Research Summary

Our group interests lie in the field of organic chemistry, focusing especially on stereoselective synthesis, mechanistic studies and total synthesis of natural and non-natural products. The aim of our research is to design and develop new synthetic tools, allowing ultimately for the efficient and rapid synthesis of complex targets and biologically relevant compounds.

Please consult our publications page for more details.

Main Specific Research Interests:

Homologation of boronic esters and boranes using chiral lithiated carbamates

Reaction scheme showing products formed in more than 95:5 er

  1. M. Althaus, A. Mahmood, J. Ramón Suárez, S.P. Thomas, V.K. Aggarwal, J. Am. Chem. Soc., 2010, 132, 4045-4028.
  2. G. Dutheuil, M.P. Webster, P.A. Worthington, V.K. Aggarwal, Angew. Chem. Int. Ed., 2009, 48, 6317-6319.
  3. F. Schmidt, F. Keller, E. Vedrenne, V.K. Aggarwal, Angew. Chem. Int. Ed., 2009, 48, 1149-1152.
  4. J. L. Stymiest, V. Bagutski, R.M. French, V.K. Aggarwal, Nature, 2008, 456, 778-782.
  5. J. L. Stymiest, G. Dutheuil, A. Mahmood, V.K. Aggarwal, Angew. Chem. Int. Ed., 2007, 46, 7491-7494.

Epoxidation and aziridination using new chiral sulfur ylides

Reaction scheme showing products formed in more than 95% ee

  1. O. Illa, M. Arshad, A. Ros, E.M. McGarrigle, V.K. Aggarwal, J. Am. Chem. Soc., 2010, 132, 1828-1830.
  2. M. Hansch, O. Illa, E.M. McGarrigle, V.K. Aggarwal, Chem. Asian. J., 2008, 3, 1657-1663.

Annulation Reactions

Annulation reaction scheme

  1. M. Yar, E.M. McGarrigle, V.K. Aggarwal, Org. Lett., 2009, 11, 257-260.
  2. M. Yar, E.M. McGarrigle, V.K. Aggarwal, Angew.Chem. Int. Ed., 2008, 47, 3784-3786.

Transition metals catalyzed processes

Scheme showing transition metal catalysed processes

  1. F. Fontana, G.C. Tron, B. Nekane, S. Ferrini, S.P. Thomas, V.K. Aggarwal, Chem. Commun., 2010, 46, 267-269.
  2. A. Ros, V.K. Aggarwal, Angew. Chem. Int. Ed., 2009, 48,6289-6292.

Total synthesis (current targets)

Scheme showing current synthetic targets