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Publication - Professor Craig Butts

    Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis

    Citation

    Williams, K, Szwalbe, AJ, Dickson, C, Desson, TR, Mulholland, NP, Vincent, JL, Clough, JM, Bailey, AM, Butts, CP, Willis, CL, Simpson, TJ & Cox, RJ, 2017, ‘Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis’. Chemical Communications, vol 53., pp. 7965-7968

    Abstract

    The biosynthesis of the herbicide cornexistin in the fungus Paecilomyces variotii was investigated by full sequencing of its genome, knockout of key genes within its biosynthetic gene cluster and isolation and identification of intermediate compounds. The general biosynthetic pathway resembles that of byssochlamic acid and other nonadrides in the early stages, but differs in requiring fewer enzymes in the key nonadride dimerisation step, and in the removal of one maleic anhydride moiety.

    Full details in the University publications repository