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Professor Adrian Mulholland

Professor Adrian Mulholland

Professor Adrian Mulholland
B.Sc.(Bristol), D.Phil.(Oxon.)

Professor

Office W237
School of Chemistry,
Cantock's Close, Bristol BS8 1TS
(See a map)

+44 (0) 117 928 9097

Expertise

Most biochemical reactions depend on enzyme catalysis, and understanding how enzymes 'work' at the molecular level is a fundamental problem. Enzymes are remarkably efficient and specific catalysts, but despite intensive experimental investigations, the detailed origins of their rate accelerations remain unclear. This question is of crucial importance in Biology, and also for the development of protein catalysts for practical applications. Better understanding is vital for analysing the activities of mutant or designed proteins, and for the design of inhibitors as pharmaceutical lead compounds in drug design. It also promises to contribute in predcitions of drug metabolism.

  • enzyme catalysis
  • quantum mechanics/molecular mechanics qm/mm methods
  • computational biochemistry
  • enzymology
  • modelling biological molecules
  • drug design
  • drug metabolism
  • Memberships

    Organisations

    School of Chemistry

    Other sites

    Links

    Recent publications

    View complete publications list in the University of Bristol publications system

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