Browse/search for people

Publication - Dr Natalie Pridmore

    Photoactivated Functionizable Tetracarbonyl(phenylpyridine)manganese(I) Complexes as CO-Releasing Molecules

    A Direct Suzuki–Miyaura Cross-Coupling on a Thermally Stable CO-RM

    Citation

    Ward, JS, Bray, JT, Aucott, BJ, Wagner, C, Pridmore, NE, Whitwood, AC, Moir, JW, Lynam, JM & Fairlamb, IJ, 2016, ‘Photoactivated Functionizable Tetracarbonyl(phenylpyridine)manganese(I) Complexes as CO-Releasing Molecules: A Direct Suzuki–Miyaura Cross-Coupling on a Thermally Stable CO-RM’. European Journal of Inorganic Chemistry, vol 2016., pp. 5044-5051

    Abstract

    A new class of carbon monoxide-releasing molecules (CO-RMs) are reported based on a previously known tetracarbonyl phenylpyridine manganese(I) motif. A pre-functionalized CO-RM undergoes a direct Pd-catalysed Suzuki–Miyaura cross-coupling with phenylboronic acid to give a π-extended three-ring CO-RM. Cross-coupling conditions were modified to allow coupling of a morpholine-containing boronic acid on to a CO-RM, introducing drug-like functionality. An LED system was used to facilitate controlled CO-release. Irradiation using an LED (400 nm or 365 nm) gives rise to faster CO-release, with lower overall input power than traditional use of a TLC lamp (365 nm), as measured by an assay based on the conversion of deoxymyoglobin to carbonmonoxymyoglobin.

    Full details in the University publications repository