Dr Matthew Avison
Senior Lecturer in Microbiology
School of Cellular and Molecular Medicine,
University of Bristol, Medical Sciences Building,
Bristol, BS8 1TD
phone: +44 (0)117 33 12036 (internal 12036)
email: matthewb.avison@bristol.ac.uk
Research interests
- Novel Two-component signal transduction systems in bacteria - functional genomic analyses.
- Regulation of chromosomal β-lactamase expression in Gram-negative bacteria of clinical importance - biochemical and molecular genetic analyses.
- Functional analysis and regulation of multidrug efflux pump expression in Gram-negative bacteria.
- Bioinformatic analysis of evolutionary rules in DNA.
- Predicting evolutionary potential of mobile antimicrobial drug resistance genes.
Present collaborators
- Prof Alasdair MacGowan (CMM and Southmead Hospital)
- Prof Charles Penn (Birmingham)
- Prof Julian Parkhill and Dr Lisa Crossman (Sanger Institute, Cambridge)
- Prof Keith Poole (Queens University, Canada)
- Dr Juan Ayala (CBM, Madrid)
- Dr Nigel Savery (Biochemistry)
- Dr Vicky Enne (Queen Mary, University of London)
- Dr Max Dow (University College, Cork)
Selected publications
- Tayler, A.E., Ayala, J.A., Niumsup, P., Westphal, K., Baker, J.A., Zhang, L., Walsh, T.R., Wiedemann, B., Bennett, P.M., & Avison, M.B. (2010) Induction of β-lactamase production in Aeromonas hydrophila is responsive to β-lactam-mediated changes in peptidoglycan composition. Microbiology 156, 2327-2335.
- Cariss, S.J., Constantinidou, C., Patel, M.D., Takebayashi, Y., Hobman, J.L., Penn, C.W., and Avison, M.B. (2010) YieJ (CbrC) mediates CreBC-dependent colicin E2 tolerance in Escherichia coli. Journal of Bacteriology 192, 3329-3336.
- Ryan, R.P., Monchy, S., Cardinale, M., Taghavi, S., Crossman, L.C., Avison, M.B., Berg, G., van der Lelie, D., and Dow, J.M. (2009) The versatility and adaptation of bacteria from the genus Stenotrophomonas. Nature Reviews Microbiology 7, 414-425.
- Crossman, L.C., Gould, V.C., Dow, J.M., Vernikos, G.S., Okazaki, A., Sebaihia, M., Saunders, D., Arrowsmith, C., Carver, T., Peters, N., Adlem, E., Kerhornou, A., Lord, A., Murphy, L., Seeger, K., Squares, R., Rutter, S., Quail, M.A., Rajandream, M.A., Harris, D., Churcher, C., Bentley, S.D., Parkhill, J., Thomson, N.R. and Avison, M.B. (2008) The complete genome, comparative and functional analysis of Stenotrophomonas maltophilia reveals an organism heavily shielded by drug resistance determinants. Genome Biol. 9, R74, 13pp.
- Cariss, S.J.L., Tayler, A.E. and Avison, M.B. (2008) Defining the growth conditions and promoter-proximal DNA sequences required for activation of gene expression by CreBC in Escherichia coli. J. Bacteriol. 190, 3930-3939.
- Okazaki, A. and Avison, M.B. (2008) Induction of L1 and L2 β-lactamase production in Stenotrophomonas maltophilia is dependent on an AmpR-type regulator. Antimicrob. Agents Chemother. 52, 1525-1528.
- Hobman, J.L., Patel, M.D., Hidalgo-Arroyo, G.A., Cariss, S.J.L., Avison, M.B., Penn, C.W. and Constantinidou, C. (2007) Comparative genomic hybridization detects secondary chromosomal deletions in Escherichia coli K-12 MG1655 mutants and highlights instability in the flhDC region. J. Bacteriol. 189, 8786-9792.
- Fouhy, Y., Scanlon, K., Schouest, K., Spillane, C., Crossman, L., Avison, M.B., Ryan, R.P. and Dow, J.M. (2007) Diffusible signal factor-dependent cell-cell signaling and virulence in the nosocomial pathogen Stenotrophomonas maltophilia. J. Bacteriol. 189, 4964-4968.
- Okazaki, A. and Avison, M.B. (2007) Characterization of Aph(3')-IIc, an aminoglycoside resistance determinant from Stenotrophomonas maltophilia. Antimicrob. Agents Chemother. 51, 359-360.