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Publication - Professor Kevin Booker-Milburn

    Pd(II)-Catalyzed [4 + 2] Heterocyclization Sequence for Polyheterocycle Generation


    Glaisyer, EL, Watt, MS & Booker-Milburn, KI, 2018, ‘Pd(II)-Catalyzed [4 + 2] Heterocyclization Sequence for Polyheterocycle Generation’. Organic Letters, vol 20., pp. 5877-5880


    A new Pd(II)-catalyzed cascade sequence for the formation of polyheterocycles, from simple starting materials, is reported. The sequence is applicable to both indole and pyrrole substrates, and a range of substituents are tolerated. The reaction is thought to proceed by a Pd(II)-catalyzed C-H activated Heck reaction followed by a second Pd(II)-catalyzed aza-Wacker reaction with two Cu(II)-mediated Pd(0) turnovers per sequence. The sequence can be considered a formal [4 + 2] heterocyclization.

    Full details in the University publications repository