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Publication - Professor Craig Butts

    Enabling Fast Pseudo-2D NMR Spectral Acquisition for Broadband Homonuclear Decoupling

    The EXACT NMR Approach

    Citation

    Ndukwe, IE, Shchukina, A, Zorin, V, Cobas, C, Kazimierczuk, K & Butts, CP, 2017, ‘Enabling Fast Pseudo-2D NMR Spectral Acquisition for Broadband Homonuclear Decoupling: The EXACT NMR Approach’. ChemPhysChem, vol 18., pp. 2081?2087

    Abstract

    Pseudo-2D NMR spectroscopy provides a means of acquiring broadband homonuclear decoupled spectra useful for structural characterization of complex molecules. However, data points concatenated in the direct dimension in these experiments are acquired over incremented time periods-leading to long acquisition times with no sensitivity benefits due to the absence of signal averaging between scans. Herein, the concept of EXACT NMR spectroscopy ("burst" non-uniform sampling of data points) is explored in pseudo-2D experiments with results revealing little or no loss in spectral quality or signal intensity despite the acceleration of acquisition-up to 400% in some cases.

    Full details in the University publications repository