The research focus of the group is the mechanistic analysis of genome processing and maintenance by protein-based molecular machines. These enzyme systems are fundamental to biological events such as gene copying, expression and repair, but are also important as the basis of many new technologies, such as the emergent genome editing.
We have adopted a dual experimental approach to studying DNA-protein interactions – combining single molecule microscopy with ensemble biochemistry, the latter including millisecond time-resolution rapid-mixing fluorescence spectroscopy, molecular biology and protein chemistry. More recently we have established collaborations to extend our studies to human cell culture.
Mark has always had a soft spot for DNA. He studied Biochemistry at the University of Liverpool, followed by training in enzymology with Bernard Connolly (Southampton) and Steve Halford FRS (Bristol), elucidating the roles of short- and long-range DNA interactions by restriction enzymes. Supported by the award of a Wellcome Trust Career Development Fellowship, he established his research group in Bristol in 1998. He was amongst the first in the UK to propose applying a combination of single-molecule and ensemble biochemical techniques to the study of genome rearrangements. Following on from the award of a Wellcome Trust Senior Fellowship in ...
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