I am interested in elucidating the function of small membrane proteins (ion channels and exchangers) responsible for generating electrical activity of cells in the heart. Defects in ion channel function lead to cardiac rhythm abnormalities (arrhythmias)
I have a long-standing interest in how drugs alter the electrophysiological behaviour of the heart through modifying ion channel function. Drug actions can be beneficial (antiarrhythmic) or dangerous (proarrhythmic). I have general expertise in cardiac ion channel pharmacology and antiarrhythmic drug action, and a particular interest in the hERG potassium channel, which plays an important role in drug-induced arrhythmias and in the congenital 'Short QT syndrome'.
Another area of long-standing interest is the basis of the activity of a key part of the heart's electrical conducting system called the atrioventricular (AV) node. This co-ordinates the normal sequence of beating of the heart's upper and lower chambers (the atria and ventricles).