Research in our group is driven by the development and discovery of new carbon-carbon and carbon-heteroatom bond forming processes. In particular, we target methods that are operationally simple, green (atom and step economy) and selective (chemo-, regio- and stereoselectivity). In this context, asymmetric transition metal-catalysed processes are of particular interest.
The discovery of fundamental reactivity naturally leads to new opportunities in synthetic methodology, total synthesis and mechanism. Current research efforts are focused upon (i) the development of new methodology for heterocyclic chemistry, (ii) the application of these processes to natural product synthesis, (iii) the evaluation of natural product analogues for medicinal purposes and (iv) understanding reaction mechanism to increase the efficiency, scope and applicability of new transformations.
1. M. H. Shaw, E. Y. Melikhova, D. P. Kloer, W. G. Whittingham and J. F. Bower*; Directing group enhanced carbonylative ring expansions of amino-substituted cyclopropanes: rhodium catalyzed multicomponent synthesis of N-heterobicyclic enones. J. Am. Chem. Soc. 2013, In press.
2. A. Faulkner, J. S. Scott and J. F. Bower*; Palladium catalyzed cyclizations of oxime esters with 1,1-disubstituted alkenes: synthesis of α,α-disubstituted dihydropyrroles and studies towards an asymmetric protocol. Chem. Commun. 2013, 49, 1521-1523.
3. A. Faulkner and J. F. Bower*; Highly efficient Narasaka-Heck cyclizations mediated by P(3,5-(CF3)2C6H3)3: facile access to N-heterobicyclic scaffolds. Angew. Chem. Int. Ed. 2012, 51, 1675-1679.
John Bower obtained his M.Sci. degree in Chemistry in 2003 from the University of Bristol. He then remained at Bristol to study for his Ph.D. degree (2007) under the guidance of Professor Timothy Gallagher. During this time his research focused on the development of cyclic sulfamidate based N-heterocyclic methodologies and their application to natural product synthesis. His first postdoctoral appointment (2007-2008) was with Professor Michael Krische at the University of Texas at Austin where he investigated transfer hydrogenative strategies for carbonyl addition. He then undertook a second postdoctoral appointment with Professor Timothy Donohoe at the University of Oxford where he focussed on the use of olefin cross metathesis for heteroaryl synthesis. In 2010, he was awarded a Royal Society University Research Fellowship and commenced his independent career at the University of Bristol. The group’s research interests lie broadly within the area of asymmetric catalysis with a particular focus on metal-catalysed processes and their application to heterocyclic chemistry. A special emphasis is placed on the development of green processes (i.e. atom economy, step economy and selectivity).
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