Modeling data with structural and temporal correlation using lower level and higher level multilevel models

Authors
James, G., Zhou, Y., and Miller, S.
Year
2011
Journal
Pharmaceutical Statistics, 10(5) , 395 - 406
DOI
10.1002/pst.479
Abstract

Novel imaging techniques are playing an increasingly important role in drug development, providing insight into the mechanism of action of new chemical entities. The data sets obtained by these methods can be large with complex inter-relationships, but the most appropriate statistical analysis for handling this data is often uncertain – precisely because of the exploratory nature of the way the data are collected. We present an example from a clinical trial using magnetic resonance imaging to assess changes in atherosclerotic plaques following treatment with a tool compound with established clinical benefit. We compared two specific approaches to handle the correlations due to physical location and repeated measurements: two-level and four-level multilevel models. The two methods identified similar structural variables, but higher level multilevel models had the advantage of explaining a greater proportion of variation, and the modeling assumptions appeared to be better satisfied

Number of levels
4
Model data structure
Response types
Multivariate response model?
No
Longitudinal data?
Yes
Substantive discipline
Paper submitted by
Gareth James, Primary Care & Population Health, University College London, g.james@ucl.ac.uk