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Publication - Dr Lucia Marucci

    Modelling dynamics and function of bone marrow cells in mouse liver regeneration

    Citation

    Pedone, E, Olteanu, A, Marucci, L, Munoz-Martin, MI, Youssef, S, Bruin, A & Cosma, M, 2017, ‘Modelling dynamics and function of bone marrow cells in mouse liver regeneration’. Cell Reports, vol 18., pp. 107-121

    Abstract

    In rodents and humans the liver can restore its mass after hepatectomy efficiently. This is largely attributed to the proliferation and cell cycle re-entry of hepatocytes. On the other hand, bone marrow cells (BMCs) migrate into the liver after resection. Here we find that a block of BMC recruitment into the liver severely impairs its regeneration after the surgery. Mobilized hematopoietic stem and progenitor cells (HSPCs) in the resected liver can fuse with hepatocytes and the hybrids proliferate earlier than the hepatocytes. Genetic ablation of the hybrids severely impairs hepatocyte proliferation and liver mass regeneration. Mathematical modelling reveals a key role of BM-derived hybrids to drive proliferation in the regeneration process, and predicts regeneration efficiency in experimentally nontestable conditions. In conclusion, BM-derived hybrids are essential to trigger efficient liver regeneration after hepatectomy.

    Full details in the University publications repository