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Dr Susan Nicholls

Photo of Dr Susan Nicholls

Dr Susan Nicholls

School of Medical Sciences, University Walk, Bristol
BS8 1TD
(See a map)

s.m.nicholls@bristol.ac.uk

Fax Number (0117) 928 9505
Telephone Number (0117) 331 9060

Organisations

School of Clinical Sciences

Immunology of corneal graft rejection

Biography

see http://www.bristol.ac.uk/clinicalsciencesouth/ophthalmology/research/grafts/interests.html

Diseases related to this field of research

Corneal graft rejection

Processes and functions relevant to this work

Inflammation, immunological rejection, graft failure

Techniques in routine use

Surgery, cell culture, immunohistology, flow cytometry

Collaborations

Prof. Andrew Dick, Prof. Mick Bailey

Expertise

My expertise is in the immunology of graft rejection, with particular reference to corneal transplantation. Past research has involved the study of tissue matching to improve graft survival and recurrence of ocular herpes simplex virus disease after corneal transplantation. My current research focus is on the development of improved models of corneal graft rejection, both for the study of underlying immunological processes and for the development of potential therapeutic agents.

Expertise key words

  • transplant immunology
  • corneal graft rejection



    • Latest publications

    1. Nicholls, SM, Mitchard, LK, Laycock, GM, Harley, R, Murrell, JC, Dick, AD & Bailey, M 2012, ‘A model of corneal graft rejection in semi-inbred NIH miniature swine: significant T cell infiltration of clinically accepted allografts’. Investigative Ophthalmology and Visual Science, vol 53., pp. 3183-3192
    2. Nicholls, S & Dick, A 2008, ‘Lack of IFN-gamma synthesis in aqueous humor during corneal graft rejection correlates with suppressed nitric oxide production by macrophages’. Invest.Ophthalmol.Vis.Sci, vol 49., pp. 4923 - 4930
    3. Nicholls, S, Banerjee, S, Figueiredo, F, Crome, S, Mistry, S, Easty, D & Dick, A 2006, ‘Differences in leukocyte phenotype and interferon-gamma expression in stroma and endothelium during corneal graft rejection’. Experimental Eye Research, vol 83 (2)., pp. 339 - 347
    4. Banerjee, S, Dick, A & Nicholls, S 2004, ‘Factors affecting rejection of second corneal transplants in rats’. Transplantation, vol 77 (4)., pp. 492 - 496
    5. Banerjee, S, Figueiredo, F, Easty, D, Dick, A & Nicholls, S 2003, ‘Development of organised conjunctival leucocyte aggregates after corneal transplantation in rats’. British Journal of Ophthalmology, vol 87 (12)., pp. 1515 - 1522
    6. Figueiredo, F, Nicholls, S & Easty, D 2002, ‘Corneal epithelial rejection in the rat’. Investigative Ophthalmology & Visual Science, vol 43 (3)., pp. 729 - 736
    7. Nicholls, S & Williams, N 2001, ‘MHC matching and mechanisms of alloactivation in corneal transplantation’. Transplantation, vol 72 (9)., pp. 1491 - 1497
    8. Nicholls, S, Diamond, J, Easty, D & Bradley, B 2001, ‘Corneal Transplantation’. in: ThiruS WaldmannH (eds) Pathology and Immunology of Transplantation and Rejection. Blackwell Science, Oxford, UK, pp. 379 - 419
    9. Figueiredo, F, Pendergrast, D, Zhang, L, Easty, D & Nicholls, S 1998, ‘An improved method for examining the corneal endothelium during graft rejection in the rat’. Experimental Eye Research, vol 67., pp. 625 - 630
    10. Lau, C, Nicholls, S & Easty, D 1998, ‘A murine model for interlamellar corneal transplantation’. British Journal of Ophthalmology, vol 82., pp. 294 - 299

    Full publications list in the University of Bristol publications system

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