Microtubules (green) and actin (red) are two components of the intracellular architectural network, the cytoskeleton that structure cells. This is a butterfly-shape cell displaying various transport vesicles (red & green) in an exoskeleton-like manner.
This is an image of a HeLa cell stained for actin (grey) and the cell nucleus (red). While imaging I stumbled across this cell with an unusual heart shaped nucleus. HeLa cells are the oldest and most commonly used immortal cell line; this immortality is reflected in the title "My Heart Will Go On".
This microscopic fluorescent image of the fruit fly's circulatory system shows how the tubular heart (green) is suspended within the body by fan-like muscles radiating outwards. Special excretory organs (red) that lie along the heart capture toxins from the body fluids as they circulate. The genetic material is labelled in blue.
The type III secretion system (T3SS) is a molecular syringe that many pathogenic bacteria use to cause disease. Reconstructed in three dimensions using electron microscopy.
Picture generated by Scanning Electron Microscopy (SEM) of the zebrafish eye epithelium suffering secretion defects from inside to outside of the cell. Large proteins, such as collagen, produced inside the cell are not able to move out and is stocked up under the cell membrane. This forms a tower within the characteristic maze pattern of the zebrafish skin, which streamlines the fish.
DNA gels are a routine technique used in biochemistry to separate DNA fragments by their size. We took the idea of visualizing DNA on a gel and etched the familiar shape of the DNA double helix into the surface. We 'loaded' the gel with a DNA and fluorescent ethidium bromide mix to produce the DNA helix made of DNA!
This crepidula fornicata (sea snail) embryo is undergoing spiral cleavage from 4 to 8 cells. The DNA is shown in blue and the mitotic spindle in yellow.
Two 400 µM thick slices of live brain tissue in an electrophysiology recording chamber. This set-up enables us to record the electrical activity of neurons, in this case from the hippocampus, a structure thought to be involved in learning and memory.
An artistic representation of a hot air balloon (transport vesicle & Golgi apparatus).
The rod and cone photoreceptors are not the only cells in the retina required for visual processing; here a section of retina is stained to highlight amacrine, bipolar and ganglion cells which also play important roles.
A stellate cell from the mouse somatosensory cortex, which receives information about whisker movement, has been fluorescently labeled. You can see the pipette tip patched on to the cell body with all the cells projections, including the tiny spines, clearly visible.
Diatoms are ubiquitous algae that sheath themselves in a silica shell. This 'glass house' can be isolated by digesting diatoms with hydrogen peroxide. This electron micrograph shows individual diatom shells trapped within the digested organic matrix. One diatom is in the centre, how many others can you spot?