How T cell antigen receptor signalling begins
Professor Oreste Acuto (Sir William Dunn School of Pathology, University of Oxford)
E42, Biomedical Sciences Building
School of Cellular and Molecular Medicine seminar.
Prof Acuto's lab is interested in understanding how T cells, central actors of adaptive immune responses, become activated when they encounter foreign substances. Dissecting the molecular underpinning of this process may lead to the discovery new and more effective ways to diagnose, prevent and heal immune dysfunction that leads to autoimmunity or susceptibility to infection.
Towards this goal, they study the nature of signals received by T cells during activation and how these signals are chemically decoded to drive complex decisions. Signalling then leads to immediate or sustained cell responses and determines cell fate. They employ state-of-the-art quantitative mass spectrometry-based proteomics and integrate this approach with in vitro and in vivo genetic and pharmacological manipulation of cells. They integrate this knowledge using computational modeling of signaling circuits and molecular structures, to understand the complex signals involved in T cell regulation.
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