Professor Anthony P. Hollander
Photograph © Melissa Temple‑Smith
Arthritis Research UK Professor of Rheumatology and Tissue Engineering
School of Cellular and Molecular Medicine,
University of Bristol, Medical Sciences Building,
Bristol, BS8 1TD
phone: +44 (0)117 33 12403 (internal 12403)
email: a.hollander@bristol.ac.uk
Head of School
group: Adult Stem Cells
Research interests
Background
Anthony Hollander is the Arthritis Research UK Professor of Rheumatology and Tissue Engineering at the University of Bristol and Head of The School of Cellular and Molecular Medicine. He has many years experience in cartilage biology and his research is particularly focused on osteoarthritis. He also has a more general expertise in the wider fields of stem cells and tissue engineering. In 2010 the “Times” newspaper ranking of Britain’s 100 most important scientists included him at 39th on the list.
Specific research interests
- Osteoarthritis and treatment of cartilage degradation
- Biomarkers of osteoarthritis
- Cartilage tissue engineering from chondrocytes (cartilage cells)
- Cartilage tissue engineering from stem cells
- Tracheal tissue engineering
- Stem cell treatments for congenital heart disease
Biography
Professor Anthony Hollander has been working in the field of cartilage biology and arthritis research for two decades. Three of those years were spent at the internationally recognised cartilage laboratory at McGill University in Montreal. More recently he has focused on tissue engineering and stem cell biology for cartilage repair.
Professor Hollander has received funding in excess of £5 million of peer-reviewed funding over the past 10 years from The UK government, medical charities, the EU framework programmes and from biotechnology companies. He has been the named inventor on several patents. He is co-founder and Scientific Director of a University of Bristol spin-out company, Azellon Cell Therapeutics.
His work includes a study on the regulation of stem cell differentiation for cartilage repair and has pioneered the development of new assays and methodological approaches for the measurement of repair tissue quality in very small biopsies of cartilage from patients with knee injuries.
In 2008, Professor Hollander and a team of scientists and surgeons successfully created and then transplanted the first tissue-engineered trachea (windpipe), using a patient's own stem cells. The bioengineered trachea immediately provided the patient with a normally functioning airway, thereby saving her life.
Professor Hollander is Secretary General of The International Cartilage Repair Society and from September 2010 he will be vice president/president-elect of the Society. He is Associate Editor of a leading journal, Osteoarthritis and Cartilage. He is an editorial board member for several other journals.
Media experience
Professor Hollander has extensive experience working with the media through interviews with International newspapers, television and radio. He has also contributed to a number of live radio programmes, discussing stem cells and their potential in medicine.
Selected publications
- Hollander, A.P., Dickinson, S.C. and Kafienah, W. (2010) Stem cells and cartilage development: complexities of a simple tissue. Stem Cells 28(11):1992-1996. doi: 10.1002/stem.534
- Pabbruwe, M.B., Kafienah, W., Tarlton, J.F., Mistry, S., Fox, D.J. and Hollander, A.P. (2010) Repair of meniscal cartilage white zone tears using a stem cell/collagen-scaffold implant. Biomaterials 31(9):2583-2591.
- Hollander, A., Macchiarini, P., Gordijn, B. and Birchall, M. (2009) The first stem cell-based tissue-engineered organ replacement: implications for regenerative medicine and society. Regen. Med. 4(2):147-148.
- Asnaghi, M.A., Jungebluth, P., Raimondi, M.T., Dickinson, S.C., Rees, L.E., Go, T., Cogan, T.A., Dodson, A., Parnigotto, P.P., Hollander, A.P., Birchall, M.A., Conconi, M.T., Macchiarini, P. and Mantero, S. (2009) A double-chamber rotating bioreactor for the development of tissue-engineered hollow organs: from concept to clinical trial. Biomaterials 30(29):5260-5269.
- Pabbruwe, M.B., Esfandiari, E., Kafienah, W., Tarlton, J.F. and Hollander, A.P. (2009) Induction of cartilage integration by a chondrocyte/collagen-scaffold implant. Biomaterials 30(26):4277-4286.
- Macchiarini, P., Jungebluth, P., Go, T., Asnaghi, M.A., Rees, L.E., Cogan, T.A., Dodson, A., Martorell, J., Bellini, S., Parnigotto, P.P., Dickinson, S.C., Hollander, A.P., Mantero, S., Conconi, M.T. and Birchall, M.A. (2008) Clinical application of a tissue-engineered airway replacement. Lancet 372(9655):2023-2030.
- Kafienah, W., Mistry, S., Perry, M.J., Politopoulou, G. and Hollander, A.P. (2007) Pharmacological regulation of adult stem cells: chondrogenesis can be induced using a synthetic inhibitor of the retinoic acid receptor. Stem Cells 25, 2460-2468.
- Kafienah, W., Mistry, S., Dickinson, S.C., Sims, T.J., Learmonth, I. and Hollander, A.P. (2007) Three-dimensional cartilage tissue engineering using adult stem cells from osteoarthritis patients. Arthritis Rheum. 56, 177-187.
View all publications held on the University of Bristol's IRIS database