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Dr Lucy MacCarthy-Morrogh

Dr Lucy MacCarthy-Morrogh

Dr Lucy MacCarthy-Morrogh
B.A.(Dub.), Ph.D.(Lond.)

Senior Scientific Officer

Area of research

Investigating innate immune cells when they interact with very early stage tumours

Office Rooms F.22 & FW4
Biomedical Sciences Building,
University Walk, Clifton BS8 1TD
(See a map)

+44 (0) 117 331 2209
+44 (0) 117 331 2210

Summary

Using a zebrafish melanoma model my project aims to correlate live confocal imaging with transmission electron microscopy in order to investigate fine cellular detail regarding what is going on when pre-neoplastic tumour cells and innate immune cells interact, see Live imaging of innate immune cell sensing of transformed cells inzebrafish larvae: parallels between tumor initiation and wound inflammation.Feng Y, Santoriello C, Mione M, Hurlstone A, Martin P.PLoS Biol. 2010 Dec 14;8(12).

I work closely on this project with Debbie Carter, who is a specialized EM technician. The EM images have revealed extremely interesting details that are not visible by light/flourescent microscopy, and they have given rise to novel questions regarding both how innate immune cells interact with cancer cells, and also how the immune cells initially gain access to cancer cells which are compartmentalised by basement membrane.

 

Biography

Currently I work as a scientific officer in Paul Martin's group where I work on my own research project, lab management, and student supervision.

I graduated with a degree in Natural Sciences (Genetics) from Dublin University, and from The Institute of Child Health at UCL with a PhD (Molecular Immunology). 

Memberships

Organisations

School of Biochemistry

Recent publications

View complete publications list in the University of Bristol publications system

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