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Professor Mark Dillingham

Professor Mark Dillingham

Professor Mark Dillingham
B.Sc.(Bristol), Ph.D.(Oxon.)

Professor of Biochemistry

Office Room D.46
Biomedical Sciences Building,
University Walk, Clifton BS8 1TD
(See a map)

Tel. +44 (0) 117 3312159

Research summary

Helicases as modular components of DNA processing machines

Helicases are motor proteins that translocate along and unwind duplex nucleic acids into their component single strands in an ATP-dependent manner. They are exceptionally abundant enzymes and constitute about 1% of the proteome. Accordingly, they are involved in a wide variety of nucleic acid transactions including DNA replication, repair, recombination and transcription and virtually every aspect of RNA metabolism. Our research is focused on uncovering the role of such helicases in complex DNA manipulations, including the processing of broken DNA for repair by homologous recombination and the resolution of conflicts between DNA ...

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Biography

Mark Dillingham's research is in the field of DNA:protein interactions. He obtained his D. Phil. in Oxford with Dale Wigley studying the structure and mechanism of DNA helicases.  This research was developed further in postdoctoral study at the University of California at Davis (with Steve Kowalczykowski) and at the National Institute for Medical Research (with Martin Webb) which focused on how helicase motors were integrated into larger machines, such as those responsible for the repair of double-stranded DNA breaks.

The Dillingham laboratory was established in Bristol in 2005. Our recent and current work has focussed on the mechanisms of ...

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Recent publications

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View complete publications list in the University of Bristol publications system

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