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Dr Christopher Dempsey

Dr Christopher Dempsey

Dr Christopher Dempsey
B.Sc.(St.And.), Ph.D.(Lond.)

Senior Lecturer in Biochemistry

Area of research

Structure and Function of Membrane Ion Channel Proteins

Office C52
Biomedical Sciences Building,
University Walk, Clifton BS8 1TD
(See a map)

Tel. +44 (0) 117 42 82161

Research summary

Membrane ion channel, transport, and receptor proteins embedded within cell membranes carry out much of the membrane transport and communication functions of the cell. A class of ion channel proteins that respond to changes in membrane potential allow selective flow of ions across the cell membrane to generate action potentials in excitable tissue such as neurons or heart muscle. In collaboration with Jules Hancox in the School of Physiology and Pharmacology at Bristol, we are building atomic scale models of K+ channel proteins to understand the structural basis for the effects of channel mutations and for promiscuous drug binding in ...

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Biography

Chris Dempsey researches into the molecular basis of membrane ion channel function. He graduated with a degree in Chemistry from St Andrews University in Scotland and did his PhD with Charles Vernon in the Chemistry Department at University College, London. Interests in NMR spectroscopy and spectroscopic analysis of membrane proteins developed during postdoctoral work at Oxford University. Following a period in Don Engelman's lab at Yale University studying molecular biology and membrane protein expression he returned to the UK and Bristol University.

Chris is currently using computer simulations to study the molecular basis of drug binding to a human ...

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Selected publications

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View complete publications list in the University of Bristol publications system

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