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New aza-Heck reaction for the preparation of complex N-heterocyclic ring systems

6 April 2018

New research from Paul Pringle, John Bower and colleagues outlines a new aza-Heck reaction for the preparation of complex N-heterocyclic ring systems.

Ligand-enabled aza-Heck cyclizations and cascades of N-(pentafluorobenzoyloxy)carbamates are described. These studies encompass the first examples of efficient non-biased 6- exo aza-Heck cyclizations. The methodology provides direct and flexible access to carbamate protected pyrrolidines and piperidines.

Further information

Pyrrolidines and Piperidines by Ligand-Enabled Aza-Heck Cyclizations and Cascades of N-(Pentafluorobenzoyloxy)carbamates - Angewandte Chemie

Ian R. Hazelden, Rafaela C. Carmona, Thomas Langer, Paul G. Pringle, and John F. Bower

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