The Collinson Lab explore the molecular mechanisms underlying protein translocation across biological membranes for the purposes of transport across (protein secretion and mitochondrial import) and into phospholipid bilayers (membrane protein insertion).
The group studies the ubiquitous Sec machinery using the tractable model organism E. coli by a comprehensive characterisation of function and structure. The structure of the core-SecY translocon responsible for secretion, both alone and in complex with a pre-protein mimic, has been determined in collaboration with Profs Tom Rapoport and Werner Kühlbrandt. Current efforts explore how the free energy available from ATP hydrolysis and the trans-membrane proton motive force ...
Ian Collinson's research interests lie in the structure, function and exploitation of large multimeric membrane protein complexes. He obtained his PhD in Cambridge with Sir John Walker studying the mitochondrial machinery responsible for ATP synthesis. These interests were subsequently developed during international postdoctoral work at the Max-Planck-Institute of Biophysics (EMBO Fellowship with Prof Werner Kühlbrandt) and the Harvard Medical School (HFSP Fellowship with Prof Tom Rapoport) to the mechanisms cells deploy for the export of secretory proteins and the insertion of membrane proteins.
The Collinson lab has been established in Bristol since 2004, where research is focused on protein secretion ...
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