Professor Seth Love
Over the past ten years much of Professor Love's research has focused on the pathogenesis of nerve cell damage and death in neurological disease - Alzheimer's disease in particular.
A hallmark of Alzheimer's disease is the accumulation within the brain of plaques – large clumps of a protein known as Abeta (Aβ). There is now a great deal of evidence that the accumulation of Aβ and the secondary damage this causes to brain tissue is central to the development of Alzheimer's disease. Recent and current research of the Dementia Research Group has concerned the metabolism and clearance of Aβ, the causes and complications of accumulation of Aβ in the tissue and walls of blood vessels within the brain, abnormalities of the cerebral extracellular matrix (the gel-like substance that surrounds and supports the brain cells) in Alzheimer's disease, and the reasons why patients with Alzheimer's disease lose the specialised junctions (synapses) between their nerve cells.
Research
- Cerebral amyloid angiopathy (CAA)
- Metabolism and clearance of Aβ
- Extracellular matrix in Alzheimer's disease
- Synaptic density
- Fatty acids in Alzheimer's disease
- Tangle-mediated interference with Smads
Publications
See Dementia Research Group Publications