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Publication - Professor John Bower

    Enantioselective Aza-Heck Cyclizations of N-(Tosyloxy)carbamates

    Synthesis of Pyrrolidines and Piperidines


    Ma, X, Hazelden, I, Langer, T, Munday, R & Bower, J, 2019, ‘Enantioselective Aza-Heck Cyclizations of N-(Tosyloxy)carbamates: Synthesis of Pyrrolidines and Piperidines’. Journal of the American Chemical Society, vol 141., pp. 3356-3360


    Pd(0)-systems modified with SPINOL-derived phosphoramidate ligands promote highly enantioselective aza-Heck cyclizations of alkenyl N-(tosyloxy)carbamates. The method provides versatile access to challenging N-heterocycles and represents
    the broadest scope enantioselective aza-Heck protocol developed so far.

    Full details in the University publications repository