Professor Hans Reul

Research summary

My research group investigates how the organism responds and adapts to stressful events.

Major research interests are:

1. The signalling, epigenetic and genomic mechanisms in the brain underlying stress-related learning and memory processes.

2. The regulation of the hypothalamic-pituitary-adrenal (HPA) axis under baseline and stress conditions.

3. The physiological and neurobiological mechanisms underlying the beneficial effects of voluntary exercise on stress coping, HPA axis regulation, and anxiety-related and cognitive behaviour.

Expertise

My research group investigates how the organism responds and adapts to stressful events. The emphasis is on how we learn and form memories of emotionally stressful events in our lives so we ...

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Selected publications

• Gutierrez-Mecinas, M, Trollope, A, Collins, A, Morfett, H, Hesketh, S, Kersante, F & Reul, J 2011, ‘Long-lasting behavioral responses to stress involve a direct interaction of glucocorticoid receptors with ERK1/2-MSK1-Elk-1 signaling’. Proceedings of the National Academy of Sciences of the United States of America, vol 108., pp. 13806 - 13811
• Mifsud, K, Gutierrez-Mecinas, M, Trollope, A, Collins, A, Saunderson, E & Reul, J 2011, ‘Epigenetic mechanisms in stress and adaptation’. Brain, Behavior, and Immunity, vol 25(7)., pp. 1305 - 1315

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Recent publications

• Kersanté, F, Rowley, SCS, Pavlov, I, Gutièrrez-Mecinas, M, Semyanov, A, Reul, JMHM, Walker, MC & Linthorst, ACE 2013, ‘A functional role for both GABA transporter-1 and GABA transporter-3 in the modulation of extracellular GABA and GABAergic tonic conductances in the rat hippocampus’. The Journal of Physiology, vol 591., pp. 2429-2441
• Qian, X, Droste, SK, Lightman, SL, Reul, JMHM & Linthorst, ACE 2012, ‘Circadian and Ultradian Rhythms of Free Glucocorticoid Hormone Are Highly Synchronized between the Blood, the Subcutaneous Tissue, and the Brain’. Endocrinology, vol 153., pp. 4346-4353

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View complete publications list in the University of Bristol publications system