The design of new proteins and enzymes remains one of the great challenges in biochemistry and tests our fundamental understanding of the nature of protein as a material. Unlocking the exceptionally diverse and powerful array of chemistries that natural enzymes perform promises routes to new drugs, therapies and green industrial processes.
Most approaches to this end have focused on modifying natural proteins and enzymes to impart new or altered catalytic function with varying degrees of success. The problems associated with such alterations are due to the layers of complexity that nature incorporates through natural selection into a protein’s complicated three-dimensional ...
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