School of Chemistry Research published in ACIE
30 October 2015
Research carried out by Dr John Bower, PhD student Giacomo Crisenza and summer placement Olga Sokolova published by ACIE
The paper Branch-Selective Alkene Hydroarylation by Cooperative Destabilization: Iridium-Catalyzed ortho-Alkylation of Acetanilides outlines the design and scope of an Ir(I)-catalyst system that promotes branch selective insertion of mono-substituted alkenes into aniline ortho-C-H bonds.
This provides a viable alternative to notoriously challenging Friedel-Crafts alkylations. The substituted aniline products are valuable building blocks for a diverse array of synthetically challenging N-heteroaromatic compounds.