Protein folding and chaperone mechanisms
One of the fundamental unsolved problems in biological science is how the sequence of a protein dictates its active 3-dimensional structure. If we can find a solution, two fundamental advances would result. Firstly, we would be able to convert DNA sequence data into their encoded 3-D protein structures and, secondly, we could begin to design protein molecules with new structure. Following on from a successful experimental programme which sought to characterise the folding process, we are now using computer-based studies to model this process with the aim of structure prediction. Ongoing experimental programmes seek to identify the molecular mechanisms of chaperones and their influence on protein folding.
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