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Dr Jon Lane

Dr Jon Lane

Dr Jon Lane
B.Sc.(Soton.), Ph.D.(Exon.)

Reader in Cell Biology

Area of research

Molecular regulation of autophagy

Office Room C.49a
Biomedical Sciences Building,
University Walk, Clifton BS8 1TD
(See a map)

Tel. +44 (0) 117 331 2115

Research summary

My lab is interested in autophagy - the regulated recycling of cytoplasmic material through delivery and degradation in the lysosome. 

Please visit the Lab website http://thelanelab.wordpress.com 

Follow Jon on Twitter @Jon_D_Lane

Autophagy (macroautophagy) is characterised by the formation of double membrane-bound organelles that sequester regions of cytoplasm including misfolded protein aggregates and organelles.The autophagosome membrane is decorated with a protein known as Atg8 (commonly known as LC3), which plays roles in autophagosome assembly and cargo selection.

We use live-cell imaging as well as fixed cell microscopy (including electron microscopy) to explore how and where autophagosomes ...

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Biography

I set up my lab in 2003 with the award of a Research Career Development Fellowship from the Wellcome Trust. This followed PhD training with Dr Howard Stebbings in Exeter and Postdoctoral training in molecular motors and membrane trafficking in Profs Viki Allan and Philip Woodman’s labs in Manchester. In particular, this period of training provided important insight into the control of ER membrane dynamics and structure through cell-based and cell-free assay systems. Microtubules, motors, organelle dynamics and membrane traffic have been unifying themes of my research so far, and it was applying this knowledge to the understanding of membrane ...

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Recent publications

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View complete publications list in the University of Bristol publications system

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