Dr David Morgan
Reader in Immunology
School of Cellular and Molecular Medicine,
University of Bristol, Medical Sciences Building,
Bristol, BS8 1TD
phone: +44 (0)117 33 12021 (internal 12021)
email: d.j.morgan@bristol.ac.uk
Research interests
For several years my laboratory has been interested in studying the interaction between CD8+ T cells and self antigens derived from peripheral tissues or tumor cells. We have generated a number of model systems with which to define those factors which influence whether CD8+ T cell tolerance or immunity occurs.
Current projects are as follows:
- To examine the role of dendritic cells (DC) during CD8+ T cell tolerance induction and autoimmunity to pancreatic self-antigens expressed by pancreatic islet β cell.
- To define the factors associated with both CD8+ T cells and tumor cells which influence the generation of effective anti-tumour responses.
- To determine the role of prostaglandins during anti-tumor CD8+ T cell responses.
- Manipulation of leukaemia cells in order to generate CTL responses
- Development of novel vaccine approaches to combat human tumours
Selected publications
- Ahmadi, M., Emery, D.C. and Morgan, D.J. Prevention of both direct and indirect priming of anti-tumor CD8+ T cell responses following over-expression of Cyclooxygenase-2 by tumour cells in vivo. Nature Medicine, In Press.
- Ahmadi M, Emery DC, and Morgan, D.J. (2008) Prevention of both direct and cross-priming of antitumor CD8+ T-cell responses following overproduction of prostaglandin E2 by tumor cells in vivo. Cancer Research 68, 7520-7529.
- Janicki, C.N., Jenkinson, S.R., Williams, N.A. and Morgan, D.J. (2008) Loss of CTL function among high avidity tumor-specific CD8+ T cells following tumor infiltration. Cancer Research 68, 2993-3000.
- Raveney, B.J.E. and Morgan, D.J. (2007) Dynamic control of self-specific CD8+ T cell responses via a combination of signals mediated by dendritic cells. J. Immunol. 179, 2870-2879.
- Fraser, J.M., Janicki, C.N., Raveney B.J. and Morgan, D.J. (2006) Abortive activation precedes functional deletion of CD8 T cells following encounter with self-antigens expressed by resting B cells in vivo. Immunol. 119, 126-133.
- Jenkinson, S.R., Williams, N.A. and Morgan, D.J. (2005) The role of intercellular adhesion molecule-1/LFA-1 interactions in the generation of tumor-specific CD8+ T cell responses. J. Immunol. 174, 3401-3407.