Chemical and Synthetic Biology Research theme Seminar - Professor Stuart Conway, University of Oxford

26 February 2020, 1.00 PM - 26 February 2020, 2.00 PM

Lecture Theatre 3

Chemical and Synthetic Biology Research theme Seminar

Speaker - Professor Stuart Conway, University of Oxford 

Title - ‘The development of chemical tools to study epigenetics and hypoxia’

The first part of the lecture will focus on the development of ligands for the CREBBP bromodomain. CREBBP (also CBP or KAT3A) is a transcriptional co-activator and key node in the human protein-protein interactome, binding to over 400 other protein partners. The second part of the lecture will focus on the development of hypoxia-activated pro-drugs. Histone or lysine deacetylase (H/KDAC) inhibitors inhibit the removal of acetyl groups from lysine residues, and have been approved for use in a number of oncology indications.

Academic Host - Professor Matt Crump 

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