Professor Hans Reul

Research summary

My research group investigates how the organism responds and adapts to stressful events.

Major research interests are:

1. The signalling, epigenetic and genomic mechanisms in the brain underlying stress-related learning and memory processes.

2. The regulation of the hypothalamic-pituitary-adrenal (HPA) axis under baseline and stress conditions.

3. The physiological and neurobiological mechanisms underlying the beneficial effects of voluntary exercise on stress coping, HPA axis regulation, and anxiety-related and cognitive behaviour.

Expertise

My research group investigates how the organism responds and adapts to stressful events. The emphasis is on how we learn and form memories of emotionally stressful events in our lives so we ...

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Recent publications

• Mifsud, KR & Reul, JMHM, 2016, ‘Acute stress enhances heterodimerization and binding of corticosteroid receptors at glucocorticoid target genes in the hippocampus’. Proceedings of the National Academy of Sciences of the United States of America.
• Mifsud, KR, Saunderson, EA, Spiers, H, Carter, SD, Trollope, AF, Mill, J & Reul, JMHM, 2016, ‘Rapid down‐regulation of glucocorticoid receptor gene expression in the dentate gyrus after acute stress in vivo: Role of DNA Methylation and microRNA Activity’. Neuroendocrinology.

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View complete publications list in the University of Bristol publications system