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Publication - Professor Paul Martin

    The wound inflammatory response exacerbates growth of pre-neoplastic cells and progression to cancer

    Citation

    Antonio, N, Bønnelykke-Behrndtz, ML, Ward, LC, Collin, J, Christensen, IJ, Steiniche, T, Schmidt, H, Feng, Y & Martin, P, 2015, ‘The wound inflammatory response exacerbates growth of pre-neoplastic cells and progression to cancer’. EMBO Journal, vol 34., pp. 2219-36

    Abstract

    There is a long-standing association between wound healing and cancer, with cancer often described as a "wound that does not heal". However, little is known about how wounding, such as following surgery, biopsy collection or ulceration, might impact on cancer progression. Here, we use a translucent zebrafish larval model of Ras(G12V)-driven neoplasia to image the interactions between inflammatory cells drawn to a wound, and to adjacent pre-neoplastic cells. We show that neutrophils are rapidly diverted from a wound to pre-neoplastic cells and these interactions lead to increased proliferation of the pre-neoplastic cells. One of the wound-inflammation-induced trophic signals is prostaglandin E2 (PGE2). In an adult model of chronic wounding in zebrafish, we show that repeated wounding with subsequent inflammation leads to a greater incidence of local melanoma formation. Our zebrafish studies led us to investigate the innate immune cell associations in ulcerated melanomas in human patients. We find a strong correlation between neutrophil presence at sites of melanoma ulceration and cell proliferation at these sites, which is associated with poor prognostic outcome.

    Full details in the University publications repository