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Publication - Professor John Bower

    New Initiation Modes for Directed Carbonylative C-C Bond Activation

    Rhodium-Catalyzed (3+1+2) Cycloadditions of Aminomethylcyclopropanes


    Wang, G, McCreanor, N, Shaw, M, Whittingham, WG & Bower, J, 2016, ‘New Initiation Modes for Directed Carbonylative C-C Bond Activation: Rhodium-Catalyzed (3+1+2) Cycloadditions of Aminomethylcyclopropanes’. Journal of the American Chemical Society, vol 138., pp. 13501-13504


    Under carbonylative conditions, neutral Rh(I)-systems modified with weak donor ligands (AsPh3 or 1,4-oxathiane) undergo N-Cbz, N-benzoyl or N-Ts directed insertion into the proximal C-C bond of aminomethylcyclopropanes to generate rhodacyclopentanone intermediates. These are trapped by N-tethered alkenes to provide complex perhydroisoindoles.

    Full details in the University publications repository