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Publication - Professor Matthew Avison

    CreC Sensor Kinase Activation Enhances Growth of Escherichia coli in the Presence of Cephalosporins and Carbapenems

    Citation

    Takebayashi, Y, Taylor, ES, Whitwam, S & Avison, MB, 2019, ‘CreC Sensor Kinase Activation Enhances Growth of Escherichia coli in the Presence of Cephalosporins and Carbapenems’. Antimicrobial Agents and Chemotherapy, vol 63.

    Abstract

    Mutants with enhanced growth in the presence of an antibiotic are more difficult to identify than mutants where the antibiotic's minimum inhibitory concentration increases, because they are not amenable to lethal selection in vitro. We report that activatory mutations in the CreC signal sensor enhance growth of Escherichia coli in the presence of cefoxitin, cefotaxime and meropenem without increasing their minimum inhibitory concentrations. Enhanced growth is dependent on over-production of the inner-membrane cre-regulon protein CreD.

    Full details in the University publications repository