activity dependent regulation of ionotropic glutamate receptors at synapses. The ScientificWorld Journal 2: 27-47. URL:http://www.thescientificworld.com
  124. Wilson, M.C., Meredith, D. & Halestrap, A.P. (2002) Fluorescence resonance energy transfer studies on the interaction between the lactate transporter MCT1 and CD147 provide information on the topology and stoichiometry of the complex in situ. J. Biol. Chem. 277: 3666-3672.
  125. Molnar, E., Pickard, L. & Duckworth, J. K. (2002) Developmental changes in ionotropic glutamate receptors: Lessons from hippocampal synapses. Neuroscientist 8: 144-154.
  126. Varadi, A. & Rutter, G.A. (2002) Dynamic imaging of endoplasmic reticulum Ca2+ concentration in MIN6 cells using recombinant targeted cameleons: roles of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-2 and ryanodine receptors.Diabetes 51 Suppl 1: S190-S201.
  127. Ainscow, E.K. & Rutter, G.A. (2002) Glucose-stimulated oscillations in free cytosolic ATP concentration imaged in single islet B-cells: Evidence for a Ca(2+)-dependent mechanism. Diabetes 51 Suppl. 1: S162-S170.
  128. Brophy,V.A., Tavare, J.M. & Rivett, A.J. (2002) Treatment of COS-7 cells with proteasome inhibitors or gamma-interferon reduces the increase in caspase 3 activity associated with staurosporine-induced apoptosis. Arch. Biochem. Biophys. 397: 199-205.
  129. Kenny B. (2002) Mechanism of action of EPEC Type III effector molecules. Int. J. Med. Micro. 291: 469-477.
  130. Nicholls, L.I., Ainscow, E.K. & Rutter, G.A. (2002) Glucose-stimulated insulin secretion does not require activation of pyruvate dehydrogenase: Impact of adenovirus-mediated overexpression of PDH kinase and PDH phosphate phosphatase in pancreatic islets. Biochem. Biophys. Res. Commun. 291: 1081-1088.
  131. Soriani, M., Bailey, L. & Hirst, T.R. (2002) Contribution of the ADP-ribosylating and receptor-binding properties of cholera-like enterotoxins in modulating cytokine secretion by human intestinal epithelial cells. Microbiology 148: 667-676.
  132. Davies, D. & Holley, M.C. (2002) Differential expression of a 3 and a 6 integrins in the developing mouse inner ear. J. Comp. Neurol. 445: 122-132.
  133. Hirbec, H., Perestenko, O., Nishimune, A., Meyer, G., Nakanishi, S., Henley, J.M. & Dev, K.K. (2002) The PDZ proteins PICK1, GRIP and syntenin bind multiple glutamate receptor subtypes: Analysis of PDZ binding motifs. J. Biol. Chem. 277: 15221-15224.
  134. Hague, A., Packham, G., Huntley, S., Shefford, K. & Eveson, J.W. (2002) Deregulated Bag-1 protein expression in human oral squamous cell carcinomas and lymph node metastases. J. Pathol. 197: 60-71.
  135. Kenny, B., Ellis, S., Leard, A.D., Warawa, J., Mellor, H. & Jepson, M.A. (2002) Co-ordinate regulation of distinct host cell signalling pathways by multifunctional Enteropathogenic E. coli (EPEC) effector molecules. Mol. Microbiol. 44: 1095-1107.
  136. Mundell, S.J., Matharu, A.L., Pula, G., Holman, D., Roberts, P.J. & Kelly, E. (2002) Metabotropic glutamate receptor 1 internalization induced by muscarinic acetylcholine receptor activation: differential dependency of internalization of splice variants on nonvisual arrestins. Mol. Pharmacol. 61: 1114-1123.
  137. McArdle, C.A., Franklin, J., Green, L. & Hislop, J.N. (2002)Signalling, cycling and desensitisation of gonadotrophin-releasing hormone receptors. J. Endocrinol. 173: 1-11.
  138. De Haan, L., Hearn, A.R., Rivett, A.J. & Hirst, T.R. (2002) Enhanced delivery of exogenous peptides into the class I antigen processing and presentation pathway. Infect. Immun. 70: 3249-3258.
  139. Varadi, A., Ainscow, E.K., Allan, V.J. & Rutter, G.A. (2002) Molecular mechanisms involved in secretory vesicle recruitment to the plasma membrane in beta-cells. Biochem. Soc. Trans. 30: 328-332.
  140. Harrison, O.B., Robertson, B.D., Faust, S.N., Jepson, M.A., Goldin, R.D., Levin, M. & Heyderman, R.S. (2002) Analysis of pathogen-host cell interactions in purpura fulminans: expression of capsule, type IV pili and PorA by Neisseria meningitidis in vivo. Infect. Immun. 70: 5193-5220.
  141. Varadi, A. & Rutter, G.A. (2002) Calcium Biosensors - GFP cameleons. In GFP applications and protocols (Ed. B.W. Hicks) Methods Mol. Biol. 20: 3-11.
  142. Ducluzeau, P.H., Fletcher, L.M., Welsh, G.I & Tavaré, J.M. (2002) Functional consequence of targeting protein kinase B/Akt to GLUT4 vesicles. J. Cell Sci.. 115: 2857-2866.
  143. Kenny, B. (2002) Enteropathogenic Escherichia coli (EPEC)-a crafty subversive little bug. Microbiology 148: 1967-1978.
  144. Hackett, L., Davies, D., Helyer, R., Kennedy, H., Kros, C., Lawlor, P., Rivolta, M.N. & Holley, M. (2002) E-cadherin and the differentiation of mammalian vestibular hair cells. Exp. Cell Res. 278: 19-30.
  145. Pinton, P., Tsuboi, T., Ainscow, E.K., Pozzan, T., Rizzuto, R. & Rutter, G.A. (2002) Dynamics of glucose-induced membrane recruitment of protein kinase C bII in living pancreatic islet beta-cells. J. Biol. Chem. 277: 37702-37710.
  146. Glover, C.P., Bienemann, A.S., Heywood, D.J., Cosgrave, A.S. & Uney, J.B. (2002) Adenoviral-mediated, high-level, cell-specific transgene expression: a SYN1-WPRE cassette mediates increased transgene expression with no loss of neuron specificity. Mol. Ther. 5: 509-516.
  147. Cozier, G.E., Carlton, J., McGregor, A.H., Glesson, P.A., Teasdale, R.D., Mellor, H. & Cullen, P.J. (2002) The PX domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation. J. Biol.Chem. 277: 48730-48736.
  148. Varadi, A., Ainscow, E.K., Allan, V.J. & Rutter, G.A. (2002) Involvement of conventional kinesin in glucose-stimulated secretory granule movements and exocytosis in clonal pancreatic b-cells. J. Cell Sci. 115: 4177-4189.
  149. Walker, S.A., Kupzig, S., Lockyer, P.J., Bilu, S., Zharhary, D. & Cullen, P.J. (2002) Analysing the role of the putative inositol 1,3,4,5-tetrakisphosphate receptor GAP1IP4BP in intracellular Ca2+ homeostasis. J. Biol. Chem. 277: 48779-48785.
  150. Saleem, M.A., Ni, L., Witherden, I., Tryggvason, K., Ruotsalainen, V., Mundel, P. & Mathieson, P.W. (2002) Co-localization of nephrin, podocin, and the actin cytoskeleton: evidence for a role in podocyte foot process formation. Am. J. Pathol. 161: 1459-1466.
  151. Ainscow, E.K., Mirshamsi, S., Tang, T., Ashford, M.L.J. & Rutter, G.A. (2002) Dynamic imaging of free cytosolic ATP concentration during fuel sensing by rat hypothalamic neurones: evidence for ATP-independent control of ATP-sensitive K+ channels. J Physiol (Lond), 544: 429-445.
  152. Beckmann, R., Toye, A.M., Smythe, J.S., Anstee, D.J. & Tanner, M.J. (2002) An N-terminal GFP tag does not alter the functional expression to the plasma membrane of red cell and kidney anion exchanger (AE1) in mammalian cells. Mol. Membr. Biol. 19: 187-200.
  153. Gampel, A. & Mellor, H. (2002) Small interfering RNAs as a tool to assign Rho GTPase exchange-factor function in vivo. Biochem. J. 366: 393-398.
  154. Lee, S.S. & Banting, G. (2002) Characterisation of the lumenal domain of TGN38 and effects of elevated expression of TGN38 on glycoprotein secretion. Eur. J. Cell Biol. 81: 609-621.
  155. Davies, J. & Murphy, D. (2002) Autophagy in hypothalamic neurons of rats expressing a familial neurohypophysial diabetes insipidus transgene. J. Neuroendocrinol. 14: 629-637.
  156. Mircescu, H., Steuve, S., Savonet, V., Degraef, C., Mellor, H., Dumont, J.E., Maenhaut, C., Pirson, I. (2002) Identification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMP. Eur. J. Biochem. 269: 6241-6249.
  157. De La Rue, S.A. & Henley, J.M. (2002) Proteins involved in the trafficking and functional synaptic expression of AMPA and KA receptors. ScientificWorldJournal 2: 461-482.

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    2003 Publications

  158. Wong L-F and Murphy D (2003) Adenoviral-mediated over-expression of Brn2 in the rat paraventricular nucleus: no effect on vasopressin or corticotrophin releasing factor RNA levels. Mol Cell Endocrinol. 28: 165-175.
  159. Wakefield, J.G., Stephens, D.J. & Tavaré, J.M. (2003) A role for glycogen synthase kinase-3 in mitotic spindle dynamics and chromosome alignment. J.Cell Sci. 116: 637-646.
  160. Mitchell, K.J., Lai, F.A. & Rutter, G.A. (2003) Ryanodine receptor type I and nicotinic acid adenine dinucleotide phosphate (NAADP) receptors mediate Ca2+ release from insulin-containing vesicles in living pancreatic beta-cells (MIN6). J. Biol. Chem. 278: 11057-64.
  161. Buda, A., Qualtrough, D., Jepson, M.A., Martines, D., Paraskeva, C. & Pignatelli, M. (2003) Butyrate down-regulates alpha2, beta1 integrin: A possible role in the induction of apoptosis in colorectal cancer cell lines. Gut 52: 729-734.
  162. Lauri, S.E., Lamsa, K., Pavlov, I., Riekki, R., Johnson, B., Molnar, E., Rauvala, H., Taira, T. (2003) Activity blockade increases the number of functional synapses in the hippocampus of newborn rats. Mol. Cell. Neurosci. 22: 107-117.
  163. Luyt, K., Varadi, A., Molnar, E. (2003) Functional metabotropic glutamate receptors are expressed in oligodendrocyte progenitor cells. J. Neurochem. 84: 1452-1464.
  164. Ong, K.W., Wilson, A.D., Hirst, T.R. & Morgan, A.J. (2003) The B-subunit of Escherichia coli heat-labile enterotoxin (EtxB) enhances CD8+ cytotoxic T-lymphocyte killing of Epstein-Barr virus-infected cell lines. J. Virol. 77: 4298-4305.
  165. Fraser, S.A., De Haan, L., Hearn, A.R., Bone, H.K., Salmond, R.J., Rivett, A.J., Williams, N.A. & Hirst, T.R. (2003) A mutant E. coli heat-labile toxin B subunit that separates toxoid-mediated signalling and immunomodulatory action from trafficking and delivery functions. Infect. Immun. 71: 1527-1537.
  166. Clark, M.A. & Jepson, M.A. (2003) Intestinal M cells and their role in bacterial infection. Int. J. Med. Microbiol. 293: 17-39.
  167. Fletcher, S., Bowden, S.E.H. & Marrion, N.V. (2003) False interaction of syntaxin 1A with a Ca2+-activated K+ channel revealed by co-immunoprecipitation and pull-down assays: Implications for identification of protein:protein interactions. Neuropharm. 44: 814-827.
  168. Banbury, D.N., Oakley, J.D., Sessions, R.B. & Banting, G. (2003) Tyrphostin A23 inhibits internalisation of the transferrin receptor by perturbing the interaction between tyrosine motifs and the medium chain subunit of the AP-2 adaptor complex. J. Biol. Chem. 278: 12022-8.
  169. Mundell, S.J., Pula, G., Carswell, K., Roberts, P.J. & Kelly, E. (2003) Agonist-induced internalization of metabotropic glutamate receptor 1A: structural determinants for protein kinase C- and G protein-coupled receptor kinase-mediated internalization. J. Neurochem. 84: 294-304.
  170. Ghadessy, R.S., Willets, J.M. & Kelly, E. (2003) G protein-coupled receptor kinase 6 (GRK6) selectively regulates endogenous secretin receptor responsiveness in NG108-15 cells. Br. J. Pharmacol. 138: 660-670.
  171. Stephens, D.J. (2003) De novo formation, fusion and fission of mammalian COPII-coated endoplasmic reticulum exit sites. EMBO Reports 4: 210-217.
  172. Tsuboi, T. & Rutter, G.A. (2003) Multiple forms of "Kiss-and-Run" exocytosis revealed by evanescent wave microscopy. Curr Biol. 13: 563-567.
  173. Jepson, M.A. (2003) Disruption of epithelial barrier function by H2O2: Distinct responses of Caco-2 and MDCK strains. Cell. Mol. Biol. 49: 101-112.
  174. La Ragione, R.M., Cooley, W.A., Jepson, M.A., & Woodward, M.J. (2003) Membrane ruffling and invasion of human and avian cell lines is reduced for aflagellate mutants of Salmonella enterica serotype Enteritidis. Int. J. Med. Microbiol. (in press).
  175. Olivera, S., Rodriguez-Ithurralde, D. & Henley, J.M. (2003) Acetylcholinesterase promotes neurite elongation, synapse formation, and surface expression of AMPA receptors in hippocampal neurones. Mol. Cell. Neurosci. 23: 96-106.
  176. Arhel, N.J., Packham, G., Townsend, P.A., Collard, T.J., H-Zadeh, A.M., Sharp, A., Cutress, R.I., Malik, K., Hague, A., Paraskeva, C. & Williams, A.C. The retinoblastoma protein interacts with Bag-1 in human colonic adenoma and carcinoma derived cell lines. Int. J. Cancer 106: 364-371.
  177. Hirbec, H., Francis, J.C., Lauri, S.E., Braithwaite, S.P., Coussen, F., Mulle, C., Dev, K.K., Couthino, V., Meyer, G., Isaac, J.T.R., Collingridge, G.L. & Henley, J.M. (2003) Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP. Neuron 37: 625-638.
  178. Perestenko, P., Ashby, M.C. & Henley, J.M. (2003) Real-time imaging of AMPA receptor movements in neurons. Biochem. Soc. Trans. 31: 880-884.
  179. Samways, D.S., Li, W.H., Conway, S.J., Holmes, A.B., Bootman, M.D. & Henderson, G. (2003) Co-incident signalling between m-opioid and M3-muscarinic receptors at the level of Ca2+ release from intracellular stores: lack of evidence for InsP3 receptor sensitisation. Biochem. J. 375: 713-720.
  180. Cozier, G.E., Bouyoucef, D. & Cullen, P.J. (2003) Engineering the phosphoinositide-binding profile of a class I pleckstrin homology (PH) domain. J. Biol. Chem. 278: 39489-39496.
  181. Gallyas, F., Ball, S.M. & Molnar, E. (2003) Assembly and cell surface expression of KA-2 subunit-containing kainite receptors. J. Neurochem. 86: 1414-1427.
  182. Jepson, M.A., Pellegrin, S., Peto, L., Banbury, D.N., Leard, A.D., Mellor, H. & Kenny, B. (2003) Synergistic roles for the Map and Tir effector molecules in mediating uptake of enteropathogenic E. coli (EPEC) into non-phagocytic cells. Cell. Microbiol. 5: 773-783.
  183. Friesema, E.C., Ganguly, S., Abdalla, A., Manning-Fox, J.E., Halestrap, A.P. & Visser, T.J. (2003) Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter. J. Biol. Chem. 278: 40128-40135.
  184. Perestenko, P.V. & Henley, J.M. (2003) Characterisation of the intracellular transport of GluR1 and GluR2 alpha -amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) subunits in hippocampal neurons. J. Biol. Chem. 278: 43525-32.
  185. Venkateswarlu, K. (2003) Interaction protein for cytohesin exchange factors (IPCEF)1 binds cytohesin 2 and modifies its activity. J. Biol. Chem.278: 43460-9.
  186. Pattni, K., Millard, T.H. & Banting, G. (2003) Calpain cleavage of the B isoform of IP3 3-kinase separates the catalytic domain from the membrane anchoring domain. Biochem. J. 375: 643-51.
  187. Kupzig, S., Korolchuk, V., Rollason, R., Sugden, A., Wilde, A. & Banting, G. (2003) Bst-2/HM1.24 is a raft-associated apical membrane protein with an unusual topology. Traffic 4: 694-709.
  188. Walker, S.A, Cullen, P.J., Taylor, J.A., Lockyer, P.J. (2003) Control of Ras cycling by Ca2+. FEBS Lett. 546: 6-10.
  189. Varadi, A., Tsuboi, T., Johnson-Cadwell, L.I., Allan, V.J. & Rutter, G.A. (2003) Kinesin I and cytoplasmic dynein orchestrate glucose-stimulated insulin- containing vesicle movements in clonal MIN6 beta-cells. Biochem. Biophys. Res. Commun. 311: 272-82.
  190. Al-Shanti, N.A., Steward, C.G. & Garland, R.J. (2003) Optimization of functional efficacy of phosphorothioate-modified oligonucleotides in a human CD8+ T-cell ex vivo expansion model. Scand. J. Immunol. 58: 462-70.
  191. Tsuboi, T., DaSilva Xavier, G., Leclerc, I. & Rutter, GA. (2003) 5' AMP-activated protein kinase controls insulin-containing secretory vesicle dynamics. J Biol Chem. 278: 52042-51.
  192. De Bree, F.M., Van Der Kleij, A.A., Nijenhuis, M., Zalm, R., Murphy, D. & Burbach, J.P. (2003) The hormone domain of the vasopressin prohormone is required for the correct prohormone trafficking through the secretory pathway. J Neuroendocrinol. 15: 1156-63.
  193. Banerjee, S., Figueiredo, F.C., Easty, D.L., Dick, A.D. & Nicholls, S.M. (2003) Development of organised conjunctival leucocyte aggregates after corneal transplantation in rats. Br. J. Ophthalmol. 87: 1515-22.
  194. Crosby, D. & Poole, A.W. (2003) Physical and functional interaction between protein kinase C delta and Fyn tyrosine kinase in human platelets. J. Biol. Chem. 278: 24533-41.
  195. Bailey, C.P., Couch, D., Johnson, E., Griffiths, K., Kelly, E. & Henderson, G. (2003) m-Opioid receptor desensitization in mature rat neurons: lack of interaction between DAMGO and morphine. J. Neurosci. 23: 10515-20.
  196. Hughes, E.H., Schlichtenbrede, F.C., Murphy, C.C., Sarra, G.M., Luthert, P.J., Ali, R.R. & Dick, A.D. (2003) Generation of activated sialoadhesin-positive microglia during retinal degeneration. Invest. Ophthalmol. Vis. Sci. 44: 2229-34.
  197. Mayer, E.J., Hughes, E.H., Carter, D.A. & Dick, A.D. (2003) Nestin positive cells in adult human retina and in epiretinal membranes. Br. J. Ophthalmol. 87: 1154-8.
  198. Waki, H., Kasparov, S., Katahira, K., Shimizu, T., Murphy, D. & Paton, J.F.R. (2003) Dynamic exercise attenuates spontaneous baroreceptor reflex sensitivity in conscious rats. Exp. Physiol. 88: 517-26.
  199. Bienemann, A.S., Martin-Rendon, E., Cosgrave, A.S., Glover, C.P., Wong, L.F., Kingsman, S.M., Mitrophanous, K.A., Mazarakis, N.D. & Uney, J.B. (2003) Long-term replacement of a mutated nonfunctional CNS gene: reversal of hypothalamic diabetes insipidus using an EIAV-based lentiviral vector expressing arginine vasopressin. Mol. Ther. 7: 588-96.

    200. back to top


    2004 Publications

  200. DaSilvaXavier, G., Qian, Q., Cullen, P.J. & Rutter, G.A. (2004) Distinct roles for insulin and insulin-like growth factor-1 receptors in pancreatic beta-cell glucose sensing revealed by RNA silencing. Biochem. J. 377: 149-58.
  201. Venkateswarlu, K., Brandom, K.G. & Lawrence, J.L (2004). Centaurin-a1 is an in vivo PIP3-dependent GAP for ARF6 that is involved in actin cytoskeleton organization. J. Biol. Chem. 279(8): 6205-8.
  202. Guilleman, G., DaSilvaXavier, G., Rafiq, I., Leturque, A., & Rutter, G.A. (2004) Importin beta1 mediates the glucose-stimulated nuclear import of pancreatic and duodenal homeobox-1 in pancreatic islet beta-cells (MIN6). Biochem. J. 378: 219-27.
  203. Calderwood, M.A., Hall, K. T., Matthews, D. A. & Whitehouse, A. (2004). The Herpesvirus Saimiri ORF73 gene product interacts with host cell mitotic chromosomes and self associates via its C-terminus. J. Gen. Virol. 85: 147-153.
  204. Tsuboi, T., Lippiat, J.D., Ashcroft, F.M. & Rutter, G.A. (2004) ATP-dependent interaction of the cytosolic domains of the inwardly rectifying K+ channel Kir6.2 revealed by fluorescence resonance energy transfer. Proc. Natl. Acad. Sci. U S A 101: 76-81.
  205. Diraison, F., Parton, L., Ferre, P., Foufelle, F., Briscoe, C.P., Leclerc, I. & Rutter, G.A. (2004) Over-expression of sterol regulatory element binding protein-1c in rat pancreatic islets induces lipogenesis and decreases glucose-stimulated insulin release: modulation by 5-aminoimidazole-4-carboxamide ribonucleoside. Biochem. J. 378: 769-78.
  206. Harris, S.L., Cho, K., Bashir, Z.I. & Molnar, E. (2004) Metabotropic glutamate receptor signalling in perirhinal cortical neurons. Mol. Cell. Neurosci. 25: 275-87.
  207. Kanumilli, S., Toms, N.J. & Roberts, P.J. (2004) Novel metabotropic glutamate receptor negatively coupled to adenylyl cyclase in cultured rat cerebellar astrocytes. Glia 46: 1-7.
  208. Leclerc, I., Woltersdorf, W.W., Da Silva Xavier, G., Rowe, R.L., Cross, S.E., Korbutt, G.S., Rajotte, R.V., Smith, R. & Rutter, G.A. (2004) Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion. Am. J. Physiol. Endocrinol. Metab. 286: E1023-31.
  209. Pula, G., Mundell, S.J., Roberts, P.J. & Kelly, E. (2004) Agonist-independent internalization of metabotropic glutamate receptor 1a is arrestin- and clathrin- dependent and is suppressed by receptor inverse agonists. J. Neurochem. 89: 1009-20.
  210. Mundell, S.J., Pula, G., More, J., Jane, D., Roberts, P.J. & Kelly, E. (2004) Activation of cyclic AMP-dependent protein kinase inhibits the desensitization and internalization of metabotropic glutamate receptors 1a and 1b. Mol. Pharmacol. 65: 1507-16.
  211. Walker, S.A., Kupzig, S., Bouyoucef, D., Davies, L.C., Tsuboi, T., Bivona, T.G., Cozier, G.E., Lockyer, P.J., Buckler, A., Rutter, G.A., Allen, M.J., Philips, M.R. & Cullen, P.J. (2004) Identification of a Ras GTPase-activating protein regulated by receptor-mediated Ca2+ oscillations. EMBO J. 23: 1749-60.
  212. Stephens, D.J. & Pepperkok, R. (2004) Differential requirements for efficient GTP hydrolysis by Sar1p direct selective export of cargo from the endoplasmic reticulum. J. Cell Sci. 117: 3635-44.
  213. Hughes, E.H., Schlichtenbrede, F.C., Murphy, C.C., Broderick, C., Van Rooijen, N., Ali, R.R. & Dick, A.D. (2004) Minocycline delays photoreceptor death in the rds mouse through a microglia-independent mechanism. Exp. Eye Res. 78: 1077-84.
  214. Toye, A.M., Banting, G. & Tanner, M.J. (2004) Regions of human kidney anion exchanger 1 (kAE1) required for basolateral targeting of kAE1 in polarised kidney cells: mis-targeting explains dominant renal tubular acidosis (dRTA). J. Cell Sci. 117:1399-410.
  215. Parton, L.E., Diraison, F., Neill, S.E., Ghosh, S.K., Rubino, M.A., Bisi, J.E., Briscoe, C.P. & Rutter, G.A. (2004) Impact of PPARg over-expression and activation on pancreatic islet gene expression profile analysed with oligonucleotide microarrays. Am. J. Physiol. Endocrinol. Metab. 287: E390-404.
  216. Luyt, K, Varadi, A., Halfpenny, C.A., Scolding, N.J. & Molnar, E (2004) Metabotropic glutamate receptors are expressed in adult human glial progenitor cells Biochem. Biopys. Res. Commun. 319: 120-9.
  217. Da Silva Xavier, G., Rutter, J. & Rutter, G.A. (2004) Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose. Proc. Natl. Acad. Sci. U.S.A. 101: 8319-24.
  218. Ashby, M.C., De La Rue, S.A., Ralph, G.S., Uney, J., Collingridge, G.L. & Henley, J.M. (2004) Removal of AMPA receptors (AMPARs) from synapses is preceded by transient endocytosis of extrasynaptic AMPARs. J Neurosci. 24: 5172-6.
  219. Swingler, T.E., Bess, K.L., Yao, J., Stifani, S. & Jayaraman, P.S. (2004) The proline-rich homeodomain (PRH) protein recruits members of the groucho/TLE protein family to co-repress transcription in haematopoietic cells. J. Biol. Chem. 279: 34938-47.
  220. Varadi, A. & Rutter, G.A. (2004) Ca2+-induced Ca2+ release in pancreatic islet b-cells: critical evaluation of the use of ER-targeted "Cameleons" Endocrinology 145: 4540-9.
  221. Barber, S.C., Mellor, H., Gampel, A., & Scolding, N.J. (2004) S1P and LPA trigger Schwann cell actin changes and migration. Eur J Neurosci. 19: 3142-50.
  222. Wherlock, M., Gampel, A., Futter, C. & Mellor, H. (2004) Farnesyltransferase inhibitors disrupt EGF receptor traffic through modulation of the RhoB GTPase. J. Cell. Sci. 117: 3221-31.
  223. Wang, W.Y., Whittles, C.E., Harper, S.J. & Bates, D.O. (2004) An adenovirus- mediated gene-transfer model of angiogenesis in rat mesentery. Microcirculation 11: 361-75.
  224. Varadi, A., Johnson-Cadwell, L.I., Cirulli, V., Yoon, Y., Allan, V.J. & Rutter, G.A. (2004) Cytoplasmic dynein regulates the subcellular distribution of mitochondria by controlling the recruitment of the fission factor dynamin-related protein-1. J. Cell Sci.117: 4389-400.
  225. Correa, S.A., Munton, R., Nishimune, A., Fitzjohn, S. & Henley, J.M. (2004) Development of GABA(B) subunits and functional GABA(B) receptors in rat cultured hippocampal neurons. Neuropharmacology 47: 475-84.
  226. Kasparov, S., Teschemacher, A.G., Hwang, D.-Y., Kim, K.-S, Lonergan, T. & Paton, J.F.R. (2004) Viral vectors as tools for studies of central cardiovascular control. Prog. Biophys. Mol. Biol. 84: 251-77.
  227. Hearn, A.R., De Haan, L., Pemberton, A.J., Hirst, T.R. & Rivett, A.J. (2004) Trafficking of exogenous peptides into proteasome--dependent Major Histocompatability Complex class I pathway following enterotoxin B subunit-mediated delivery. J. Biol. Chem. 279: 51315-22.
  228. La Ragione, R.M., Best, A., Sprigings, K.A., Cooley, W.A., Jepson, M.A. & Woodward, M.J. (2004) Interaction between attaching and effacing Escherichia coli serotypes O157:H7 and O26:K60 in cell culture. Vet. Microbiol. 104: 119-24.
  229. Dean, P. & Kenny, B. (2004) Intestinal barrier dysfunction by enteropathogenic Escherichia coli is mediated by two effector molecules and a bacterial surface protein. Mol. Microbiol. 54: 665-75.
  230. Varadi, A., Cirulli, V. & Rutter, G.A. (2004) Mitochondrial localization as a determinant of capacitative Ca(2+) entry in HeLa cells. Cell Calcium 36: 499-508.
  231. Caunt, C.J., Hislop, J.N., Kelly, E., Matharu, A.L., Green, L.D., Sedgley, K.R., Finch, A.R. & McArdle, C.A. (2004) Regulation of gonadotropin-releasing hormone receptors by protein kinase C: inside out signalling and evidence for multiple active conformations. Endocrinology 145: 3594-602.
  232. Roeder, G.E., Parish, J.L., Stern, P.L. & Gaston, K. (2004) Herpes simplex virus VP22-human papillomavirus E2 fusion proteins produced in mammalian or bacterial cells enter mammalian cells and induce apoptotic cell death. Biotechnol. Appl. Biochem. 40: 157-65.
  233. Passey, S., Pellegrin, S. & Mellor, H. (2004) What is in a filopodium? Starfish versus hedgehogs. Biochem. Soc. Trans. 32: 1115-7.
  234. Jones, M.L., Craik, J.D., Gibbins, J.M. & Poole, A.W. (2004) Regulation of SHP-1 tyrosine phosphatase in human platelets by serine phosphorylation at its C-terminus. J. Biol. Chem. 279, 40475-83.
  235. Lawoko-Kerali, G., Helyer, R., Milo, M., Davies, D., Halsall, A., Johnson, C.M., Kros ,C.J., Tones, M.A., Rivolta, M.N. & Holley, M.C. (2004) Ventral otic cell lines as developmental models of auditory epithelial and neural precursors. Dev. Dynam. 231: 801-14.
  236. Woolard, J., Wang, W.Y., Bevan, H.S., Qiu, Y., Morbidelli, L., Pritchard-Jones, R.O., Cui, T., Sugiono, M., Waine, E., Perrin, R., Digby-Bell, J., Shields, J.D., Whittles, C.E., Mushens, R.E., Gillat, D.A., Ziche, M., Harper, S.J. & Bates, D.O. (2004) VEGF165b, an inhibitory vascular endothelial growth factor splice variant: mechanism of action, in vivo effect on angiogenesis and endogenous protein expression. Cancer Res. 64: 7822-35.
  237. Berwick, D.C., Dell, G.C., Welsh, G.I., Heesom, K.J., Hers, I., Fletcher, L.M., Cooke, F.T. & Tavaré, J.M. (2004) Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles. J. Cell Sci. 117: 5985-93.
  238. Carlton, J., Bujny, M., Peter, B.J., Oorschot, V.M., Rutherford, A. & Mellor, H., Klumperman, J., McMahon, H.T. & Cullen, P.J. (2004) Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high-curvature membranes and 3-Phosphoinositides. Curr. Biol. 14: 1791-800.
  239. Welsh, G.I., Griffiths, M.R, Webster, K.J., Page, M. & Tavaré, J.M. (2004) Proteome analysis of adipogenesis. Proteomics 4: 1042-1051.

    240. back to top


    2005 Publications

  240. Watson, P., Forster, R., Palmer, K.J., Pepperkok, R. & Stephens, D.J. (2005) Coupling of ER exit to microtubules through direct interaction of COPII with dynactin. Nat. Cell Biol. 7: 48-55.
  241. Buda, A., Sands, C. & Jepson, M.A. (2005) Use of fluorescence imaging to investigate the structure and function of intestinal M cells. Adv. Drug Deliv. Rev. 57: 123-34.
  242. Watson, P., Jones, A.T. & Stephens, D.J. (2005) Intracellular traffickingpathways and drug delivery: Fluorescence imaging of living and fixed cells. Adv. Drug Deliv. Rev. 57: 43-61.
  243. Murillo, I. & Henderson, L.M. (2005) Expression of gp91(phox)/Nox2 in COS-7 cells: cellular localization of the protein and the detection of outward proton currents. Biochem. J. 385: 649-57.
  244. Pellegrin, S. & Mellor, H. (2005) The Rho Family GTPase Rif Induces Filopodia through mDia2. Curr. Biol. 15: 129-33.
  245. Curnow, P., Mellor, H., Stephens, D.J., Lorch, M. & Booth, P.J. (2005) Translocation of the cell-penetrating Tat peptide across artificial bilayers and into living cells. Biochem. Soc. Symp. 72: 199-209.
  246. Pula, G., Crosby, D., Baker, J., Poole, A.W. (2005) Functional interaction of PKCa with the tyrosine kinases Syk and Src in human platelets. J. Biol. Chem. 280: 7194-205.
  247. Barnes, J.D., Arhel, N.J., Lee, S-S., Sharp, A., Al-Okail, M., Packham, G., Hague, A., Paraskeva, C. & Williams, A.C. (2005) Nuclear Bag-1 protects against radiation induced apoptosis in colorectal adenoma derived epithelial cells. Apoptosis 10: 301-11.
  248. Lee, Y.B., Cosgrave, A.S., Glover, C.P., Bienemann, A., Heywood, D., Hobson, R.J. & Uney, J.B. (2005) Increased utility in the CNS of a powerful neuron-specific tetracycline-regulatable adenoviral system developed using a post-transcriptional enhancer. J. Gene Med. 7: 576-83.
  249. Toye, A.M., Ghosh, S., Young, M.T., Jones, G.K., Sessions, R.B., Ramaugé, M., Leclerc, P., Basu, J., Delaunay, J. & Tanner, M.J.A. (2005) Protein 4.2 association with band 3 (AE1, SLCA4) in Xenopus oocytes: effects of three natural protein 4.2 mutations associated with hemolytic anemia. Blood 105: 4088-95.
  250. Henry, B.A., Lightman, S.L. & Lowry, C.A. (2005) Distribution of corticotropin- releasing factor binding protein-immunoreactivity in the rat hypothalamus: association with corticotropin-releasing factor-, urocortin 1- and vimentin-immunoreactive fibres. J. Neuroendocrinol. 17: 135-144.
  251. Hirbec, H., Martin, S. & Henley, J.M. (2005) Syntenin is involved in the developmental regulation of neuronal membrane architecture. Mol. Cell. Neurosci..28: 737-746.
  252. Stramer, B., Wood, W., Galko, M.J., Redd, M.J., Jacinto, A., Parkhurst, S.M. & Martin, P. (2005) Live imaging of wound inflammation in Drosophila embryos reveals key roles for small GTPases during in vivo cell migration. J. Cell Biol. 168: 567-73.
  253. Lawrence, J., Mundell, S.J., Yun, H., Kelly, E. & Venkateswarlu, K. (2004) Centaurin-a1, an ADP-Ribosylation Factor 6 GTPase Activating Protein, Inhibits 2-Adrenoceptor Internalization. Mol. Pharmacol. 67: 1822-8.
  254. Varadi, A., Tsuboi, T. & Rutter, G.A. (2005) Myosin Va transports dense core secretory vesicles in pancreatic MIN6 b-cells. Mol. Biol. Cell 16: 2670-80.
  255. Tsuboi, T., Ravier, M.A., Xie, H., Ewart, M.A., Gould, G.W., Baldwin, S.A. & Rutter, G.A. (2005) Mammalian exocyst complex is required for the docking step of insulin vesicle exocytosis. J. Biol. Chem. 280: 25565-70.
  256. Bannister, N.J., Benke, T.A., Mellor, J., Scott, H., Gurdal, E., Crabtree, J.W. & Isaac, J.T. (2005) Developmental changes in AMPA and kainate receptor-mediated quantal transmission at thalamocortical synapses in the barrel cortex. J. Neurosci. 25: 5259-71.
  257. Wilson, M.C., Meredith, D., Manning Fox, J.E., Manoharan, C., Davies, A.J. & Halestrap, A.P. (2005) Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is embigin (gp70). J. Biol. Chem. 280: 27213-21.
  258. Ravier, M.A. & Rutter, G.A. (2005) Glucose or insulin, but not zinc ions, inhibit glucagon secretion from mouse pancreatic a-cells. Diabetes 54: 1789-97.
  259. Venkateswarlu, K., Hanada, T. & Chishti, A.H. (2005) Centaurin-a1 interacts directly with kinesin motor protein KIF13B. J. Cell Sci.18: 2471-84.
  260. Clemo, N.K., Arhel, N.J., Barnes, J.D., Baker, J., Moorghen, M., Packham, G.K., Paraskeva, C. & Williams, A.C. (2005) The role of the retinoblastoma protein (Rb) in the nuclear localization of BAG-1: implications for colorectal tumour cell survival. Biochem. Soc. Trans. 33: 676-8.
  261. Robinson, E.S., Nutt, D.J., Jackson, H.C. & Hudson, A.L. (2005) The uptake of a fluorescently labelled antisense oligonucleotide in vitro and in vivo. J Neurosci Methods. 147: 48-54.
  262. Lane, J.D., Woodman, P.G. & Allan, V.J. (2005) Active relocation of chromatin and endoplasmic reticulum into blebs in late apoptotic cells. J. Cell Sci. 118: 4059-71.
  263. Palmer, C.L., Lim, W., Hastie, P., Toward, M., Korolchuk, V.I., Burbidge, S.A., Banting, G., Collingridge, G.L., Isaac, J.T.R. & Henley, J.M. (2005) Hippocalcin functions as a calcium sensor in hippocampal LTD. Neuron 47: 487-94.
  264. Hislop, J.N., Caunt, C.J., Sedgley, K.R., Kelly, E., Mundell, S., Green, L.D. & McArdle, C.A. (2005) Internalization of gonadotropin-releasing hormone receptors (GnRHRs): does arrestin binding to the C-terminal tail target GnRHRs for dynamin-dependent internalization? J. Mol. Endocrinol.35: 177-89.
  265. Palmer, K.J., Konkel, J.E. & Stephens, D.J. (2005) PCTAIRE protein kinases interact directly with the COPII complex and modulate secretory cargo transport. J. Cell Sci. 118: 3839-47.
  266. Bouschet, T., Martin, S. & Henley, J.M. (2005) Receptor activity modifying proteins (RAMPs) are required for forward trafficking of the Calcium Sensing Receptor (CaSR) to the plasma membrane. J. Cell Sci. 118: 4709-20.
  267. Brayden, D.J., Jepson, M.A. & Baird, A.W. (2005) Intestinal Peyer's patch M cells and oral vaccine targeting. Drug Discov. Today 10: 1145-57.
  268. Pula, G., Mundell, S.J., Roberts, P.J. & Kelly, E. (2005) Analysis of mGluR1a constitutive internalization using a pulse-chase enzyme-linked immuno-sorbant assay (ELISA). J. Biochem. Biophys. Methods 64: 167-81.
  269. Carlton, J., Bujny, M.V., Peter, B.J., Oorschot, V.M.J., Rutherford, A. Arkell, R.S., Klumperman, J., McMahon, H.T. & Cullen, P.J. (2005) Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport. J. Cell Sci. 118: 4527-39.
  270. Gunn-Moore, F.J., Welsh, G.I., Herron, L.R., Brannigan F., Venkateswarlu, K., Gillespie, S. Brandwein-Gensler, M., Madan, R., Tavaré, J.M., Brophy, P.J., Prystowsky, M.B. & Guild, S. (2005) A novel 4.1 ezrin radixin moesin (FERM) containing protein, 'Willin' FEBS Lett. 579: 5089-5094.
  271. Coward, R.J., Welsh, G.I., Yang, J., Tasman, C., Lennon, R., Koziell, A., Satchell, S., Holman, G.D., Kerjaschki, D., Tavaré, J.M., Mathieson, P.W. & Saleem, M.A. (2005) The human glomerular podocyte is a novel target for insulin-action. Diabetes 54: 3095-3102.
  272. Duale, H., Kasparov, S., Paton, J. F.R, & Teschemacher, A. G. (2005) Differences in transductional tropism of adenoviral and lentiviral vectors in the rat brainstem. Exp. Physiol. 90: 71-8.
  273. Richards, S.K., Parton, L.E., Leclerc, I., Rutter, G.A. & Smith, R.M. (2005) Over-expression of AMP-activated protein kinase impairs pancreatic b-cell function in vivo. J. Endocrinol. 187: 225-35.
  274. Castino, R., Davies, J., Beaucourt, S., Isidoro, C. & Murphy, D. (2005) Autophagy is a pro-survival mechanism in cells expressing an autosomal dominant familial neurohypophyseal diabetes insipidus mutant vasopressin transgene. FASEB J 19: 1021-3 .
  275. Castino, R., Isidoro, C. & Murphy, D. (2005) Autophagy-dependent cell survival and cell death in an autosomal dominant familial neurohypophyseal diabetes insipidus in vitro model. FASEB J. 19: 1024-6.
  276. Bilang-Bleuel, A., Ulbricht, S., Chandramohan, Y., De Carli, S., Droste, S.K. & Reul, J.M.H.M. (2005) Psychological stress increases histone H3 phosphorylation in adult dentate gyrus granule neurons: involvement in a glucocorticoid receptor-dependent behavioural response. Eur. J. Neurosci. 22: 1691-1700.

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    2006 Publications

  277. Smith, M.P., Ayad, V.J., Mundell, S.J., McArdle, C.A., Kelly, E. & Lopez, B.A. (2006) Internalization and desensitization of the oxytocin receptor is inhibited by dynamin and clathrin mutants in HEK-293 cells. Mol. Endocrinol. 20: 379-88.
  278. Bright, J., Desikan, R., Hancock, J.T., Weir, I.S., Neill, S.J. (2006) ABA-induced NO generation and stomatal closure in Arabidopsis are dependent on H2O2 synthesis. Plant J. 45: 113-22.
  279. Caunt, C.J., Finch, A.R., Sedgley, K.R., Oakely, L., Luttrell, L.M. & McArdle, C.A. (2006) Arrestin-mediated ERK activation by gonadotropin-releasing hormone receptors (GnRHRs): Receptor-specific activation mechanisms and compartmentalization. J. Biol. Chem. 281: 2701-10.
  280. Dean, P., Maresca ,M., Schuller, S., Phillips, A.D. & Kenny, B. (2006) Potent diarrheagenic mechanism mediated by the cooperative action of three enteropathogenic Escherichia coli-injected effector proteins. Proc. Natl. Acad. Sci. U S A. 103: 1876-81.
  281. Wentworth, J.K., Pula, G. & Poole, A.W. (2006) Vasodilator-stimulated phosphoprotein (VASP) is phosphorylated on Ser157 by protein kinase C-dependent and -independent mechanisms in thrombin-stimulated human platelets. Biochem J. 393: 555-64.
  282. Tsuboi, T., Ravier, M.A., Parton, L.E. & Rutter, G.A. (2006) Sustained exposure to high glucose concentrations modifies glucose signaling and the mechanics of secretory vesicle fusion in primary rat pancreatic b-cells. Diabetes 55: 1057-65.
  283. Benest, A.V., Salmon, A.H., Wang, W., Glover, C.P., Uney, J., Harper, S.J. & Bates, D.O. (2006) VEGF and angiopoietin-1 stimulate different angiogenic phenotypes that combine to enhance functional neovascularization in adult tissue. Microcirculation 13: 423-37.
  284. Parish, J.L., Kowalczyk, A., Chen, H.T., Roeder, G.E., Sessions, R., Buckle, M., Gaston, K. (2006) E2 proteins from high- and low-risk human papillomavirus types differ in their ability to bind p53 and induce apoptotic cell death. J. Virol. 80: 4580-90.
  285. Johnson, E.A., Oldfield, S., Braksator, E., Gonzalez-Cuello, A., Hall, K.J., Couch, D., Mundell, S.J., Bailey, C.P., Kelly, E. & Henderson, G. (2006) Agonist-selective mechanisms of {micro}-opioid receptor (MOR) desensitization in HEK293 cells. Mol. Pharmacol. 70: 676-85.
  286. Varadi A, Grant A, McCormack M, Nicolson T, Magistri M, Mitchell KJ, Halestrap AP, Yuan H, Schwappach B, Rutter GA. (2006) Intracellular ATP-sensitive K(+) channels in mouse pancreatic beta cells: against a role in organelle cation homeostasis. Diabetologia. 49: 1567-77.
  287. Lawrence, F.J., McStay, B. & Matthews, DA. (2006) Nucleolar protein upstream binding factor is sequestered into adenovirus DNA replication centres during infection without affecting RNA polymerase I location or ablating rRNA synthesis. J Cell Sci. 119: 2621-31.
  288. Moss, D.K., Betin, V.M., Malesinski, S.D. & Lane, J.D. (2006) A novel role for microtubules in apoptotic chromatin dynamics and cellular fragmentation. J. Cell. Sci. 119: 2362-74.
  289. Soufi, A., Smith, C., Clarke, A.R., Gaston, K. & Jayaraman, P.S. (2006) Oligomerisation of the developmental regulator proline rich homeodomain (PRH/Hex)is mediated by a novel proline-rich dimerisation domain. J. Mol. Biol. 358: 943-62.
  290. Moss, D.K., Lane, J.D. (2006) Microtubules: forgotten players in the apoptotic execution phase. Trends Cell Biol. 16: 330-8.
  291. Watson, P., & Stephens, D.J. (2006) Microtubule plus-end loading of p150(Glued) is mediated by EB1 and CLIP-170 but is not required for intracellular membrane traffic in mammalian cells. J. Cell Sci. 119: 2758-67.
  292. Wong, C.K., Lai, T., Holly, J.M., Wheeler, M.H., Stewart, C.E. & Farndon, J.R. (2006) Insulin-like growth factors (IGF) I and II utilize different calcium signaling pathways in a primary human parathyroid cell culture model. World J. Surg.. 30: 333-45.
  293. Gampel, A., Moss, L., Jones, M.C., Brunton, V., Norman, J.C. & Mellor, H. (2006) VEGF regulates the mobilisation of VEGFR-2/KDR from an intracellular endothelial storage compartment. Blood. 108: 2624-31.
  294. Toye AM, Parker MD, Daly CM, Lu J, Virkki LV, Pelletier MF, Boron WF. (2006) The human nbce1-a mutant r881c, associated with proximal renal tubular acidosis, retains function but is mistargeted in polarized renal epithelia. Am. J. Physiol. Cell. Physiol. 291: C788-801.
  295. Bell, C.J., Bright, N.A., Rutter, G.A. & Griffiths, E.J. (2006) ATP regulation in adult rat cardiomyocytes: Time resolved decoding of rapid mitochondrial calcium spiking imaged with targeted photoproteins. J. Biol. Chem. 281: 28058-67.
  296. Luyt, K., Varadi, A., Durant, C.F. & Molnar, E. (2006) Oligodendroglial metabotropic glutamate receptors are developmentally regulated and involved in the prevention of apoptosis J. Neurochem. 99: 641-56.
  297. Mundell, S.J., Luo, J., Benovic, J.L., Conley, P.B. & Poole, A.W. (2006) Distinct clathrin-coated pits sort different G protein-coupled receptor cargo. Traffic 7: 1420-31.
  298. da Silva Xavier, G., Rutter, G.A., Diraison, F., Andreolas, C. & Leclerc, I. (2006) Carbohydrate responsive-element binding protein (chREBP) binding to fatty acid synthase and L-type pyruvate kinase genes is stimulated by glucose in pancreatic MIN6 beta -cells. J. Lipid Res. 47: 2482-91.
  299. Caunt, C.J., Finch, A.R., Sedgley, K.R. & McArdle CA. (2006) GnRH receptor signalling to ERK: kinetics and compartmentalization. Trends Endocrinol. Metab. 17(8):308-13.
  300. Watson, P., Townley, A.K., Koka, P., Palmer, K.J. & Stephens, D.J. (2006) Sec16 defines ER exit sites and is required for secretory cargo export in mammalian cells. Traffic, 7: 1678-87 .
  301. Pula, G., Schuh, K., Nakayama, K., Nakayama, K.I., Walter, U. & Poole, A.W. (2006) PKC-d regulates collagen-induced platelet aggregation through inhibition of VASP-mediated filopodia formation. Blood 108: 4035-44.
  302. Hill, A.J., Hinton ,J.M., Cheng, H., Gao, Z., Bates, D.O., Hancox, J.C., Langton, P.D. & James, A.F. (2006) A TRPC-like non-selective cation current activated by alpha 1-adrenoceptors in rat mesenteric artery smooth muscle cells. Cell Calcium. 40: 29-40
  303. An, R., da Silva Xavier, G., Hao, H.X., Semplici, F., Rutter, J. & Rutter, G.A. (2006) Regulation by Per-Arnt-Sim (PAS) kinase of pancreatic duodenal homeobox-1 nuclear import in pancreatic beta-cells. Biochem. Soc. Trans. 34: 791-3.
  304. Liu, B.H., Yang, Y., Paton, J. F. R., Li, F., Boulaire, J., Kasparov, S. & Wang, S. (2006). GAL4-NFkappaB fusion protein augments transgene expression from neuronal promoters in the rat brain. Mol. Therapy 14: 872-82.
  305. Manoharan, C., Wilson, M.C., Sessions, R.B. & Halestrap, A.P. (2006) The role of charged residues in the transmembrane helices of monocarboxylate transporter 1 and its ancillary protein basigin in determining plasma membrane expression and catalytic activity. Mol. Membr. Biol. 23: 486-98.
  306. Lartey, J., Gampel, A., Pawade, J., Mellor, H. & Bernal, A.L. (2006) Expression of RND proteins in human myometrium. Biol. Reprod. 75: 452-61
  307. McInnis, S.M., Desikan, R., Hancock, J.T. & Hiscock, S.J. (2006) Production of reactive oxygen species and reactive nitrogen species by angiosperm stigmas and pollen: potential signalling crosstalk. New Phytologist 172: 221-8.
  308. McInnis, S.M., Emery, D.C., Porter, R., Desikan, R., Hancock, J.T. & Hiscock, S.J. (2006) The role of stigma peroxidises in flowering plants: insights from further characterization of a stigma-specific peroxidise (SSP) from Senecio squalidus (Asteraceae). J. Exp. Bot. 57: 1835-46.
  309. Waki, H., Murphy, D., Yao, S.T., Kasparov, S. & Paton, J.F.R. (2006) Endothelial nitric oxide synthase in the nucleus tractus solitarii contributes to the hypertension in the spontaneously hypertensive rat. Hypertension 48: 644-50.
  310. Sedgley, K.R., Finch, A.R., Caunt, C.J. & McArdle, C.A. (2006) Intracellular gonadotropin-releasing hormone receptors in breast cancer and gonadotrope lineage cells. J. Endocrinol. 191: 625-36.
  311. Rutherford, A.C., Traer, C., Wassmer, T., Pattni, K., Bujny, M.V., Carlton, J.G., Stenmark, H. & Cullen, P.J. (2006) The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport. J. Cell Sci. 119: 3944-57.
  312. Chell, S.D., Witherden, I.R., Dobson, R.R., Moorghen, M., Herman, A., Qualtrough, D., Williams, A.C. & Paraskeva, C. (2006) Increased EP4 receptor expression in colorectal cancer progression promotes cell growth and anchorage independence. Cancer Res, 66,: 3106-13.
  313. Kaidi, A., Qualtrough, D., Williams, A.C., & Paraskeva, C. (2006). Direct transcriptional upregulation of COX-2 by HIF-1 promotes tumour cell survival and enhances HIF-1 transcriptional activity during hypoxia. Cancer Res. 66: 6683-6691.

    314. back to top


    2007 Publications

  314. McKinnon, C.M., Ravier, M.A. & Rutter, G.A. (2007) FoxO1 is required for the regulation of preproglucagon gene expression by insulin in pancreatic alpha -(TC1-9) cells. J. Biol. Chem. 281: 39358-69.
  315. Nobbs, A.H., Shearer, B.H., Drobni, M., Jepson, M.A. & Jenkinson, H.F. (2007) Adherence and internalization of Streptococcus gordonii by epithelial cells involves b1 integrin recognition by SspA and SspB (Antigen I/II family) polypeptides. Cell. Microbiol. 9: 65-83.
  316. Rowe, H.A., Griffiths, N.J., Hill, D.J. & Virji, M. (2007) Co-ordinate action of bacterial adhesins and human carcinoembryonic antigen receptors in enhanced cellular invasion by capsulate serum resistant Neisseria meningitidis. Cell. Microbiol. 9: 154-168.
  317. Mountjoy, P.D., Bailey, S.J. & Rutter, G.A. (2007) Inhibition by glucose or leptin of hypothalamic neurons expressing neuropeptide Y requires changes in AMP-activated protein kinase activity. Diabetologia. 50: 168-77.
  318. Wassmer, T., Attar, N., Bujny, M.V., Oakley, J., Traer, C.J. & Cullen, P.J. (2007) A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer. J. Cell Sci. 120: 45-54.
  319. Bailey SJ, Ravier MA, Rutter GA. (2007) Glucose-dependent regulation of g-aminobutyric acid (GABAA) receptor expression in mouse pancreatic islet a-cells. Diabetes. 56: 320-7.
  320. Evans, I.R., Renne, T., Gertler, F.B. & Nobes, C.D. (2007) Ena/VASP proteins mediate repulsion from ephrin ligands. J. Cell Sci. 120: 289-298.
  321. Kaidi, A., Williams, A.C. & Paraskeva, C. (2007) Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia. Nat. Cell Biol. 9: 210-17.
  322. Venkateswarlu, K., Brandom, K.G. & Yun, H. (2007) PI-3-kinase-dependent membrane recruitment of centaurin-{alpha}2 is essential for its effect on ARF6-mediated actin cytoskeleton reorganisation. J. Cell Sci. 120: 792-801.
  323. Mountjoy, P.D. & Rutter, G.A. (2007) Glucose sensing by hypothalamic neurons and pancreatic islet cells: AMPle evidence for common mechanisms? Exp. Physiol. 92: 311-9.
  324. Williams, A.C., Smartt, H., H-Zadeh, A.M., Macfarlane, M., Paraskeva, C. & Collard, T.J. (2007). Insulin-like growth factor binding protein 3 (IGFBP-3) potentiates TRAIL-induced apoptosis of human colorectal carcinoma cells through inhibition of NF-kB. Cell Death Differ. 14: 137-45.
  325. Hiscock, S.J., Bright, J., McInnis, S.M., Desikan, R. & Hancock, J.T. (2007) Signaling on the stigma: potential new roles for ROS and NO in plant cell signalling. Plant Signal. Behav. 2: 23 - 24.
  326. Martinez-Argudo, I., Sands, C. & Jepson, M.A. (2007) Translocation of Enteropathogenic E. coli across an in vitro M cell model is regulated by its type III secretion system. Cell. Microbiol. 9: 1538-46.
  327. Lartey, J., Smith, M., Pawade, J., Strachan, B., Mellor, H. & Lopez Bernal, A. (2007) Up-regulation of myometrial Rho effector proteins (PKN1 and DIAPH1) and CPI-17 (PPP1R14A) phosphorylation in human pregnancy is associated with increased GTP-RhoA in spontaneous preterm labor. Biol. Reprod.. 76: 971-82.
  328. Waki, H., Liu, B., Miyake, M., Katahira, K. & Murphy, D., Kasparov, S. & Paton, J.F. (2007) Junctional adhesion molecule-1 is upregulated in spontaneously hypertensive rats. Evidence for a prohypertensive role within the brain stem. Hypertension 49: 1321-7.
  329. Davies, D. (2007) Temporal and spatial regulation of a6 integrin expression during the development of the cochlear-vestibular ganglion. J. Comp. Neurol. 502: 673-682.
  330. Park, H., Varadi, A., Seok, H., Jo, J., Gilpin, H., Liew, C.G., Jung, S., Andrews, P.W., Molnar, E. & Cho, K. (2007) mGluR5 is involved in dendrite differentiation and excitatory synaptic transmission in NTERA2 human embryonic carcinoma cell-derived neurons. Neuropharmacol. 52: 1403-14.
  331. Groeger, G. & Nobes, C.D. (2007) Co-operative Cdc42 and Rho signalling mediates ephrinB-triggered endothelial cell retraction. Biochem. J. 404: 23-9.
  332. Bujny, M.V., Popoff, V., Johannes, L. & Cullen, P.J. (2007) The retromer component sorting nexin-1 is required for efficient retrograde transport of Shiga toxin from early endosome to the trans Golgi network. J. Cell Sci. 120: 2010-21.
  333. Baroukh, N., Ravier, M.A., Loder, M.K., Hill, E.V., Bounacer, A., Scharfmann, R., Rutter, G.A. & Van Obberghen, E. (2007) MicroRNA-124a regulates Foxa2 expression and intracellular signaling in pancreatic b-cells lines. J. Biol. Chem. 282(27): 19575-88.
  334. Gouraud, S.S., Heesom, K., Yao, S.T., Qiu, J., Paton, J.F. & Murphy, D. (2007) Dehydration-induced proteome changes in the rat hypothalamo-neurohypophyseal system. Endocrinology 148: 3041-52.
  335. Cogan, T.A., Thomas, A.O., Rees, L.E.N., Taylor, A.H., Jepson, M.A., Williams, P.H., Ketley, J. & Humphrey, T.J. (2007) Norepinephrine increases the pathogenic potential of Campylobacter jejuni. Gut 56: 1060-5.
  336. Lee, S.S., Crabb, S.J., Janghra, N., Carlberg, C., Williams, A.C., Cutress, R.I., Packham, G. & Hague, A. (2007) Subcellular localisation of BAG-1 and its regulation of vitamin D receptor-mediated transactivation and involucrin expression in oral keratinocytes: Implications for oral carcinogenesis. Exp. Cell Res. 313: 3222-38.
  337. Lee, Y.B., Colley, S., Norman, M., Biamonti, G. & Uney, J.B. (2007) SAFB re-distribution marks steps of the apoptotic process. Exp. Cell Res. 313: 3914-23.
  338. Perrett, C.A. & Jepson, M.A. (2007) Applications of cell imaging in Salmonella research Methods Mol Biol v394, Salmonella: Methods and protocols pp 235-273.
  339. Thirthagiri, E., Robinson, C.M., Huntley, S., Davies, M., Yap, L.F., Prime, S.S. & Paterson, I.C. (2007) Spindle assembly checkpoint and centrosome abnormalities in oral cancer. Cancer Lett. 258: 276-85.
  340. Chan, C.W., Lee, Y.B., Uney, J., Flynn, A., Tobias, J.H. & Norman, M. (2007) A novel member of the SAF (scaffold attachment factor)-box protein family inhibits gene expression and induces apoptosis. Biochem. J. 407: 355-62.
  341. Danson, C.M., Pocha, S.M., Bloomberg, G.B. & Cory, G.O. (2007) Phosphorylation of WAVE2 by MAP kinases regulates persistent cell migration and polarity. J. Cell Sci. 120: 4144-54.
  342. Hindley, C.E., Lawrence, F.J. & Matthews, D.A. (2007) A role for transportin in the nuclear import of adenovirus core proteins and DNA. Traffic 8: 1313-22.
  343. Hindley, C.E., Davidson, A.D. & Matthews, D.A. (2007) Relationship between adenovirus DNA replication proteins and nucleolar proteins B23.1 and B23.2. J. Gen. Virol. 88: 3244-8.
  344. Gouraud, S.S., Yao, S.T., Heesom, K.J., Paton, J.F. & Murphy, D. (2007) 14-3-3 proteins within the hypothalamic-neurohypophyseal system of the osmotically stressed rat: transcriptomic and proteomic studies. J. Neuroendocrinol. 19: 913-22.
  345. Rollason, R., Korolchuk, V., Hamilton, C., Schu, P. & Banting, G. (2007) Clathrin-mediated endocytosis of a lipid-raft-associated protein is mediated through a dual tyrosine motif. J Cell Sci. 120: 3850-8.
  346. Welsh, G.I., Leney, S.E., Lloyd-Lewis, B., Wherlock, M., Lindsay, A.J., McCaffrey, M.W. & Tavaré, J.M. (2007) Rip11 is a Rab11- and AS160-RabGAP-binding protein required for insulin-stimulated glucose uptake in adipocytes. J.Cell Sci. 120: 4197-208.

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    2008 Publications

  347. Traer, C.J., Rutherford, A.C., Palmer, K.J., Wassmer, T., Oakley, J., Carlton, J.G., Kremerskothen, J., Stephens, D.J. & Cullen, P.J. (2008). Sorting nexin-4 co-ordinates endosomal sorting of transferrin receptor with dynein-mediated transport into the endocytic recycling compartment. Nat. Cell Biol. 9: 1370-80.
  348. Riboulet-Chavey, A., Diraison, F., Siew, L.K., Wong, F.S. & Rutter, G.A. (2008) Inhibition of AMP-activated protein kinase protects pancreatic beta-cells from cytokine-mediated apoptosis and CD8+ T-cell-induced cytotoxicity. Diabetes 57: 415-23.
  349. Benest AV, Harper SJ, Herttuala SY, Alitalo K, Bates DO. (2008) VEGF-C induced angiogenesis preferentially occurs at a distance from lymphangiogenesis. Cardiovasc Res. 78: 315-23.
  350. Bienemann, A.S., Lee, Y.B., Howarth, J. & Uney, J.B. (2008) Hsp70 suppresses apoptosis in sympathetic neurones by preventing the activation of c-Jun. J. Neurochem. 104: 271-8.
  351. Toye, A.M., Williamson, R.C., Khanfar, M., Bader-Meunier, B., Cynober, T., Thibault, M., Tchernia, G., Dechaux, M,, Delaunay, J. & Bruce, L.J. (2008) Band 3 Courcouronnes (Ser667Phe): a trafficking mutant differentially rescued by wild type band 3 and glycophorin A. Blood 111: 5380-9.
  352. Mari, M., Bujny, M.V., Zeuschner, D., Geerts, W.J., Griffith, J., Petersen, C.M., Cullen, P.J., Klumperman, J. & Geuze, H.J. (2008) SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors. Traffic 9: 380-393.
  353. Passey, S., Bradley, A. & Mellor, H. (2008) Escherichia coli isolated from bovine mastitis invade mammary cells by a modified endocytic pathway. Vet Microbiol. 130: 151-64.
  354. Bujny, M.V., Ewels, P., Humphrey, S., Attar, N., Jepson, M.A. & Cullen, P.J. (2008) Sorting nexin-1 defines an early phase of Salmonella-containing vacuole remodeling during Salmonella infection. J. Cell Sci 121: 2027-36.
  355. Millard, T. & Martin, P (2008) Dynamic analysis of filopodial interactions during the zippering phase of Drosophila dorsal closure. Development 135, 621-6.
  356. Pula, G. & Poole, A.W. (2008) Critical roles for the actin cytoskeleton and cdc42 in regulating platelet integrin alpha2beta1. Platelets. 19: 199-210.
  357. Hodge, J.J. & Stanewsky, R. (2008) Function of the Shaw potassium channel within the Drosophila circadian clock. PLoS ONE 3: e2274.
  358. Mori, R., Shaw, T. & Martin, P. (2008) Molecular mechanisms linking wound inflammation and fibrosis - knockdown of osteopontin leads to rapid repair with reduced scarring. J. Exp Med. 205: 43-51.
  359. Stramer, B. Winfield, M., Shaw, T., Millard, T., Woolner, S. & Martin, P. (2008) Gene induction following wounding of wild type versus macrophage-deficient Drosophila embryos. EMBO Rep. 9, 465-471.
  360. Heyward, C.A., Pettitt, T.R., Leney, S.E., Welsh, G.I., Tavaré, J.M. & Wakelam, M.J. (2008) An intracellular motif of GLUT4 regulates fusion of GLUT4-containing vesicles. BMC Cell Biol. 20;9:25.
  361. Cvejic, A., Hall, C., Bak-Maier, Flores, MV., Crosier, P., M, Redd. M. & Martin, P. (2008) Live imaging and genetic dissection of WASp function during the in vivo wound inflammatory response of Zebrafish larvae. J. Cell Sci. 121: 3196-3206.
  362. Spooner, R.A., Watson, P.D., Smith, D.C., Boal, F., Amessou, M., Johannes, L., Clarkson, G.J., Lord, J.M., Stephens, D.J. & Roberts, L.M. (2008) The secretion inhibitor Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network. Biochem J. 414: 471-484.
  363. Benest, A.V., Stone, O.A., Miller, W.H., Glover, C.P., Uney, J.B., Baker, A.H., Harper, S.J. & Bates, D.O. (2008) Arteriolargenesis and angiogenesis induced by endothelial nitric oxide synthase overexpression results in a mature vasculature. Arterioscler. Thromb. Vasc. Biol. 28: 1462-1468.
  364. Mundell, S.J., Barton, J.F., Mayo-Martin, M.B., Hardy, A.R. & Poole, A.W. (2008) Rapid resensitization of purinergic receptor function in human platelets. J. Thromb. Haemost. 6: 534-543.
  365. Bond, M., Wu, Y.J., Sala-Newby, G.B. & Newby, A.C. (2008) Rho GTPase, Rac1, regulates Skp2 levels, vascular smooth muscle cell proliferation and intima formation in vitro and in vivo. Cardiovasc. Res. 80: 290-298.
  366. Verkade P., (2008) Moving EM: the Rapid Transfer System as a new tool for correlative light and electron microscopy and high throughput for high-pressure freezing. Journal of Microscopy, 230, Pt 2, 317–328
  367. Scott, A.N., Hetheridge, C., Reynolds, A.R., Nayak, V., Hodivala-Dilke, K. & Mellor, H. (2008) Farnesyltransferase inhibitors target multiple endothelial cell functions in angiogenesis. Angiogenesis. 11: 337-346.
  368. Townley, A.K., Feng, Y., Schmidt, K., Carter, D.A., Porter, R., Verkade, P. & Stephens, D.J. (2008) Efficient coupling of Sec23-Sec24 to Sec13-Sec31 drives COPII-dependent collagen secretion and is essential for normal craniofacial development. J. Cell Sci. 121: 3025-3034.
  369. Martinez-Argudo, I. & Jepson, M.A. (2008) Salmonella translocates across an in vitro M cell model independently of SPI-1 and SPI-2. Microbiology 154: 3887-3894.
  370. Lennon, R., Singh, A., Welsh, G.I., Coward, R.J., Satchell, S., Ni, L., Mathieson, P.W., Bakker, W.W. & Saleem, M.A. (2008) Hemopexin induces nephrin-dependent reorganization of the actin cytoskeleton in podocytes. J. Am. Soc. Nephrol. 19: 2140-2149.
  371. Kränkel, N., Katare, R.G., Siragusa, M., Barcelos, L.S., Campagnolo, P., Mangialardi, G., Fortunato, O., Spinetti, G., Tran, N., Zacharowski, K., Wojakowski, W., Mroz, I., Herman, A., Manning Fox, J.E., Macdonald, P.E., Schanstra, J.P., Bascands, J.L., Ascione, R., Angelini, G., Emanueli, C. & Madeddu, P. (2008) Role of kinin B2 receptor signaling in the recruitment of circulating progenitor cells with neovascularization potential. Circ. Res. 103: 1335-1343.
  372. Williamson, R.C., Brown, A.C., Mawby, W.J. & Toye, A.M. (2008) Human kidney anion exchanger 1 localisation in MDCK cells is controlled by the phosphorylation status of two critical tyrosines. J. Cell Sci. 121: 3422-3432.
  373. McKinnon, C.M., Lygoe, K.A., Skelton, L., Mitter, R. & Mellor, H. (2008) The atypical Rho GTPase RhoBTB2 is required for expression of the chemokine CXCL14 in normal and cancerous epithelial cells. Oncogene 27: 6856-6865.
  374. Hall, K.J., Harper, M.T., Gilio, K., Cosemans, J.M., Heemskerk, J.W. & Poole, A.W. (2008) Genetic analysis of the role of protein kinase C? in platelet function and thrombus formation. PLoS ONE. 3:e3277.

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    2009 Publications

  375. Jones, A.R., Kramer, E.M., Knox, K., Swarup, R., Bennett, M.J., Lazarus, C.M., Leyser, H.M. & Grierson, C.S. (2009) Auxin transport through non-hair cells sustains root-hair development. Nat. Cell Biol. 11: 78-84.
  376. Zubcevic, J., Waki, H., Diez-Freire, C., Gampel, A., Raizada, M.K. & Paton, J.F. (2009) Chronic blockade of phosphatidylinositol 3-kinase in the nucleus tractus solitarii is prohypertensive in the spontaneously hypertensive rat. Hypertension. 53: 97-103.
  377. Cunha, C.S., Griffiths, N.J., Murillo, I. & Virji, M. (2009) Neisseria meningitidis Opc invasin binds to the cytoskeletal protein alpha-actinin. Cellular Microbiol. 11:389-405.
  378. Perrett, C.A. & Jepson, M.A. (2009) Regulation of Salmonella-induced membrane ruffling by SipA differs in strains lacking other effectors. Cellular Microbiol. 11: 475-487.
  379. Pocha, S.M. & Cory, G.O. (2009) WAVE2 is regulated by multiple phosphorylation events within its VCA domain. Cell Motil.Cytoskeleton 66: 36-47.
  380. Clark, L., Martinez-Argudo, I., Humphrey, T.J. & Jepson, M.A. (2009) GFP plasmid-induced defects in Salmonella invasion depend on plasmid architecture, not protein expression. Microbiology 155: 461-467.
  381. Moss, D.K., Wilde, A. & Lane, J.D. (2009) Dynamic release of nuclear RanGTP triggers TPX2-dependent microtubule assembly during the apoptotic execution phase. J. Cell Sci. 122: 644-655.
  382. Desjobert, C., Noy, P., Swingler, T., Williams, H., Gaston, K. & Jayaraman, P.S. (2009) The PRH/Hex repressor protein causes nuclear retention of Groucho/TLE co-repressors. Biochem. J. 417: 121-132.
  383. Carter, D.A., Dick, A.D. & Mayer, E.J. (2009) CD133+ adult human retinal cells remain undifferentiated in Leukaemia Inhibitory Factor (LIF). BMC Ophthalmol. 23;9:1.
  384. Verhagen, J., Gabry, L., Minaee, S., Sabatos, C.A., Anderson, G., Sharpe, A.H. & Wraith, D.C. (2009) Enhanced selection of FoxP3+ T regulatory cells protects CTLA-4 deficient mice from CNS autoimmune disease. Proc. Natl. Acad. Sci. 106: 3306-3311.
  385. Howarth, J.L., Glover, C.P. & Uney, J.B. (2009) HSP70 interacting protein prevents the accumulation of inclusions in polyglutamine disease. J Neurochem. 108: 945-951.
  386. Stone, O.A., Richer, C., Emanueli, C., van Weel, V., Quax, P.H., Katare, R., Kraenkel, N., Campagnolo, P., Barcelos, L.S., Siragusa, M., Sala-Newby, G.B., Baldessari, D., Mione, M., Vincent, M.P., Benest, A.V., Al Haj Zen, A., Gonzalez, J., Bates, D.O., Alhenc-Gelas, F. & Madeddu, P. (2009) Critical role of tissue kallikrein in vessel formation and maturation. Implications for therapeutic revascularization. Arterioscler Thromb Vasc Biol. 29: 657-664.
  387. Konopatskaya, O., Gilio, K., Harper, M.T., Zhao, Y., Cosemans, J.M., Karim, Z.A., Whiteheart, S.W., Molkentin, J.D., Verkade, P., Watson, S.P., Heemskerk, J.W. & Poole, A.W. (2009) PKCa regulates platelet granule secretion and thrombus formation in mice. J. Clin. Invest. 119: 399-407.
  388. Howorth, P.W., Teschemacher, A.G. & Pickering, A.E. (2009) Retrograde adenoviral vector targeting of nociresponsive pontospinal noradrenergic neurons in the rat in vivo. J. Comp. Neurol. 512: 141-157.
  389. Rollason, R., Korolchuk, V., Hamilton, C., Jepson, M. & Banting, G. (2009) A CD317(tetherin)/RICH2 complex plays a critical role in the organisation of the sub-apical cytoskeleton in polarised epithelial cells. J. Cell Biol. 184: 721-736.
  390. Patsos, G., Hebbe-Viton, V., Robbe-Masselot, C., Masselot, D., Martin, R.S., Greenwood, R., Paraskeva, C., Klein, A., Graessmann, M., Michalski, J.C., Gallagher, T. & Corfield, A. (2009) O-glycan inhibitors generate aryl-glycans induce apoptosis and lead to growth inhibition in colorectal cancer cell lines. Glycobiology 19: 382-398.
  391. Brown, A.C., Hallouane, D., Mawby, W.J., Karet, F.E., Saleem, M.A., Howie, A.J. & Toye, A.M. (2009) RhCG is the major putative ammonia transporter expressed in human kidney and RhBG is not expressed at detectable levels. Am. J. Physiol. Renal Physiol. 296: F1279-90.
  392. Foster, R.R., Zadeh, M.A., Welsh, G.I., Satchell, S.C., Ye, Y., Mathieson, P.W., Bates, D.O. & Saleem, M.A. (2009) Flufenamic acid is a tool for investigating TRPC6-mediated calcium signalling in human conditionally immortalised podocytes and HEK293 cells. Cell Calcium. 45:384-90.
  393. Barcelos, L.S., Duplaa, C., Kränkel, N., Graiani, G., Invernici, G., Katare, R., Siragusa, M., Meloni, M., Campesi, I., Monica, M., Simm, A., Campagnolo, P., Mangialardi, G., Stevanato, L., Alessandri, G., Emanueli, C. & Madeddu, P. (2009) Human CD133+ progenitor cells promote the healing of diabetic ischemic ulcers by paracrine stimulation of angiogenesis and activation of Wnt signaling. Circ Res. 104: 1095-102.
  394. Wassmer, T., Attar, N., Harterink, M., van Weering, J.R., Traer, C.J., Oakley, J., Goud, B., Stephens, D.J., Verkade, P., Korswagen, H.C. & Cullen, P.J. (2009) The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network. Dev Cell. 17: 110-22.
  395. Betin, V.M. & Lane, J.D. (2009) Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis. J Cell Sci. 122: 2554-66.
  396. Brown, E., Mantell, J., Carter, D., Tilly, G. & Verkade, P. (2009) Studying intracellular transport using high-pressure freezing and correlative light electron microscopy. Semin Cell Dev Biol. 20: 910-9
  397. Balasubramaniam, B., Carter, D.A., Mayer, E.J. & Dick, A.D. (2009) Microglia derived IL-6 suppresses neurosphere generation from adult human retinal cell suspensions. Exp. Eye Res. 89: 757-66
  398. Lennon, R., Pons, D., Sabin, M.A., Wei, C., Shield, J.P., Coward, R.J., Tavaré, J.M., Mathieson, P.W., Saleem, M.A. & Welsh, G.I. (2009) Saturated fatty acids induce insulin resistance in human podocytes: implications for diabetic nephropathy. Nephrol. Dial. Transplant. 24: 3288-96
  399. Jones, M.L., Shawe-Taylor, A.J., Williams, C.M. & Poole, A.W. (2009) Characterization of a novel focal adhesion kinase inhibitor in human platelets. Biochem Biophys Res Commun. 389:198-203
  400. Lerner, R.G., Depatie, C., Rutter, G.A., Screaton, R.A. & Balthasar, N. (2009) A role for the CREB co-activator CRTC2 in the hypothalamic mechanisms linking glucose sensing with gene regulation. EMBO Rep. 10: 1175-81
  401. Hughes, H., Budnik, A., Schmidt, K.J., Johnson, A., Noakes, C., Carter, D.A., Verkade, P., Watson, P. & Stephens, D.J. (2009) Organization of human endoplasmic reticulum exit sites: requirements for the localization of Sec16 to transitional ER. J. Cell Science, 122: 2924-34.
  402. Stow, N. D., Evans, V. C. & Matthews, D. A. (2009). Upstream Binding Factor is sequestered into Herpes Simplex Virus type 1 replication compartments. J. Gen. Virol. , 90: 69-73.
  403. Perrett, C.A., Karavolos, M.H., Humphrey, S., Mastroeni, P., Martinez-Argudo, I., Spencer, H., Bulmer,D., Winzer, K., McGhie, E., Koronakis, V., Williams, P., Khan, C.M.A. & Jepson, M.A. (2009) LuxS-based quorum sensing does not affect the ability of Salmonella to express the SPI-1 Type 3 secretion system, induce membrane ruffles or invade epithelial cells. J. Bacteriol. 191: 7253-9.
  404. Howorth, P.W, Thornton, S.R., O'Brien, V., Smith, W.D., Nikiforova, N., Teschemacher, A.G. & Pickering, A.E. (2009) Retrograde viral vector-mediated inhibition of pontospinal noradrenergic neurons causes hyperalgesia in rats. J. Neurosci. 29: 12855-64.
  405. Gaiser, B.K., Fernandes, T.F., Jepson, M., Lead, J., Tyler, C.R. & Stone, V. (2009) Assessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments. Environmental Health, 8 Suppl 1:S2
  406. Budnik, A. & Stephens, D.J. (2009) ER exit sites - localization and control of COPII vesicle formation. FEBS Lett. 583: 3796-803.
  407. Bhabra, G., Sood, A., Fisher, B., Cartwright, L., Saunders, M., Evans, W.H., Surprenant, A., Lopez-Castejon, G., Mann, S., Davis, S.A., Hails, L.A., Ingham, E., Verkade, P., Lane, J., Heesom, K., Newson, R. & Case, C.P. (2009) Nanoparticles can cause DNA damage across a cellular barrier.Nat. Nanotechnol. 4: 876-83

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    2010 publications

  408. Moreira, S., Stramer, B., Evans, I., Wood, W. & Martin, P. (2010) Prioritization of competing damage and developmental signals by migrating macrophages in the Drosophila embryo. Curr. Biol. 20: 464-70
  409. Nisar, S., Kelly, E., Cullen, P.J. & Mundell, S.J. (2010) Regulation of P2Y receptor traffic by sorting nexin 1 is retromer independent. Traffic 11: 508-19
  410. Lam, Y.W., Evans, V.C., Heesom, K.J., Lamond, A.I. & Matthews, D.A. (2010) Proteomics analysis of the nucleolus in adenovirus-infected cells. Mol. Cell Proteomics 9: 117-30.
  411. Fan, L., Pellegrin, S., Scott, A. & Mellor, H. (2010) The small GTPase Rif is an alternative trigger for the formation of actin stress fibers in epithelial cells. J. Cell Sci. 123: 1247-52.
  412. Mundell, S.J., Matharu, A.L., Nisar, S., Palmer, T.M., Benovic, J.L. & Kelly, E. (2010) Deletion of the distal COOH-terminus of the A2B adenosine receptor switches internalization to an arrestin- and clathrin-independent pathway and inhibits recycling. Br. J. Pharmacol. 159: 518-33.
  413. Gilio, K., Harper, M.T., Cosemans, J.M., Konopatskaya, O., Munnix, I.C., Prinzen, L., Leitges, M., Liu, Q., Molkentin, J.D., Heemskerk, J.W. & Poole, A.W. (2010) Functional divergence of platelet protein kinase C (PKC) isoforms in thrombus formation on collagen. J. Biol. Chem. 285: 23410-9.
  414. Foster, R.R., Welsh, G.I., Satchell, S.C., Marlow, R.D., Wherlock, M.D., Pons, D., Mathieson, P.W., Bates, D.O. & Saleem, M.A. (2010) Functional distinctions in cytosolic calcium regulation between cells of the glomerular filtration barrier. Cell Calcium 48: 44-53.
  415. Sawasdichai, A., Chen, H.T., Abdul Hamid, N., Jayaraman, P.S. & Gaston, K. (2010) In situ subcellular fractionation of adherent and non-adherent mammalian cells. J.Vis. Exp. Jul 23;(41). pii: 1958. doi: 10.3791/1958.
  416. Boal, F., Guetzoyan, L., Sessions, R.B., Zeghouf, M., Spooner, R.A., Lord, J.M., Cherfils, J., Clarkson , G.J., Roberts, L.M. & Stephens, D.J. (2010) LG186: an inhibitor of GBF1 function that causes Golgi disassembly in human and canine cells. Traffic. 11: 1537-1551
  417. Shen, D.K., Saurya, S., Wagner, C., Nishioka, H. & Blocker, A.J. (2010) Domains of the Shigella flexneri type III secretion system IpaB protein involved in secretion regulation. Infect. Immun. 78: 4999-5010.
  418. Wu, F., Saleem, M.A., Kampik, N.B., Satchwell, T.J., Williamson, R.C., Blattner, S.M., Ni, L., Toth, T., White, G., Young, M.T., Parker, M.D., Alper, S.L., Wagner, C.A. & Toye, A.M. (2010) Anion exchanger 1 interacts with nephrin in podocytes. J. Am. Soc. Nephrol. 21: 1456-67.
  419. Ovens, M.J., Manoharan, C., Wilson, M.C., Murray, C.M., Halestrap, A.P. (2010) The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein. Biochem. J. 431: 217-25.
  420. Mahmoud, Z.N., Grundy, D.J., Channon, K.J. & Woolfson, D.N. (2010) The non-covalent decoration of self-assembling protein fibers. Biomaterials 31: 7468-7474
  421. Bromley, E.H.J., Channon, K.J., King, P.J.S., Mahmoud, Z.N., Banwell, E.F., Butler, M.F., Crump, M.J., Dafforn, T.E., Hicks, D.M.R., Hirst, J.D., Rodger, A. & Woolfson, D.N. (2010) Assembly pathway of a designed ?-helical protein fiber. Biophys. J. 98: 1668-1676
  422. Hughes, H. & Stephens, D.J. (2010) Sec16A defines the site for vesicle budding from the endoplasmic reticulum on exit from mitosis. J. Cell Sci. 123: 4032-8.
  423. Bochenek, M.L., Dickinson, S., Astin, J.W., Adams, R.H. & Nobes, C.D. (2010) Ephrin-B2 regulates endothelial cell morphology and motility independently of Eph-receptor binding. J. Cell Sci. 123: 1235-46.
  424. Brown, E. & Verkade, P. (2010) The use of markers for correlative light electron microscopy. Protoplasma 244: 91-97.
  425. Morohashi Y, Balklava Z, Ball M, Hughes H & Lowe M. (2010) Phosphorylation and membrane dissociation of the ARF exchange factor GBF1 in mitosis. Biochem J. 427, 401-12
  426. Guetzoyan, L., Spooner, R., Boal, F., Stephens, D.J., Lord, J.M., Roberts, L.M. & Clarkson, G.J. (2010) Fine tuning Exo2, a small molecule inhibitor of secretion and retrograde trafficking pathways in mammalian cells. Molecular BioSystems 6, 2030-8.
  427. Boal, F. & Stephens, D.J. (2010) Specific functions of BIG1 and BIG2 in endomembrane organization. PLOS One 5(3), e9898.
  428. Vanzyl B, Planas R, Ye Y, Foulis A, de Krijger RR, Vives-Pi M, Gillespie KM (2010) Why are levels of maternal microchimerism higher in type 1 diabetes pancreas? Chimerism 1: 45-50.
  429. van Weering, J.R., Brown, E., Sharp, T.H., Mantell, J., Cullen, P.J. & Verkade, P. (2010) Intracellular membrane traffic at high resolution. Methods Cell. Biol. 96: 619-48.
  430. Al Haj Zen, A., Oikawa, A., Bazan-Peregrino, M., Meloni, M., Emanueli, C. & Madeddu, P. (2010) Inhibition of delta-like-4-mediated signaling impairs reparative angiogenesis after ischemia.. Circ Res. 107: 283-93.
  431. Murillo, I. & Virji, M. (2010) Visualisation and quantification of intracellular interactions of Neisseria meningitidis and human ?-actinin by confocal maging. J Vis Exp. 2010 Oct 24;(44). pii: 2045. doi: 10.3791/2045.
  432. Campagnolo, P., Cesselli, D., Al Haj Zen, A., Beltrami, A.P., Kränkel, N., Katare, R., Angelini, G., Emanueli, C. & Madeddu, P. (2010)_Human adult vena saphena contains perivascular progenitor cells endowed with clonogenic and proangiogenic potential. Circulation 121: 1735-45.
  433. Cristofaro, B., Stone, O.A., Caporali, A., Dawbarn, D., Ieronimakis, N., Reyes, M., Madeddu, P., Bates, D. O. & Emanueli, C. (2010) Neurotrophin-3 is a novel angiogenic factor capable of therapeutic neovascularization in a mouse model of limb ischemia. Arterioscler. Thromb. Vasc. Biol. 30:1143-50.
  434. Stramer, B., Moreira, S., Millard, T., Evans, I., Huang, C-Y, Sabet, O., Milner, M., Dunn, G., Martin, P. & Wood, W. (2010) Clasp mediated microtubule bundling regulates persistent motility and contact repulsion in Drosophila macrophages in vivo. J. Cell Biol. 189: 681-689.
  435. Wang, Y., Nakayama, M., Pitulescu, M.E., Schmidt, T.S., Bochenek, M.L., Sakakibara, A., Adams, S., Davy, A., Deutsch, U., Lüthi, U., Barberis, A., Benjamin, L.E., Mäkinen, T., Nobes, C.D. & Adams, R.H . (2010) Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis. Nature 465: 483-6.
  436. Astin, J.W., Batson, J., Kadir, S., Charlet, J., Persad ,R.A., Gillatt, D., Oxley, J.D. & Nobes, C.D.(2010) Competition amongst Eph receptors regulates contact inhibition of locomotion and invasiveness in prostate cancer cells. Nat Cell Biol. 12: 1194-1204.
  437. Feng. Y, Santoriello, C., Mione, M., Hurlstone, A. & Martin, P. (2010) Live imaging of innate immune cell sensing of transformed cells in zebrafish larvae: parallels between tumor initiation and wound inflammation. PLoS Biol 8(12): e1001004. doi:10.1371/journal.pbio.1001004

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    2011 publications

  438. Matsubayashi, Y., Razzel, W. & Martin, P. (2011). “White wave” analysis of epithelial scratch wound healing reveals how cells mobilize back from the leading edge in a myosin II-dependent fashion. J Cell Sci. 124: 1017-21
  439. Humphrey, S., Clark, L.F., Humphrey, T.J. & Jepson, M.A. (2011) Enhanced recovery of Salmonella Typhimurium DT104 from exposure to stress at low temperature. Microbiology 157: 1103-1114
  440. Soloviev, S., Gallagher, J., Marnef, A. & Kuwabara, P.E. (2011) C. elegans patched-3 is an essential gene implicated in osmoregulation and requiring an intact permease transporter domain Developmental Biology 351: 242-253.
  441. King, M-J., Jepson, M.A., Guest, A. & Mushens, R. (2010) Detection of hereditary pyropoikilocytosis by the eosin-5-maleimide (EMA) binding test is attributable to a marked reduction of EMA-reactive transmembrane proteins. Int. J. Lab. Hematol. 33: 205-11
  442. Humphrey, S., MacVicar, T., Stevenson, A., Roberts, M., Humphrey, T.J. & Jepson M.A. (2011) SulA-induced filamentation in Salmonella enterica serovar Typhimurium: Effects on SPI-1 expression and epithelial infection. J.Appl. Microbiol. 111: 185-196.
  443. Clark, L., Perrett, C.A. Malt, L., Harward, C., Humphrey, S., Jepson, K., Martinez-Argudo, I., Carney, L.J., La Ragione, R.M., Humphrey, T.J.,& Jepson, M.A. (2011) Differences in Salmonella enterica serovar Typhimurium strain invasiveness is associated with heterogeneity in SPI-1 gene expression Microbiology 157: 2072-2083
  444. Katare, R., Caporali, A., Zentilin, L., Avolio, E., Sala-Newby, G., Oikawa, A., Cesselli, D., Beltrami, A.P., Giacca, M., Emanueli, C. & Madeddu, P. (2011) Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling. Circulation Research 108:1238-51.
  445. Davies, D. (2011) Cell-extracellular matrix versus cell-cell interactions during the development of the cochlear-vestibular ganglion. Neurosci. Res. 89: 1375-87
  446. Patel NN, Toth T, Jones C, Lin H, Ray P, George SJ, Welsh GI, Satchell SC, Angelini GD & Murphy GJ (2011) Prevention of post cardiopulmonary bypass acute kidney injury by endothelin-A receptor blockade. Crit. Care Med. 39: 793-802.
  447. Satchwell TJ, Bell AJ, Pellegrin S, Kupzig S, Ridgwell K, Daniels G, Anstee DJ, van den Akker E, & Toye AM. (2011) Critical band 3 multiprotein complex interactions establish early during human erythropoiesis. Blood. 118: 182-91
  448. Konopatskaya O, Matthews SA, Harper MT, Gilio K, Cosemans JM, Williams CM, Navarro MN, Carter DA, Heemskerk JW, Leitges M, Cantrell D & Poole AW.(2011) Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2. Blood. 118: 416-24.
  449. Hartfield EM, Rinaldi F, Glover CP, Wong LF, Caldwell MA & Uney JB. (2011) Connexin 36 expression regulates neuronal differentiation from neural progenitor cells. PLoS One 6:e14746.
  450. Correia Carreira S, Cartwright L, Mathiesen L, Knudsen LE & Saunders M. (2011) Studying placental transfer of highly purified non-dioxin-like PCBs in two models of the placental barrier. Placenta 32: 283-91.
  451. Kadir S, Astin JW, Tahtamouni L, Martin P & Nobes CD. (2011) Microtubule remodelling is required for the front-rear polarity switch during contact inhibition of locomotion. J. Cell Sci. 124: 2642-53.
  452. Maddocks SE, Wright CJ, Nobbs AH, Brittan JL, Franklin L, Strömberg N, Kadioglu A, Jepson MA & Jenkinson HF (2011) Streptococcus pyogenes antigen I/II family polypeptide AspA shows differential ligand-binding properties and mediates biofilm formation. Mol. Microbiol. 81: 1034-49
  453. Harterink M, Port F, Lorenowicz MJ, McGough IJ, Silhankova M, Betist MC, van Weering JR, van Heesbeen RG, Middelkoop TC, Basler K, Cullen PJ, Korswagen HC. (2011) A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion. Nat. Cell Biol.13: 914-23.
  454. Gutierrez-Mecinas M, Trollope AF, Collins A, Morfett H, Hesketh SA, Kersante F, Reul JM. (2011) Long-lasting behavioral responses to stress involve a direct interaction of glucocorticoid receptors with ERK1/2-MSK1-Elk-1 signaling. Proc Natl Acad Sci U S A. 108: 13806-11
  455. Razzell W, Wood W & Martin P. (2011) Swatting flies: modelling wound healing and inflammation in Drosophila. Dis Model Mech. 4: 569-74
  456. Katare R, Riu F, Mitchell K, Gubernator M, Campagnolo P, Cui Y, Fortunato O, Avolio E, Cesselli D, Beltrami AP, Angelini G, Emanueli C & Madeddu P. (2011) Transplantation of human pericyte progenitor cells improves the repair of infarcted heart through activation of an angiogenic program involving micro-RNA-132. Circulation Research 109: 894-906.
  457. Nisar S, Daly ME, Federici AB, Artoni A, Mumford AD, Watson SP & Mundell SJ. (2011) An intact PDZ-motif is essential for correct P2Y12 purinoceptor traffic in human platelets. Blood 118: 5641-51.
  458. Bass MD, Williamson RC, Nunan RD, Humphries JD, Byron A, Morgan MR, Martin P & Humphries MJ (2011) A syndecan-4 hair trigger initiates wound healing through caveolin- and RhoG-regulated integrin endocytosis. Developmental Cell 21: 681-93.
  459. Patel NN, Lin H, Toth T, Jones C, Ray P, Welsh GI, Satchell SC, Sleeman P, Angelini GD & Murphy GJ (2011) Phosphodiesterase-5 inhibition prevents post cardiopulmonary bypass acute kidney injury in swine. Ann.Thoracic Surg. 92(6):2168-76
  460. Patel NN, Lin H, Toth T, Welsh GI, Jones C, Ray P, Satchell SC, Sleeman P, Angelini GD & Murphy GJ (2011) Reversal of anaemia with allogenic RBC transfusion prevents post cardiopulmonary bypass acute kidney injury in swine. Am. J. Physiol.-Renal Physiol. 301: F605-14
  461. Hetheridge C, Mavria G, Mellor H. (2011) Uses of the in vitro endothelial-fibroblast organotypic co-culture assay in angiogenesis research. Biochem Soc Trans. 39: 1597-600.
  462. Krishna Kumar R, Yu X, Pati, A , Li M, Mann S (2011) Cytoskeletal-like supramolecular assembly and nanoparticle-based motors in a model protocell, Angew. Chem. Int. Ed. 50: 9343-9347

    463. back to top


    2012 publications

  463. van Weering JR, Verkade P, Cullen PJ (2012) SNX-BAR-mediated endosome tubulation is coordinated with endosome maturation. Traffic 13: 94-107
  464. Gaiser BK, Fernandes TF, Jepson MA, Lead JR, Tyler CR, Baalousha M, Biswas A, Britton G, Cole PA, Johnston BD, Ju-Nam Y, Rosenkranz P, Scown TM & Stone V (2012) Interspecies comparisons on the uptake and toxicity of silver and cerium dioxide nanoparticles. Env. Toxicol. Chem. 31: 144-54
  465. Brozzi F, Diraison F, Lajus S, Rajatileka S, Philips T, Regazzi R, Fukuda M, Verkade P, Molnár E, Váradi A. (2012) Molecular mechanism of myosin Va recruitment to dense core secretory granules. Traffic. 13: 54-69
  466. Cartwright L, Poulsen MS, Nielsen HM, Knudsen LE, Saunders M, Rytting E (2012) In vitro placental model optimization for nanoparticle transport studies. Int. J. Nanomed. 7: 497-510

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