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Dr Anna Chambers

Dr Anna Chambers

Dr Anna Chambers
MBiochem(Oxon), PhD(Bristol)

CRUK Career Development Fellow

Area of research

Chromatin Remodelling and Genome Stability

Office D50/D40
Biomedical Sciences Building,
University Walk, Clifton BS8 1TD
(See a map)

Tel. +44 (0) 117 331 1622

Research summary

In eukaryotes, DNA is packaged into chromatin.  The basic unit of chromatin is the nucleosome, formed by the wrapping of DNA around an octamer of histones proteins.  In order for efficient DNA repair to occur, manipulation of chromatin structure is necessary.   These changes to chromatin organisation include covalent modification of histone proteins, incorporation of histone variants and ATP-dependent chromatin remodelling and defects in these processes can result in genome instability, one of the hallmarks of cancer cells. 

The focus of our research group is in understanding the function of chromatin and ATP-dependent chromatin remodelling complexes in ...

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Biography

MBiochem (Oxon), PhD (Bristol)

CRUK Career Development Fellow

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Recent publications

  • Sutton, AJ, Vohra, RS, Hollyman, M, Marriott, PJ, Buja, A, Alderson, D, Pasquali, S, Griffiths, EA, Vohra, RS, Spreadborough, P, Hollyman, M, Marriott, PJ, Kirkham, A, Pasquali, S, Alderson, D, Griffiths, EA, Fenwick, S, Elmasry, M, Nunes, QM, Kennedy, D, Khan, RB, Khan, MA, Magee, CJ, Jones, SM, Mason, D, Parappally, CP, Mathur, P, Saunders, M, Jamel, S, Haque, SU, Zafar, S, Shiwani, MH, Samuel, N, Dar, F, Jackson, A, Lovett, B, Dindyal, S, Winter, H, Fletcher, T, Rahman, S & others 2017, ‘Cost-effectiveness of emergency versus delayed laparoscopic cholecystectomy for acute gallbladder pathology’. British Journal of Surgery, vol 104., pp. 98-107
  • Sutton, AJ, Vohra, RS, Hollyman, M, Marriott, PJ, Buja, A, Alderson, D, Pasquali, S, Griffiths, EA, Vohra, RS, Spreadborough, P, Hollyman, M, Marriott, PJ, Kirkham, A, Pasquali, S, Alderson, D, Griffiths, EA, Fenwick, S, Elmasry, M, Nunes, QM, Kennedy, D, Khan, RB, Khan, MA, Magee, CJ, Jones, SM, Mason, D, Parappally, CP, Mathur, P, Saunders, M, Jamel, S, Haque, SU, Zafar, S, Shiwani, MH, Samuel, N, Dar, F, Jackson, A, Lovett, B, Dindyal, S, Winter, H, Fletcher, T, Rahman, S & others 2017, ‘Cost-effectiveness of emergency versus delayed laparoscopic cholecystectomy for acute gallbladder pathology’. British Journal of Surgery, vol 104., pp. 98-107

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View complete publications list in the University of Bristol publications system

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