Browse/search for people

Professor Catherine Nobes

Professor Catherine Nobes

Professor Catherine Nobes
BSc, PhD(Lond)

Professor of Cell Biology and Head of School

Area of research

Regulation of cell migration and cancer cell invasion by Eph receptors and ephrins

Office D30.g
School of Medical Sciences,
University Walk, Clifton BS8 1TD
(See a map)

+44 (0) 117 331 2164

Summary

Our work is of relevance to tumour cell motility and invasion. We are interested in understanding the molecular pathways that direct cancer cells away from the primary tumour and how the tumour microenvironment contributes to cancer cell migration and metastasis.

We work on a phenomenon known as contact inhibition of locomotion; collisions between migrating cells lead to collapse of actin-driven cell protrusions and a change in the direction of migration. Many cancer cells fail to show contact inhibition of locomotion when confronted to normal cells and this switch to attractive migratory behaviour has been suggested to underlie invasive metastasis. We have shown that EphB receptors are upregulated in metastatic prostate cancer cells and are functionally required for attractive migration after contact with stromal fibroblasts and endothelial cells.

My group continues to focus on how Eph-ephrin signalling regulates cell migration and cell-cell interactions in the context of cancer and wound healing.

Memberships

Organisations

School of Biochemistry

Other sites

School of Biochemistry staff

Links

Recent publications

View complete publications list in the University of Bristol publications system

Edit this profile If you are Professor Catherine Nobes, you can edit this page. Login required.

PDF versionDownload PDF