Towards Ideality - Research from the School of Chemistry published by the Journal of the American Chemical Society
13 April 2015
Towards Ideality: The Synthesis of (+)-Kalkitoxin and (+)-Hydroxyphthioceranic Acid by Assembly-Line Synthesis
Congratulations to Sebastien Balieu, Gayle Hallett, Matthew Burns, Teerawut Bootwicha, John Studley (Vertex Pharmaceuticals ltd) & Varinder Aggarwal for their latest paper in the Journal of the American Chemical Society entitled Towards Ideality: The Synthesis of (+)-Kalkitoxin and (+)-Hydroxyphthioceranic Acid by Assembly-Line Synthesis. This paper has been featured in a spotlight article and is also highlighted on the front cover.
The cover shows the stylized working of a molecular assembly line and conveys the overall process of how different groups can be added to a growing carbon chain with high fidelity and how these groups also control the overall shape of the molecule. The methodology has been applied to the fully stereocontrolled and short syntheses of kalkitoxin and 10-hydroxyphthioceranic acid.
Journal of the American Chemical Society, Volume 137, Issue 13, Pages 4275-4592