Chemical and Synthetic Biology Research theme Seminar - Professor Stuart Conway, University of Oxford
Lecture Theatre 3
Chemical and Synthetic Biology Research theme Seminar
Speaker - Professor Stuart Conway, University of Oxford
Title - ‘The development of chemical tools to study epigenetics and hypoxia’
The first part of the lecture will focus on the development of ligands for the CREBBP bromodomain. CREBBP (also CBP or KAT3A) is a transcriptional co-activator and key node in the human protein-protein interactome, binding to over 400 other protein partners. The second part of the lecture will focus on the development of hypoxia-activated pro-drugs. Histone or lysine deacetylase (H/KDAC) inhibitors inhibit the removal of acetyl groups from lysine residues, and have been approved for use in a number of oncology indications.
Academic Host - Professor Matt Crump