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Publication - Dr Cian O'Donnell

    Beyond excitation/inhibition imbalance in multidimensional models of neural circuit changes in brain disorders

    Citation

    O'Donnell, C, Gonçalves, JT, Portera-Cailliau, C & Sejnowski, TJ, 2017, ‘Beyond excitation/inhibition imbalance in multidimensional models of neural circuit changes in brain disorders’. eLife, vol 6.

    Abstract

    A leading theory holds that neurodevelopmental brain disorders arise from imbalances in excitatory and inhibitory (E/I) brain circuitry. However, it is unclear whether this one-dimensional model is rich enough to capture the multiple neural circuit alterations underlying brain disorders. Here, we combined computational simulations with analysis of in vivo two-photon Ca2+ imaging data from somatosensory cortex of Fmr1 knock-out (KO) mice, a model of Fragile-X Syndrome, to test the E/I imbalance theory. We found that: (1) The E/I imbalance model cannot account for joint alterations in the observed neural firing rates and correlations; (2) Neural circuit function is vastly more sensitive to changes in some cellular components over others; (3) The direction of circuit alterations in Fmr1 KO mice changes across development. These findings suggest that the basic E/I imbalance model should be updated to higher dimensional models that can better capture the multidimensional computational functions of neural circuits.

    Full details in the University publications repository