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Professor Andrew Halestrap

Professor Andrew Halestrap

Professor Andrew Halestrap
MA(Cantab), PhD, DSc(Bristol), FMedSci

Senior Research Fellow in Biochemistry
Emeritus Professor

Area of research

Mitochondria and cell death; monocarboxylate (lactate) transporters

Office 65 St Michaels Hill Room 2.4
Biomedical Sciences Building,
University Walk, Clifton BS8 1TD
(See a map)

Tel. +44 (0) 117 331 2118

Research summary

The mechanism of the mitochondrial permeability transition and its role in heart reperfusion injury:

In conditions such as ischaemic heart disease and stroke, mitochondria experience oxidative stress and become overloaded with Ca2+. This leads to the opening of a non-specific pore in the inner mitochondrial membrane, the mitochondrial permeability transition pore (MPTP), that destroys the functional integrity of mitochondria and leads to cell death. It can be inhibited by the immunosuppressant drugs Cyclosporin A and Sanglifehrin A.

We are studying the molecular mechanism of the MPTP and how its inhibition can protect the hearts from the damaging effects of ...

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Recent publications

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View complete publications list in the University of Bristol publications system

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