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Miss Claire Noble

Miss Claire Noble

Miss Claire Noble

Demonstrator
Teaching Support Assistant

Senate House,
Tyndall Avenue, Clifton BS8 1TH
(See a map)

Tel. +44 (0) 117 331 2136

Research summary

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Biography

My research is in the field of de novo enzyme design, aiming to produce new proteins with oxidoreductase activity. I am primarily based in Ross Anderson's group, which utilises a ‘maquette’ approach to enzyme design – combining simple helical bundles with redox active cofactors such as heme to engineer new activity. I am aiming to use computational biochemistry tools such as Rosetta and Amber to design new proteins, which can then be expressed and biochemically characterised in the lab. My second, computational, supervisor is Adrian Mulholland. I hope to use QM/MM calculations to further computationally characterise the enzymatic reactivity of ...

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