Special Colloids Seminar
Lecture Theatre 4
Professor Carmen Galan, University of Bristol
"With a little bit of sugar …. novel synthetic tools for glycobiology research"
O-Glycosylation is a ubiquitous post-translational modification that is highly dynamic and responsive to cellular stimuli through the action of the cycling enzymes. Expression of specific O-glycans is linked to changes in gene expression in, for example, inflammatory bowel disease, cystic fibrosis and several types of cancer.1
Glycan coated-nanoparticles constitute a good bio-mimetic model of carbohydrate presentation at the cell surface and provide a powerful tool to screen for protein carbohydrate interactions and consequently for the identification of carbohydrate receptors or ligands associated with many inter- and intracellular recognition processes associated to disease. In order to develop and use these glyco-tools for biomedical applications, it is of the utmost importance to have access to structurally defined oligosaccharide-based probes.
In recent years, our group has developed fluorescent multivalent O-glycan probes for the screening of O-glycosylation-linked interactions in live cells and more recently in bacteria. In this presentation, we will discuss our more recent results on the synthesis of fluorescent nanoparticles and their potential applications as diagnostic tools and drug delivery systems.2
(1) M. C. Galan*, D. Benito-Alifonso and G. M. Watt. Carbohydrate Chemistry in Drug Discovery. Org. Biomol. Chem. (2011), 9 (10), 3598 - 3610.
(2) a) Benito-Alifonso, D.; Tremel, S.; Hou, B.; Lockyear, H.; Mantell, J.; Fermin, D. J.; Verkade, P.; Berry, M.; Galan, M. C. Angew Chem Int Edit 2014, 53, 810. b) S. A. Hill, D. Benito-Alifonso, D.J. Morgan, S.A. Davis, M. Berry, M. C. Galan* Nanoscale 2016 , 8, 18630.