Professor David Wraith
Professor of Experimental Pathology
School of Cellular and Molecular Medicine,
University of Bristol, Medical Sciences Building,
Bristol, BS8 1TD
phone: +44 (0)117 33 12054 (internal 12054)
email: d.c.wraith@bristol.ac.uk
Research interests
- Presentation of self and foreign antigens to the immune system
- Control of autoimmune disease by regulatory T cells
- The specific immunotherapy of allergenic and autoimmune diseases with synthetic antigens
Selected publications
- Kemp, K.C., Gordon, D., Wraith, D.C., Mallam, E.A., Hartfield, E., Uney, J.B., Wilkins, A. and Scolding, N. (2011) Fusion between human mesenchymal stem cells and cerebellar Purkinje cells. Neuropathology and Applied Neurobiology 37, 166-178.
- Gabryšová, L. and Wraith, D.C. (2010) Antigenic strength controls the generation of antigen-specific IL-10-secreting T regulatory cells. European J. Immunol. 40, 1386-1395.
- Mazza, G., Sabatos-Peyton, C., Protheroe, R. and Wraith, D.C. (2010) Isolation and characterization of human interleukin (IL)-10-secreting T cells from peripheral blood. Human Immunol. 71, 225-234.
- Willison, H.J. and Wraith, D.C. (2010) A hazardous vapour trail from abattoir to neuropathy clinic. Lancet Neurology 9, 22-24.
- Wraith, D.C., Pope, R., Butzkueven, H., Holder, H., Vanderplank, P., Lowrey, P., Day, M.J., Gundlach, A.L., Kilpatrick, T.J., Scolding, N. and Wynick, D. (2009) A role for galanin in human and experimental inflammatory demyelination. Proc. Natl. Acad. Sci. (USA) 36, 15466-15471.
- Gabryšová, L., Nicolson, K.S., Streeter, H.B., Verhagen, J., Sabatos-Peyton, C.A., Morgan, D.J., and Wraith, D.C. (2009) Negative feedback control of the autoimmune response through antigen-induced differentiation of IL-10-secreting Th1 cells. J. Experimental Med. 206, 1755-1767.
- Verhagen, J., Gabryšová, L., Minaee, S., Sabatos, C.A., Anderson, G., Sharpe, A.H. and Wraith, D.C. (2009) Enhanced selection of FoxP3+ T-regulatory cells protects CTLA-4-deficient mice from CNS autoimmune disease. Proc. Natl. Acad. Sci. (USA) 106, 3306-3311.
- Wraith, D.C. (2009) Therapeutic peptide vaccines for treatment of autoimmune diseases. Immunol. Letts. 122, 134-136.
- Gordon, D., Pavlovska, G., Glover, C.P., Uney, J.B., Wraith, D.C. and Scolding, N.J. (2008) Human mesenchymal stem cells abrogate experimental allergic encephalomyelitis after intraperitoneal injection and with sparse CNS infiltration. Neuroscience Letters, 448, 71-73.
- Lüth, S., Huber, S., Schramm, C., Buch, T., Zander, S., Stadelmann, C., Brück, W., Wraith, D.C., Herkel, J. and Lohse, A.W. (2008) Ectopic expression of neural autoantigen in liver suppresses experimental autoimmune neuroinflammation by inducing antigen-specific Treg cells. J. Clin. Invest. 118, 3403-3410.
- Zhu, B., Symonds, A.L.J., Martin, JE., Kioussis, D., Wraith, D.C., Li, SL. and Wang P. (2008) Early growth response gene 2 (Egr-2) controls the self-tolerance of T cells and development of lupus-like autoimmune disease. J. Experimental Med. 205, 2295-2307.
- Hollander, A.P., and Wraith, D.C. (2008) Stem Cell Immunology. In Advances in Tissue Engineering. S. M. S. E. H. Julia Polak, ed. World Scientific Publishing, London, Chapter 10.
- O'Connor, R.A., Prendergast, C.T., Sabatos, C.A., Lau, C.W.Z., Leech, M.D., Wraith, D.C. and Anderton, S.M. (2008) Th1 cells facilitate the entry of Th17 cells to the central nervous system during experimental autoimmune encephalomyelitis. J. Immunol. 181, 3750-3754.
- Dayan, C.M. and Wraith, D.C. (2008) Preparing for first-in-man studies: the challenges for translational immunology post-TNG1412. Clin. and Experimental Immunol. 151, 231–234.
- Verhagen, J., Sabatos, C.A. and Wraith, D.C. (2008) The role of CTLA-4 in immune regulation. Immunol. Letts., 115 73-74.