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Publication - Dr Natalie Pridmore

    Addition of a Cyclophosphine to Nitriles: An Inorganic Click Reaction Featuring Protio, Organo, and Main-Group Catalysis

    An Inorganic Click Reaction Featuring Protio, Organo, and Main-Group Catalysis

    Citation

    Chitnis, S, Sparkes, H, Annibale, V, Pridmore, N, Oliver, A & Manners, I, 2017, ‘Addition of a Cyclophosphine to Nitriles: An Inorganic Click Reaction Featuring Protio, Organo, and Main-Group Catalysis: An Inorganic Click Reaction Featuring Protio, Organo, and Main-Group Catalysis’. Angewandte Chemie - International Edition, vol 56., pp. 9536

    Abstract

    We report the addition of a cyclotriphosphine to a broad range of nitriles giving access to the first examples of free 1-aza-2,3,4-triphospholenes in a rapid, ambient temperature, one-pot, high-yield protocol. The reaction produces electron-rich heterocycles (four lone pairs) and features homoatomic σ-bond heterolysis, thereby combining the key features of the 1,3-dipolar cycloaddition chemistry of azides and cyclopropanes. We also report the first catalytic addition of P-P bonds to the C≡N triple bond. The coordination chemistry of the new heterocycles is explored.

    Full details in the University publications repository