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Professor Leo Brady

Professor Leo Brady

Professor Leo Brady
BSc(Macq), DPhil(York)

Professor of Biochemistry

Area of research

Structural biology of pathogenesis

Office C.101d
Biomedical Sciences Building,
University Walk, Clifton BS8 1TD
(See a map)

+44 (0) 117 903 5516
+44 (0) 117 33 11828

Summary

As a structural biologist, I am interested in understanding biological systems at a molecular level. This is achieved by primarily using the technique of protein crystallography. A principal focus of our studies is the study and exploitation of proteins central to human disease. Our work is interdisciplinary, encompasses both basic and applied studies, and we work in close collaboration with a wide range of academic and industrial groups. 

Career research highlights include:

  • The first structure of a lipase [Nature (1989) 343, 767-770], and two fungal amylases [Biochemistry 29, 6244-6249]. These structures have since contributed to protein engineering studies resulting in improved recombinant products with both medical and commercial applications.
  • HIV Proteins:  Studies of the HIV receptor, CD4 [Science (1989) 260, 979-983], and the integrase enzyme from the virus [TIBTech, 15, 167-172], a challenging drug target on which we worked closely with both Glaxo and Proteus, a small UK-based biotechnology company. From these studies a strong interest in structure-based drug design techniques emerged.
  • Immune System proteins: We worked with Celltech to determine a number of engineered antibody structures [J. Mol. Biol. (1992) 227, 253-264; Proteins SF&G (1997) 29, 161-171] which contributed to the development of products now commercialised by Celltech as diagnostic and therapeutic reagents for the treatment of colonic and breast cancers. Our fortuitous discovery that recombinant forms of the CD2 receptor could adopt more than one protein fold [PNAS (1995) 92, 7337-7341] provided us with a unique opportunity to probe the folding pathway and evolution of immunoglobulin domains [Nature Struct. Biol. (1998) 5, 778-782; J. Mol. Biol.(1999) 285, 1857-1867].
  • Anti-malarials and Dehydrogenases:  With GSK we developed potential drugs against the lactate dehydrogenase from Plasmodium falciparum - the causative agent of malaria [Nature Struct. Biol.(1996) 3, 912-915; J. Biol. Chem. (1999) 274, 10213-1021, J. Biol. Chem. (2004)  279, 30, 31429-31439] and have also studied the PfATPase6 transporter, one of the targets of artemisinins [Nature Struct. & Molec. Biology (2005) 12, 628 – 629].
  • Other interests include neuroscience targets (neurotrophin-TrkB complex, Structure (2001) 9, 1191-1199); the RKIP/PEBP family of signalling proteins and their relationship to cell growth and oncology [Structure (1998) 6, 1245-1254, EMBO J (2006) 25, 605-614], bacterial adh esins and novel vaccines [EMBO J. (2008) 27, 1779-89; PNAS  (2011) 108, 15174-15178]; and most recently an expanding programme of designer proteins for synthetic biology  [Nature Chem Biol  (2011] 7, 935-941; PNAS.(2012) 109(33)13266-71, J. Am. Chem Soc.(2013)135(34),12524-12527].

Biography

  • Professor of Biochemistry, University of Bristol (2001 - present)
  • Head of the School of Biochemistry, University of Bristol (2009-2014)
  • Reader in Biochemistry, University of Bristol (1996-2001)
  • Lecturer in Biochemistry, University of Bristol (1994-1996)
  • MRC AIDS Senior Fellow, University of York/University of Bristol (1990-1995)
  • Postdoctoral Fellow, University of York (1988-1990)
  • Research Assistant, Dept of Chemistry, University of York (1985-1987)
  • Research Assistant, Yale University, CT, USA (1984-1985)
  • Research Assistant, University of Sydney (1983-1984)

Teaching

First Year Units:

  • BIOC10100 Biochemistry 1G
  • BIOC10001 Biological Chemistry 1A - Unit Organiser

 

Second Year Units:

  • BIOC20201 Organisation and Communication in Cells

 

Third Year Units:

  • BIOC30600  Advanced Options in Biochemistry BIOC30600
  • BIOC30603  Core Skills

 

Current PhD students:

  • Chris Wood: Protein Design (with Prof Dek Woolfson)
  • Ahmad Farizzulkhairi Ahmad Sobri: Bacterial Pathogenesis Factors
  • Storm McCready-Fallon: Targeted Trypanosomal Drug Design (with Prof Wendy Gibson)
  • Matt Brewer: Bacterial Adhesins (with Dr Darryl Hill)

 

 

 

Keywords

  • Structural biology
  • protein crystallography
  • drug design
  • cell surface receptors
  • bacterial adhesins
  • designer proteins
  • malaria
  • trypanosomes

Memberships

Organisations

School of Biochemistry

School of Biochemistry staff

Recent publications

View complete publications list in the University of Bristol publications system

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