Professor Stuart Siddell
A mouse coronavirus (image © Dr David Bhella, University of Glasgow)
Professor of Virology
School of Cellular and Molecular Medicine,
University of Bristol, Medical Sciences Building,
Bristol, BS8 1TD
phone: +44 (0)117 33 12067 (internal 12067)
email: stuart.siddell@bristol.ac.uk
Research interests
- Molecular biology, genetics and pathogenesis of coronaviruses
- Diagnosis of Feline Coronavirus diseases
- Development of coronavirus antivirals and vaccines
My research focuses on the structure and function of the coronavirus replication machinery with the goal of identifying novel targets for the development of anti-coronaviral drugs. I have also established and apply coronavirus reverse genetics to the development of novel, live, attenuated coronavirus vaccines. Currently, I am particularly interested in coronavirus proteins that modulate the innate immune response (especially the type 1 interferon response), the adaptation of these proteins during transmission across species, and the manipulation of these proteins to produce coronavirus vaccines. My research includes the study of human coronaviruses, in particular the SARS-coronavirus (SARSCoV), and animal coronaviruses of veterinary importance, for example, Feline infectious peritonitis virus (FIPV). I also study the genetics and pathogenesis of Murine hepatitis virus (MHV), which shares many similarities with SARSCoV.
Present co-workers
- Dr Severine Tasker, Companion Animal Studies (PhD, MRCVS)
- Dr Chris Helps, Langford Veterinary Services (BSc (Hons), PhD)
- Kathryn Cosgrove, (BVSc, BSc (Hons), PhD student)
- Emily Porter (BSc (Hons), PhD student)
Selected publications
- Züst, R., Cervantes-Barragan, L., Habjan, M., Maier, R., Neuman, B.W., Ziebuhr, J., Szretter, K.J., Baker, S.C., Barchet, W., Diamond, M.S., Siddell, S.G., Ludewig, B., Thiel, V. (2011) Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5. Nat. Immunol. 12:137-143.
- Neuman, B.W., Kiss, G., Kunding, A.H., Bhella, D., Baksh, M.F., Connelly, S., Droese, B., Klaus, J.P., Makino, S., Sawicki, S.G., Siddell, S.G., Stamou, D.G., Wilson, I.A., Kuhn, P., Buchmeier, M.J. (2010) A structural analysis of M protein in coronavirus assembly and morphology. J. Struct. Biol. 2010 Dec 3. [Epub ahead of print]
- Stokes, H.L., Baliji, S., Chang, G.H., Sawicki, S.G., Baker, S.C. and Siddell, S.G. (2010) A new cistron in the Murine Hepatitis Virus replicase gene. J. Virol. 84, 10148-10158.
- Roth-Cross, J.K., Stokes, H., Chang, G., Chua, M.M., Thiel, V., Weiss, S.R., Gorbalenya, A.E. and Siddell, S.G. (2009) Organ-specific attenuation of Murine Hepatitis Virus (MHV-A59) by replacement of catalytic residues in the putative viral cyclic phosphodiesterase NS2. J. Virol. 83, 3743-3753.
- Siddell, S.G. and Snijder, E.J. (2008) An Introduction to Nidoviruses, In: S. Perlman et al. (eds), The Nidoviruses, ASM Press, Washington.
- Sawicki, S.G., Sawicki, D.L. and Siddell, S.G. (2007) A contemporary view of coronavirus transcription. J. Virol. 81, 20-29.
- Sawicki, S.G., Sawicki, D.L., Younker, D., Meyer, V., Thiel, V., Stokes, H. and Siddell, S.G. (2005) Functional and genetic analysis of coronavirus replicase-transcriptase proteins. PLoS Pathogens 1, e39.