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Publication - Dr Natalie Pridmore

    Manganese(I)-Catalyzed C−H Activation

    The Key Role of a 7-Membered Manganacycle in H-Transfer and Reductive Elimination

    Citation

    Yahaya, NP, Appleby, KM, Teh, M, Wagner, C, Troschke, E, Bray, JTW, Duckett, SB, Hammarback, LA, Ward, JS, Milani, J, Pridmore, NE, Whitwood, AC, Lynam, JM & Fairlamb, IJS, 2016, ‘Manganese(I)-Catalyzed C−H Activation: The Key Role of a 7-Membered Manganacycle in H-Transfer and Reductive Elimination’. Angewandte Chemie - International Edition, vol 55., pp. 12455-12459

    Abstract

    Manganese-catalyzed C−H bond activation chemistry is emerging as a powerful and complementary method for molecular functionalization. A highly reactive seven-membered MnIintermediate is detected and characterized that is effective for H-transfer or reductive elimination to deliver alkenylated or pyridinium products, respectively. The two pathways are determined at MnIby judicious choice of an electron-deficient 2-pyrone substrate containing a 2-pyridyl directing group, which undergoes regioselective C−H bond activation, serving as a valuable system for probing the mechanistic features of Mn C−H bond activation chemistry.

    Full details in the University publications repository