The endosomal network comprises a series of interconnected membrane bound compartments that in regulating the sorting and signaling of proteinaceous cargoes including receptors, transporters and adhesion molecules, orchestrates and fine-tunes numerous cellular processes. A major challenge is to achieve a thorough molecular description of how this network operates, and in so doing, how defects contribute to the pathoetiology of human disease.
To date our understanding of endosomal sorting has been restricted by a tendency to focus on individual ‘model’ cargoes, and the ‘isolated’ characterization of protein complexes that define individual sorting events. To achieve a thorough understanding we must break ...
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