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Publication - Dr Paul Race

    The Assembly Line Enzymology of Polyketide Biosynthesis

    Citation

    Race, P & Till, M, 2016, ‘The Assembly Line Enzymology of Polyketide Biosynthesis’. in: Bradley S Evans (eds) Nonribosomal Peptide and Polyketide Biosynthesis: Methods and Protocols. Springer, pp. 31-49

    Abstract

    Polyketides are a structurally and functionally diverse family of bioactive natural products that have found widespread application as pharmaceuticals, agrochemicals, and veterinary medicines. In bacteria complex polyketides are biosynthesized by giant multifunctional megaenzymes, termed modular polyketide synthases (PKSs), which construct their products in a highly coordinated assembly line-like fashion from a pool of simple precursor substrates. Not only is the multifaceted enzymology of PKSs a fascinating target for study, but it also presents considerable opportunities for the reengineering of these systems affording access to functionally optimized unnatural natural products. Here we provide an introductory primer to modular polyketide synthase structure and function, and highlight recent advances in the characterization and exploitation of these systems.

    Full details in the University publications repository