Dr Chris Arthur

Research summary

Biological Mass Spectrometry

Cells operate at three main levels. The genomic, in which information on how the cell functions is stored within its DNA. Proteomic, how is the genomic information is converted into proteins and enzymes that actually do the work of the cell? Metabolomic, what small molecules do the enzymes make? when? how much and why?

Mass spectrometry allows us to get a handle on the proteomic and metabolomic cell functions. This might include, identifying a protein of interest in a disease to quantifying how much of a particular hormone is in a sample at any one time.

Biosynthesis ...

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Links

• Dr Chris Arthur's LinkedIn profile
• Dr Chris Arthur's Blog
• Dr Chris Arthur's Youtube Channel

Selected publications

• Dall'Aglio, P, Arthur, C, Williams, C, Vasilakis, K, Maple, HJ, Crosby, J, Crump, MP & Hadfield, AT 2011, ‘Analysis of Streptomyces coelicolor Phosphopantetheinyl Transferase, AcpS, Reveals the Basis for Relaxed Substrate Specificity’. Biochemistry, vol 50., pp. 5704-5717
• Barker, E, Helps, C, Heesom, K, Arthur, C, Peters, I, Hofmann-Lehmann, R & Tasker, S 2010, ‘Detection of humoral response using a recombinant heat shock protein 70 (dnaK) of Mycoplasma haemofelis in experimentally and naturally hemoplasma infected-cats’. Clinical and Vaccine Immunology, vol 17 (12)., pp. 1926 - 1932

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Recent publications

• Fonseca, M, Arthur, C, Bromley, E, Samyn, B, Moerman, P, Saavedra, M, Correia, A & Spencer, J 2011, ‘Biochemical characterization of Sfh-I, the subclass B2 metallo-{beta}-lactamase from Serratia fonticola UTAD54’. Antimicrobial Agents and Chemotherapy, vol 55., pp. 5392 - 5395
• Barker, E, Darby, A, Helps, C, Peters, I, Heesom, K, Arthur, C, Crossett, B, Hughes, M, Radford, A & Tasker, S 2011, ‘Molecular characterization of the uncultivatable hemotropic bacterium Mycoplasma haemofelis’. Veterinary Research, vol 42 (83)., pp. 1 - 8

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